海关代码：

3404900000

危险类别码：

R36/38

安全说明：

S24/25

危险标志：

Xi

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TQ4025000

CHEMICAL NAME :

Polyethylene glycol #1000

CAS REGISTRY NUMBER :

25322-68-3

LAST UPDATED :

199710

DATA ITEMS CITED :

15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1413,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

32 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640) Volume(issue)/page/year: MSD-937

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

15570 mg/kg

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 3,451,1953

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,293,1951

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

3 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,293,1951

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

>20 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640) Volume(issue)/page/year: MSD-937

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

22500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 39,349,1950 ** TUMORIGENIC DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravaginal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

416 mg/kg/Y-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - other reproductive system tumors

REFERENCE :

BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 15,252,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0788 No. of Facilities: 60 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 1675 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80189 No. of Facilities: 34023 (estimated) No. of Industries: 237 No. of Occupations: 159 No. of Employees: 487377 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7669 No. of Facilities: 37662 (estimated) No. of Industries: 225 No. of Occupations: 183 No. of Employees: 1335913 (estimated) No. of Female Employees: 861947 (estimated)

毒理学数据：

1、急性毒性：大鼠静脉LDL：22 gm/kg；

生态数据：

对水是稍微危害的，若无政府许可，勿将材料排入周围环境。对皮肤、眼睛刺激性很小，口服也很难被胃肠道吸收，毒性很低。将5%（质量）聚氧化乙烯的水溶液注入兔子的眼睛只引起轻微的灼烧。

分子结构数据

1、   摩尔折射率：102.12

2、   摩尔体积（cm³/mol）：300.5

3、   等张比容（90.2K）：826.3

4、   表面张力（dyne/cm）：57.1

5、   极化率（10^-24cm³）：40.48

计算化学数据

1、   疏水参数计算参考值（XlogP）：-1.4

2、   氢键供体数量：2

3、   氢键受体数量：2

4、   可旋转化学键数量：1

5、   拓扑分子极性表面积（TPSA）：40.5

6、   重原子数：4

7、   表面电荷：0

8、   复杂度：6

9、   同位素原子数量：0

10、 确定原子立构中心数量：0

11、 不确定原子立构中心数量：0

12、  确定化学键立构中心数量：0

13、  不确定化学键立构中心数量：0

14、  共价键单元数量：1

• 
  聚乙二醇红外图谱(IR1)
• 
  聚乙二醇红外图谱(IR2)