异稻瘟净,26087-47-8，生产厂家，价格-洛克化工网移动版

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制备方法及用途

物化性质

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MSDS

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异稻瘟净

中文名称：: 异稻瘟净

中文别名：: 异稻瘟净;
O,O-二乙基-S-苄基硫代磷酸酯;
O,O-二异丙基-S-苄基硫赶磷酸酯;
O,O-二异丙基-S-苄基硫化磷酸酯;
稻瘟净;
异丙稻瘟净;
0-0-二乙基-s-苄基硫代磷酸酯

英文名称：: Phosphorothioic acid,O,O-bis(1-methylethyl) S-(phenylmethyl) ester

英文别名：: iprobenfos;
Iprofenfos;
Iprobenfos solution;
O,O-bis(1-methylethyl) S-(phenylmethyl) phosphorothioate;
Iprobenfos;
IBP;
Kitazin L;
Kitazin P;
Ricid P;
O,O-Diisopropyl-S-benzylthiophosphate;
iprobenphos;
di(propan-2-yloxy)phosphorylsulfanylmethylbenzene;
S-benzyl O,O-diisopropyl thiophosphate;
O,O-diisopropyl S-benzyl phosphorothioate;
S-benzyl O,O-di(propan-2-yl) phosphorothioate;
Ricid II;
S-BENZYL O,O-DIISOPROPYL PHOSPHOROTHIOATE;
S-benzyl O,O-diisopropyl phosphorothioate;
S-benzyl diisopropyl phosphorothioate

CAS No.：: 26087-47-8

分子式：: C₁₃H₂₁O₃PS

分子量：: 288.34

精确分子量：: 288.09500

PSA：: 70.64000

MDL：: MFCD00191226

EINECS：: 200-659-6

BRN：: 1974687

InChI：: InChI=1/C13H21O3PS/c1-11(2)15-17(14,16-12(3)4)18-10-13-8-6-5-7-9-13/h5-9,11-12H,10H2,1-4H33

危险品标志：: Xn;N,N,Xn,T,F:

风险术语：: 22-51/53-39/23/24/25-23/24/25-11;

安全术语：: 61-45-36/37;

分子结构式：

SDS：: 查看

异稻瘟净制备方法及用途

制备方法

由异丙醇与三氯化磷反应制取中间体异丙基亚磷酸酯,再将其与氨、氯化苄和硫磺反应制得该品。1.异丙基亚磷酸酯的制备异丙醇以每小时215kg、三氯化磷以每小时50kg(摩尔比为3:1)的速度连续进料,混合后猛烈反应,产生的氯化氢气体通过真空泵从混料锅迅速排除,生成的粗酯进入降膜式甩盘脱酸器。加热,进一步脱酸,以120-130℃的温度离开脱酸器。冷却至40℃以下,得含量为92%-95%的中间体,收率95%-98%。混料锅抽出的气体尚含异氯丙烷,当氯化氢吸收后,常压冷冻可作为副产物回收。2.异稻瘟净的制取O,O-二异丙基硫代磷酸铵及原药合成在同一反应锅内一步合成。将异丙基亚磷酸酯、氯化苄、硫磺(摩尔比为1:1.05:1.02)加入甲苯中,缓缓通入氨,控制温度85-90℃,通氨后继续保温搅拌2h,使反应完全。加水洗去杂质和氯化铵,所得粗品进行连续蒸馏脱除水分和溶剂甲苯,即得含量85%-90%的异稻温净原油,收率约90%。

合成制备方法

由异丙醇与三氯化磷反应制取中间体异丙基亚磷酸酯，再将其与氨、氯化苄和硫磺反应制得该品。1.异丙基亚磷酸酯的制备异丙醇以每小时215kg、三氯化磷以每小时50kg（摩尔比为3：1）的速度连续进料，混合后猛烈反应，产生的氯化氢气体通过真空泵从混料锅迅速排除，生成的粗酯进入降膜式甩盘脱酸器。加热，进一步脱酸，以120-130℃的温度离开脱酸器。冷却至40℃以下，得含量为92%-95%的中间体，收率95%-98%。混料锅抽出的气体尚含异氯丙烷，当氯化氢吸收后，常压冷冻可作为副产物回收。2.异稻瘟净的制取O，O-二异丙基硫代磷酸铵及原药合成在同一反应锅内一步合成。将异丙基亚磷酸酯、氯化苄、硫磺（摩尔比为1：1.05：1.02）加入甲苯中，缓缓通入氨，控制温度85-90℃，通氨后继续保温搅拌2h，使反应完全。加水洗去杂质和氯化铵，所得粗品进行连续蒸馏脱除水分和溶剂甲苯，即得含量85%-90%的异稻温净原油，收率约90%。

用途简介

1.该品为高效、低毒有机磷杀菌剂。主要用于防治稻瘟病。38-39%乳剂,用量为每亩150g,稀释300-600倍使用,防治效果为85%左右。其次,用于防治水稻小粒菌核病、纹枯病,对枯穗病也有一定效果。并能防治黑尾叶蝉、飞虱,与其他杀虫剂混用时,可提高其药效。稻瘟净与马拉硫磷合用有增毒作用 2.有机磷杀菌剂。对半知菌类、担子菌纲和子囊菌纲等各种病原菌均有很强的杀菌活性。对苗立枯病菌、菌核病菌等有良好的杀灭作用。施药方法有毒土、喷雾、拌种、浸渍、土壤撒施等。如茎叶喷雾,每公顷用药量0.5～1kg;种子处理,每50kg棉籽用药量200～300g。 3.用于防治稻瘟病。

用途

1.该品为高效、低毒有机磷杀菌剂。主要用于防治稻瘟病。38-39%乳剂，用量为每亩150g，稀释300-600倍使用，防治效果为85%左右。其次，用于防治水稻小粒菌核病、纹枯病，对枯穗病也有一定效果。并能防治黑尾叶蝉、飞虱，与其他杀虫剂混用时，可提高其药效。稻瘟净与马拉硫磷合用有增毒作用

2.有机磷杀菌剂。对半知菌类、担子菌纲和子囊菌纲等各种病原菌均有很强的杀菌活性。对苗立枯病菌、菌核病菌等有良好的杀灭作用。施药方法有毒土、喷雾、拌种、浸渍、土壤撒施等。如茎叶喷雾，每公顷用药量0.5～1kg；种子处理，每50kg棉籽用药量200～300g。

3.用于防治稻瘟病。^[16]

异稻瘟净毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TE6550000

CHEMICAL NAME :: Phosphorothioic acid, S-benzyl O,O-diisopropyl ester

CAS REGISTRY NUMBER :: 26087-47-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C13-H21-O3-P-S

MOLECULAR WEIGHT :: 288.37

WISWESSER LINE NOTATION :: 1Y1&OPO&S1R&OY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 550 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Behavioral - coma

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(11),75,1985

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2836 mg/m3

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(9),77,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3708 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(9),77,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 29,51,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 525 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 29,51,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 435 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Behavioral - coma

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(11),75,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,500,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 335 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 29,51,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1590 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 29,51,1982

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 2,346,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Behavioral - coma

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(11),75,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 508 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 29,51,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1820 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(11),75,1985

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29200 mg/m3/4H/61D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(11),77,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 35 mg/kg/7D-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 2,294,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 252 mg/kg/28D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 2,346,1977 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1050 ug/kg

SEX/DURATION :: female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(8),16,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 350 ug/kg

SEX/DURATION :: lactating female 14 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(8),16,1993 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 53,99,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.3 mg/m3 JAN 1993

毒理学数据：

1.急性毒性^[8]

LD50：366mg/kg（大鼠经口）

LC50：2836mg/m³（大鼠吸入）

2.刺激性 暂无资料

生态数据：

1.生态毒性^[9] LC50：5.1mg/L（鲤鱼）

2.生物降解性 暂无资料

3.非生物降解性 暂无资料