地塞米松磷酸酯
- 中文名称：
- 地塞米松磷酸酯
- 中文别名：
- 地塞米松磷酸酯;
地塞米松磷酸钠
- 英文名称：
- Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11b,16a)-
- 英文别名：
- dexamethasone phosphate;
Hexadrol phosphate;
dexamethasone-21-phosphate;
Dexamethasone 21-orthophosphate;
Betnelan phosphate;
Dexamethasone-21-dihydrogen-phosphate;
Wymesone;
Neodecadron;
Oradexon phosphate;
Dexamethasone phosphate;
[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] dihydrogen phosphate
- CAS No.：
- 312-93-6
- 分 子 式：
-
C22H30FO8P
- 分 子 量：
- 472.49
- 精确分子量：
- 472.16600
- PSA：
- 151.17000
- EINECS：
- 206-232-0
- InChI：
- The Key: VQODGRNSFPNSQE-CXSFZGCWSA-N3
- 风险术语：
- 62
- 安全术语：
- An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of F− and POx.
- 分子结构式：
-
- SDS：
- 查看
地塞米松磷酸酯 物化性质
- 密度：
- 1.45g/cm3
- 沸点：
- 669.6ºC at 760mmHg
- 闪点：
- 358.7ºC
- 折射率：
- 1.594
- 存储条件/存储方法：
- 通风低温干燥
地塞米松磷酸酯 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU4055000
- CHEMICAL NAME :
- Pregna-1,4-diene-3,20-dione,
9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-,
21-(dihydrogen phosphate)
- CAS REGISTRY NUMBER :
- 312-93-6
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C22-H30-F-O8-P
- MOLECULAR WEIGHT :
- 472.49
- WISWESSER LINE NOTATION :
- L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1OPQQO FQ G1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 36 mg/kg/90D-I
- TOXIC EFFECTS :
- Endocrine - changes in thymus weight
Immunological Including Allergic - decrease in cellular immune response
Immunological Including Allergic - decrease in humoral immune response
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 600 ug/kg
- SEX/DURATION :
- female 21-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - endocrine system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 200 ug/kg
- SEX/DURATION :
- female 19-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - respiratory system
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 400 ug/kg
- SEX/DURATION :
- female 19-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - hepatobiliary system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 30 mg/kg
- SEX/DURATION :
- female 8-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Fertility - other measures of fertility
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 600 ug/kg
- SEX/DURATION :
- female 17-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - cytological changes (including
somatic cell genetic material)
Reproductive - Specific Developmental Abnormalities - respiratory system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 600 ug/kg
- SEX/DURATION :
- female 17-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 11-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 14-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 22-25 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
MUTATION DATA
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 3 mg/kg
- REFERENCE :
- JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
Volume(issue)/page/year: 62,527,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3850
No. of Facilities: 130 (estimated)
No. of Industries: 3
No. of Occupations: 10
No. of Employees: 5388 (estimated)
No. of Female Employees: 2968 (estimated)
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上海吉至生化科技有限公司
地塞米松磷酸酯
- 联系人：江珊
- 电 话：021-57520831
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- Cas号：312-93-6
- 包装：1gea,200mgea
- 纯度：98%
- 价格：2,100.0元 - 9,088.0元
陕西萃康医药科技有限公司
地塞米松磷酸钠
- 联系人：王
- 电 话：13119157289
- 手 机：13119157289
- Cas号：312-93-6
- 包装：mg/瓶kg,1000/托kg,100/桶kg,10/袋g,25/桶kg
- 纯度：
- 价格：洽谈
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地塞米松磷酸酯
- 联系人：邵经理
- 电 话：16621771607
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