4-乙酰基-2-仲-丁基-5-羟基-1,2-二氢-3H-吡咯-3-酮
- 中文名称：
- 4-乙酰基-2-仲-丁基-5-羟基-1,2-二氢-3H-吡咯-3-酮
- 中文别名：
- 2H-Pyrrol-2-one,3-acetyl-1,5-dihydro-4-hydroxy-5-[(1S)-1-methylpropyl]-, monosodium salt, (5S)-(9CI)
- 英文名称：
- 2H-Pyrrol-2-one,3-acetyl-1,5-dihydro-4-hydroxy-5-[(1S)-1-methylpropyl]-, monosodium salt, (5S)-(9CI)
- 英文别名：
- 2H-Pyrrol-2-one,3-acetyl-1,5-dihydro-4-hydroxy-5-[(1S)-1-methylpropyl]-, monosodium salt, (5S)-(9CI);
Tenuazonic acid sodium salt;
Sodium(5S)-3-acetyl-5-[(S)-1-methylpropyl]-4-hydroxy-3-pyrroline-2-olate
- CAS No.：
- 1013-59-8
- 分 子 式：
-
C10H15NO3.Na
- 分 子 量：
- 219.24
- 精确分子量：
- 220.09500
- PSA：
- 66.40000
- 安全术语：
- Poison by ingestion and intravenous routes. When heated to decomposition it emits toxic fumes of NOx and Na2O.
- 分子结构式：
-
- SDS：
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4-乙酰基-2-仲-丁基-5-羟基-1,2-二氢-3H-吡咯-3-酮 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UY7525000
- CHEMICAL NAME :
- 3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-,
monosodium salt
- CAS REGISTRY NUMBER :
- 1013-59-8
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C10-H14-N-O3.Na
- MOLECULAR WEIGHT :
- 219.24
- WISWESSER LINE NOTATION :
- T5MV EHJ CV1 DO EY2&1 &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 168 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - other changes
Blood - hemorrhage
- REFERENCE :
- CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For
publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 146 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - other changes
Blood - hemorrhage
- REFERENCE :
- CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For
publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 81 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - other changes
Blood - hemorrhage
- REFERENCE :
- CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For
publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 115 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - other changes
Blood - hemorrhage
- REFERENCE :
- CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For
publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >40 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For
publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 90 mg/kg/9D-I
- TOXIC EFFECTS :
- Blood - hemorrhage
- REFERENCE :
- CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For
publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 70 mg/kg/28D-I
- TOXIC EFFECTS :
- Gastrointestinal - necrotic changes
Blood - hemorrhage
Related to Chronic Data - death
- REFERENCE :
- CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For
publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
