丙嗪; N,N-二甲基-3-(10H-吩噻嗪-10-基)丙-1-胺
- 中文名称:
- 丙嗪; N,N-二甲基-3-(10H-吩噻嗪-10-基)丙-1-胺
- 中文别名:
- 丙嗪;
N,N-二甲基-3-(10H-吩噻嗪-10-基)丙-1-胺
- 英文名称:
- 10H-Phenothiazine-10-propanamine,N,N-dimethyl-
- 英文别名:
- promazine;
Berophen;
N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;
Ampazine;
Promazina;
N,N-dimethyl-10H-phenothiazine-10-propanamine;
Sinophenin;
Liranol;
Protactyl;
Promazin;
Prazine;
Esparin
- CAS No.:
- 58-40-2
- 分 子 式:
-
C17H20N2S
- 分 子 量:
- 284.42
- 精确分子量:
- 284.13500
- PSA:
- 31.78000
- EINECS:
- 200-382-0
- InChI:
- The Key: ZGUGWUXLJSTTMA-UHFFFAOYSA-N3
- 分子结构式:
-
- SDS:
- 查看
丙嗪; N,N-二甲基-3-(10H-吩噻嗪-10-基)丙-1-胺 物化性质
- 密度:
- 1.133g/cm3
- 沸点:
- 412.7ºC at 760mmHg
- 闪点:
- 203.4ºC
丙嗪; N,N-二甲基-3-(10H-吩噻嗪-10-基)丙-1-胺 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SO7000000
- CHEMICAL NAME :
- Phenothiazine, 10-(3-(dimethylamino)propyl)-
- CAS REGISTRY NUMBER :
- 58-40-2
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C17-H20-N2-S
- MOLECULAR WEIGHT :
- 284.45
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B3N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 8,507,1958
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 210 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
1,156,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 192 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 24,1798,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 14500 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - changes in circulation
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 119,311,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 401 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 8,489,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
spasmolytic)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 155,69,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 24,1798,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Behavioral - sleep
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
19,87,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 120,450,1959
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 80 mg/kg
- SEX/DURATION :
- female 1-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
- REFERENCE :
- JNEUAY Journal of Neuropsychiatry. (Chicago, IL) V.1-5, 1959-64. For
publisher information, see BENPBG. Volume(issue)/page/year: 3,295,1962
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 4 mg/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 12,346,1961
*** REVIEWS ***
TOXICOLOGY REVIEW
IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79.
Discontinued. Volume(issue)/page/year: 1,203,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6079
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 628 (estimated)
No. of Female Employees: 314 (estimated)
丙嗪; N,N-二甲基-3-(10H-吩噻嗪-10-基)丙-1-胺 分子结构与计算化学数据
分子结构数据
1、 摩尔折射率:87.85
2、 摩尔体积(cm3/mol):250.9
3、 等张比容(90.2K):649.7
4、 表面张力(dyne/cm):44.9
5、 极化率(10-24cm3):34.82
计算化学数据
1.疏水参数计算参考值(XlogP):无
2.氢键供体数量:0
3.氢键受体数量:3
4.可旋转化学键数量:4
5.互变异构体数量:无
6.拓扑分子极性表面积31.8
7.重原子数量:20
8.表面电荷:0
9.复杂度:285
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
丙嗪; N,N-二甲基-3-(10H-吩噻嗪-10-基)丙-1-胺 上游产品
丙嗪; N,N-二甲基-3-(10H-吩噻嗪-10-基)丙-1-胺 下游产品
推荐供应商
沭阳县丰泰化学品有限公司
丙嗪
- 联系人:刘树德
- 电 话:0527-83966999
- 手 机:013605240389
- Cas号:58-40-2
- 包装:2kg
- 纯度:98%-99%
- 价格:洽谈
广东利玮医药有限公司
丙嗪
- 联系人:陈凡
- 电 话:020-87687760
- 手 机:
- Cas号:58-40-2
- 包装:2kg
- 纯度:98%-99%
- 价格:洽谈