唑螨酯,134098-61-6，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

结构与计算化学

唑螨酯

中文名称：: 唑螨酯

中文别名：: 唑螨酯;
杀螨王;
(E)-alpha-(1,3-二甲基-5-苯氧基吡唑-4-亚甲基氨基氧)对甲苯甲酸叔丁酯;
(E)-Α-(1,3-二甲基-5-苯氧基吡唑-4-基亚甲基氨基氧)对甲苯甲酸叔丁酯

英文名称：: Benzoicacid,4-[[[(E)-[(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]-,1,1-dimethylethyl ester

英文别名：: fenpyroximate;
DANITRON;
tert-butyl (E)-α-(1,3-dimethyl-5-phenoxypyrazol-4-ylmethyleneaminooxy)-p-toluate;
ORTUS;
Trophloabul;
KIRON;
Fenpyroximate;
1,1-dimethylethyl 4-[[[(E)-[(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]benzoate;
tert-butyl 4-[({[(E)-(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylidene]amino}oxy)methyl]benzoate;
uate;
PAMANRIN;
nni850;
DANITORON;
fenproximate

CAS No.：: 134098-61-6

分子式：: C₂₄H₂₇N₃O₄

分子量：: 421.50

精确分子量：: 421.20000

PSA：: 74.94000

危险品标志：: XnN

风险术语：: R20;R50/53;

安全术语：: S22;S60;S61;

分子结构式：

SDS：: 查看

唑螨酯制备方法及用途

制备方法

1、 5-氯-1,3-二甲基-4-吡唑甲醛的制备先用乙酰乙酸乙酯与甲肼作用,生成1,3-二甲基吡唑-5-酮。然后加入到三氯氧磷-二甲基甲酰胺溶液中。于110～115℃反应8h,得5-氯-1,3-二甲基-4-吡唑甲醛。 2、 1,3-二甲基-5-苯氧基-4-吡唑甲醛的制备先将苯酚、甲醇钠的甲醇溶液加热回流,蒸出甲醇,加入DMF和上步反应产物,于100℃反应4h,减压回收DMF后,冷却、加水、用二氯乙烷萃取,得1,3-二甲基-5-苯氧基-4-吡唑甲醛。 3、 1,3-二甲基-5-苯氧基-4-吡唑甲醛肟的制备将上步产物溶于甲醇中,加入盐酸羟胺,在搅拌下加入氢氧化钾溶液,于60℃反应1h,减压蒸去甲醇,水洗干燥后得白色1,3-二甲基-5-苯氧基-4-吡唑甲醛肟。 4、唑螨酯的合成将上步产物与4-溴甲基苯甲酸特丁酯(合成方法参见特开昭63-183564, 63-267754)在丙酮溶剂中,加入适量碳酸钾,回流反应8h得唑螨酯,目的产物为反式异构体。

合成制备方法

1、 5-氯-1，3-二甲基-4-吡唑甲醛的制备先用乙酰乙酸乙酯与甲肼作用，生成1，3-二甲基吡唑-5-酮。然后加入到三氯氧磷-二甲基甲酰胺溶液中。于110～115℃反应8h，得5-氯-1，3-二甲基-4-吡唑甲醛。

2、 1，3-二甲基-5-苯氧基-4-吡唑甲醛的制备先将苯酚、甲醇钠的甲醇溶液加热回流，蒸出甲醇，加入DMF和上步反应产物，于100℃反应4h，减压回收DMF后，冷却、加水、用二氯乙烷萃取，得1，3-二甲基-5-苯氧基-4-吡唑甲醛。

3、 1,3-二甲基-5-苯氧基-4-吡唑甲醛肟的制备将上步产物溶于甲醇中，加入盐酸羟胺，在搅拌下加入氢氧化钾溶液，于60℃反应1h，减压蒸去甲醇，水洗干燥后得白色1，3-二甲基-5-苯氧基-4-吡唑甲醛肟。

4、唑螨酯的合成将上步产物与4-溴甲基苯甲酸特丁酯（合成方法参见特开昭63-183564， 63-267754）在丙酮溶剂中，加入适量碳酸钾，回流反应8h得唑螨酯，目的产物为反式异构体。

用途简介

1.高效、广谱苯氧基吡唑类杀螨剂。对多种害螨有强烈触杀作用,对幼螨活性最高,且持效期长。对其他药剂无交互抗性。防治柑橘红蜘蛛用25～50mg/L药液喷雾;苹果红蜘蛛用16～25mg/L药液喷雾。适用于多种植物上防治红叶螨和全爪叶螨。对小菜蛾、斜纹夜蛾、二化螟、稻飞虱、桃蚜等害虫及稻瘟病、白粉病、霜霉病等病害亦有良好防治作用。

用途

1.高效、广谱苯氧基吡唑类杀螨剂。对多种害螨有强烈触杀作用，对幼螨活性最高，且持效期长。对其他药剂无交互抗性。防治柑橘红蜘蛛用25～50mg/L药液喷雾；苹果红蜘蛛用16～25mg/L药液喷雾。适用于多种植物上防治红叶螨和全爪叶螨。对小菜蛾、斜纹夜蛾、二化螟、稻飞虱、桃蚜等害虫及稻瘟病、白粉病、霜霉病等病害亦有良好防治作用。

唑螨酯毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG9081200

CHEMICAL NAME :: Benzoic acid, 4-(((((1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methyle ne)amino)oxy)methyl)-, 1,1-dimethylethyl ester, (E)-

CAS REGISTRY NUMBER :: 134098-61-6

LAST UPDATED :: 199607

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C24-H27-N3-O4

MOLECULAR WEIGHT :: 421.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 330 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2730 mg/kg/13W-C

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - urine volume decreased Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6552 mg/kg/2Y-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Kidney, Ureter, Bladder - urine volume decreased Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 4550 mg/kg/13W-I

TOXIC EFFECTS :: Cardiac - change in rate Liver - changes in liver weight

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 5460 mg/kg/52W-I

TOXIC EFFECTS :: Cardiac - EKG changes not diagnostic of specified effects Cardiac - change in rate Gastrointestinal - hypermotility, diarrhea

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

毒理学数据：: 原药对大鼠急性经口LD₅₀为245～480mg/kg，急性经皮LD₅₀>2000mg/kg，急性吸入LC₅₀为0.33mg/L(雄）。对兔皮肤和眼睛有轻度刺激作用。90d饲喂试验对大鼠经口无作用剂量为20mg/kg，狗为2mg/kg。2年慢性毒性试验大鼠无作用剂量25mg/kg。动物试验无致畸、致癌、致突变作用。鲤鱼LC₅₀为6.1×10^-9g/L (48h)。