替宁酸
- 中文名称：
- 替宁酸
- 中文别名：
- 替宁酸;
2,3-二氯-4-(2-噻吩甲酰基)苯氧基乙酸;
噻吩利尿酸;
2-(2,3-二氯-4-(噻吩-2-羰基)苯氧基)乙酸
- 英文名称：
- TICRYNAFEN
- 英文别名：
- tienilic acid;
[2,3-dichloro-4-(2-thenoyl)phenoxy]acetic acid;
[2,3-dichloro-4-(thiophene-2-carbonyl)-phenoxy]-acetic acid;
Thienylic acid;
Ticrex;
Diflurex;
Tienilico acido;
Acido tienilico;
2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid;
TienilicAcid;
Acidum tienilicum;
2,3-dichloro-4-(thien-2-ylcarbonyl)-phenoxyacetic acid;
Tienilic acid;
Ticrynafen;
Acide tienilique;
Selacryn;
Ticrynafen Tienylic acid [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]-acetic acid
- CAS No.：
- 40180-04-9
- 分 子 式：
-
C13H8Cl2O4S
- 分 子 量：
- 331.17
- 精确分子量：
- 329.95200
- PSA：
- 91.84000
- EINECS：
- 254-826-3
- InChI：
- InChI=1/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17)3
- SDS：
- 查看
替宁酸 物化性质
- 密度：
- 1.532g/cm3
- 熔点：
- 148-149ºC
- 沸点：
- 534.6ºC at 760 mmHg
- 闪点：
- 277.1ºC
- 折射率：
- 1.632
替宁酸 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AG9300000
- CHEMICAL NAME :
- Acetic acid,
(2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)-
- CAS REGISTRY NUMBER :
- 40180-04-9
- BEILSTEIN REFERENCE NO. :
- 1260086
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C13-H8-Cl2-O4-S
- MOLECULAR WEIGHT :
- 331.17
- WISWESSER LINE NOTATION :
- T5SJ BVR BG CG DO1VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 3571 ug/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - urine volume decreased
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 6666 ug/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - urine volume decreased
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1275 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 318 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 225 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3360 mg/kg/28D-I
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
Liver - changes in liver weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6300 mg/kg/14D-I
- TOXIC EFFECTS :
- Liver - other changes
Kidney, Ureter, Bladder - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 157,1,1985
替宁酸 海关数据
中国海关编码：2934999090
- 概述：
- 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途
- 摘要/Summary：
- 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
推荐供应商
上海吉至生化科技有限公司
替宁酸
- 联系人：江珊
- 电 话：021-57520831
- 手 机：15316869680
- Cas号：40180-04-9
- 包装：20mgea
- 纯度：分析对照品,HPLC≥98%
- 价格：378.0元
上海源叶生物科技有限公司
替宁酸
- 联系人：Yuki
- 电 话：021-61845781
- 手 机：13585604150
- Cas号：40180-04-9
- 包装：20mg
- 纯度：HPLC≥98%
- 价格：320.0元
湖北恩星生物科技有限公司
替宁酸
- 联系人：邵经理
- 电 话：16621771607
- 手 机：16621771607
- Cas号：40180-04-9
- 包装：100kg,200kg,300kg,400kg,500kg
- 纯度：
- 价格：64.0元 - 100.0元