二氯甲基醚,542-88-1，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

结构与计算化学

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二氯甲基醚

中文名称：: 二氯甲基醚

中文别名：: 二氯甲基醚;
α,α’-二氯甲醚;
双氯甲醚;
氧代二氯甲烷;
对称二氯二甲醚;
二氯甲醚;
双-(氯甲基)醚;
对称二氯甲醚

英文名称：: BIS(CHLOROMETHYL)ETHER

英文别名：: chloro(chloromethoxy)methane;
dicarbonyl chloride;
di(chloromethyl)ether;
Oxybis(chloromethane);
sym-Dichloromethyl ether;
monochloromethyl ether;
Ether,bis(chloromethyl);
dichlorodimethyl ether;
bis(chloromethyl)-ether;
BCME;
Methane,oxybis[chloro;
Chloromethyl ether

CAS No.：: 542-88-1

分子式：: C2H4Cl2O

分子量：: 114.96

精确分子量：: 113.96400

PSA：: 9.23000

EINECS：: 208-832-8

InChI：: The Key: HRQGCQVOJVTVLU-UHFFFAOYSA-N3

风险术语：: R10; R36/37/38; R40; R26; R24; R22; R45

SDS：: 查看

二氯甲基醚制备方法及用途

制备方法

1.由多聚甲醛经氯化而得。 2.制法: 于装有搅拌器、温度计、滴液漏斗的反应瓶中,加入1.0kg(31.25mol)多聚甲醛(2)、250g浓盐酸,冰水浴冷却至10℃以下,搅拌下慢慢滴加氯磺酸3.9kg,控制滴加速度保持反应温度在10℃左右。加完后室温搅拌反应4h。放置过夜。分出上层溶液,用冰水洗涤两次,再用40%的氢氧化钠溶液及少量碎冰洗涤,固体氢氧化钠干燥。常压分馏,收集100～105℃的馏分,得a,a′-二氯二甲醚①(1)2.3kg,收率65%。注:①该化合物为剧毒品,并有致癌作用,使用时应特别注意安全。

合成制备方法

1.由多聚甲醛经氯化而得。

2.制法：

于装有搅拌器、温度计、滴液漏斗的反应瓶中，加入1.0kg(31.25mol)多聚甲醛（2）、250g浓盐酸，冰水浴冷却至10℃以下，搅拌下慢慢滴加氯磺酸3.9kg，控制滴加速度保持反应温度在10℃左右。加完后室温搅拌反应4h。放置过夜。分出上层溶液，用冰水洗涤两次，再用40%的氢氧化钠溶液及少量碎冰洗涤，固体氢氧化钠干燥。常压分馏，收集100～105℃的馏分，得a，a′-二氯二甲醚^①（1）2.3kg，收率65%。注：①该化合物为剧毒品，并有致癌作用，使用时应特别注意安全。^[23]

用途简介

1.作药物消瘤芥、八氮二丙醚、双解磷的中间体。也是维生素B2的中间体(合成3,4-二甲基苯胺的原料)。 2.用于有机合成;医药工业用于合成抗肿瘤药淄瘤芥、解毒药物双复磷等。 3.工业上用作甲基化剂、试剂和制造离子交换树脂的中间体。

用途

1.作药物消瘤芥、八氮二丙醚、双解磷的中间体。也是维生素B2的中间体（合成3,4-二甲基苯胺的原料）。

2.用于有机合成；医药工业用于合成抗肿瘤药淄瘤芥、解毒药物双复磷等。

3.工业上用作甲基化剂、试剂和制造离子交换树脂的中间体。^[22]

二氯甲基醚毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KN1575000

CHEMICAL NAME :: Ether, bis(chloromethyl)

CAS REGISTRY NUMBER :: 542-88-1

BEILSTEIN REFERENCE NO. :: 1679223

LAST UPDATED :: 199712

DATA ITEMS CITED :: 56

MOLECULAR FORMULA :: C2-H4-Cl2-O

MOLECULAR WEIGHT :: 114.96

WISWESSER LINE NOTATION :: G1O1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 3 ppm

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 100 ppm/3M

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 ppm/7H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - hemorrhage

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/m3/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 280 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 7 ppm/7H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - hemorrhage

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 ppb/6H/4W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 375 mg/kg/43W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 ppb/6H/26W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5520 mg/kg/23W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg/61W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 384 mg/kg/42W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 640 mg/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 ppb/6H/6W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12500 ug/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - hair

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 ppb/6H/26W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 ppm/82D-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - increased incidence of tumors in susceptible strains

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 ppb/6H/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11 gm/kg/44W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Kidney

REFERENCE :: BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 37,873,1978 *** REVIEWS *** ACGIH TLV-Confirmed human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.0047 mg/m3 (0.001 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,231,1974 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,231,1974 IARC Cancer Review:Group 1 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,131,1987 TOXICOLOGY REVIEW ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B: Hygiene, Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart, Fed. Rep. Ger.) V.155-169, 1971-1979. For publisher information, see ZAOMDC. Volume(issue)/page/year: 166,113,1978 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Construc):see CFR 29,1926.1108 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA-cancer suspect agent CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1008,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.001 ppm (0.006 mg/m3);Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.001 ppm (0.0047 mg/m3);Carcinogen JAN 1993 OEL-DENMARK:TWA 0.001 ppm (0.005 mg/m3);Carcinogen JAN 1993 OEL-FINLAND:TWA 0.001 ppm (0.004 mg/m3);STEL 0.003 ppm;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.001 ppm (0.006 mg/m3);Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-INDIA:TWA 0.001 ppm (0.005 mg/m3);Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.001 ppm JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.001 ppm (0.005 mg/m3);Carcinogen JAN 1993 OEL-UNITED KINGDOM:TWA 0.001 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BIS(CHLOROMETHYL) ETHER-air:CA use 29 CFR 1910.1008 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6315 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 14 (estimated) No. of Female Employees: 5 (estimated)

毒理学数据：

1.急性毒性^[10]

LD50：210mg/kg（大鼠经口）

LC50：33mg/m³（小鼠吸入，7h）

2.刺激性 暂无资料

3.致突变性^[11]

微生物致突变：鼠伤寒沙门菌20μg/皿。程序外DNA合成：小鼠皮肤染毒部位360μmol/kg。

4.致癌性^[12] IARC致癌性评论：G1，确认人类致癌物。

生态数据：

1.生态毒性^[13] LC50：0.9~3.4mg/L（96h）（鱼）

2.生物降解性^[14]

好氧生物降解（h）：168~672

厌氧生物降解（h）：672~2688

3.非生物降解性^[15]

空气中光氧化半衰期（h）：0.196~1.96

一级水解半衰期（h）：0.106

二氯甲基醚 MSDS

国标编号:	61086
ＣＡＳ:	542-88-1
中文名称:	二氯(二)甲醚
英文名称:	dichloromethyl ether
别名:	对称二氯(二)甲醚
分子式:	C₂H₄Cl₂O；ClCH₂OCH₂Cl
分子量:	114.96
熔点:	-41.5℃
密度:	相对密度(水=1)1.32
蒸汽压:
溶解性:	可混溶于乙醇、乙醚等多数有机溶剂
稳定性:	稳定
外观与性状:	无色液体，有刺激性气味，易挥发
危险标记:	13(剧毒品)
用途:	工业上用作甲基化剂

2.对环境的影响:
一、健康危害

侵入途径：吸入、食入。
健康危害：本品对眼、皮肤和粘膜有强烈的刺激作用。当浓度为470mg/m3时，1-2分钟接触即可引起致死性肺损害。未稀释本品可致兔皮肤坏死。

二、毒理学资料及环境行为

急性毒性：LD50210mg/kg(小鼠经口)；LC5033mg/m3，7小时(小鼠吸入)
刺激性：家兔经眼：162mg，中度刺激。家兔经皮：810mg(24小时)，重度刺激。
致癌性：本品可引起肺癌。国际癌症研究中心(IARC)已确定为人类致癌物。

危险特性：易燃，遇明火、高热能引起燃烧爆炸。遇水或受热分解放出有毒的腐蚀性气体。
燃烧(分解)产物：一氧化碳、二氧化碳、氯化氢。

3.现场应急监测方法:
　

4.实验室监测方法:
气相色谱法《空气中有害物质的测定方法》(第二版)杭士平主编
水中的测定：用气相气谱法(EPA611法)或色质联用仪测定(EPA625法)

5.环境标准:
美国车间卫生标准 0.0047mg/m3

6.应急处理处置方法:
一、泄漏应急处理

迅速撤离泄漏污染区人员至安全区，并进行隔离，严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿防毒服。不要直接接触泄漏物。尽可能切断泄漏源。防止进入下水道、排洪沟等限制性空间。小量泄漏：用砂土或其它不燃材料吸附或吸收。大量泄漏：构筑围堤或挖坑收容；用泡沫覆盖，降低蒸气灾害。用泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。
废弃物处置方法：建议用焚烧法处置。废料同其他燃料混合后再焚烧，燃烧要充分、防止生成光气。焚烧炉排气中的卤化氢通过酸洗涤器除去。

二、防护措施

呼吸系统防护：可能接触其蒸气时，必须佩戴自吸过滤式防毒面具(全面罩)。紧急事态抢救或撤离时，佩戴空气呼吸器。
眼睛防护：呼吸系统防护中已作防护。
身体防护：穿胶布防毒衣。
手防护：戴防化学品手套。
其它：工作现场禁止吸烟、进食和饮水。工作毕，彻底清洗。单独存放被毒物污染的衣服，洗后备用。保持良好的卫生习惯。

三、急救措施

皮肤接触：立即脱去被污染的衣着，用大量流动清水冲洗，至少15分钟。就医。
眼睛接触：立即提起眼睑，用大量流动清水或生理盐水彻底冲洗至少15分钟。就医。
吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。
食入：饮足量温水，催吐，就医。

灭火方法：消防人员须佩戴防毒面具、穿全身消防服。灭火剂：水、二氧化碳、干粉、砂土。

二氯甲基醚

二氯甲基醚制备方法及用途

制备方法

合成制备方法

用途简介

用途

二氯甲基醚物化性质

二氯甲基醚安全信息

二氯甲基醚毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

二氯甲基醚 MSDS

二氯甲基醚分子结构与计算化学数据

分子结构数据

计算化学数据

二氯甲基醚上游产品

二氯甲基醚下游产品

推荐供应商

二氯甲基醚

二氯甲基醚 制备方法及用途

制备方法

合成制备方法

用途简介

用途

二氯甲基醚 物化性质

二氯甲基醚 安全信息

二氯甲基醚 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

二氯甲基醚 MSDS

二氯甲基醚 分子结构与计算化学数据

分子结构数据

计算化学数据

二氯甲基醚 上游产品

二氯甲基醚 下游产品

推荐供应商

二氯甲基醚制备方法及用途

二氯甲基醚物化性质

二氯甲基醚安全信息

二氯甲基醚毒理性

二氯甲基醚分子结构与计算化学数据

二氯甲基醚上游产品

二氯甲基醚下游产品