利替培南
- 中文名称：
- 利替培南
- 中文别名：
- 利替培南
- 英文名称：
- Ritipenem
- 英文别名：
- Ritipenem;
RITIPENEM ACOXIL
- CAS No.：
- 84845-57-8
- 分 子 式：
-
C10H12N2O6S
- 分 子 量：
- 288.27700
- 精确分子量：
- 288.04200
- PSA：
- 155.46000
- InChI：
- The Key: IKQNRQOUOZJHTR-UWBRJAPDSA-N3
- SDS：
- 查看
利替培南 物化性质
- 密度：
- 1.71g/cm3
- 沸点：
- 659.4ºC at 760 mmHg
- 闪点：
- 352.6ºC
- 折射率：
- 1.691
利替培南 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XI0191750
- CHEMICAL NAME :
- 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic
acid, 3-(((aminocarbonyl)oxy)methyl)-
6-(1-hydroxyethyl)-7-oxo-, (5R-(5alpha,6alpha(R*)))-
- CAS REGISTRY NUMBER :
- 84845-57-8
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C10-H12-N2-O6-S
- MOLECULAR WEIGHT :
- 288.30
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - changes in potassium
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 29,3475,1995
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3500 mg/kg/7D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - changes in chlorine
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 29,3475,1995