海关代码：

29400090

WGK_Germany：

3
德国有关水污染物质的分类清单

危险类别码：

36/37/38

安全说明：

S22-S24/25

RTECS号：

LW5490000

安全标志：

S22:不要吸入粉尘。
S24/25:防止皮肤和眼睛接触。

危险标志：

Xi

CHEMICAL IDENTIFICATION

RTECS NUMBER :

LW5490000

CHEMICAL NAME :

Galactose, D-

CAS REGISTRY NUMBER :

59-23-4

BEILSTEIN REFERENCE NO. :

1724619

LAST UPDATED :

199709

DATA ITEMS CITED :

12

MOLECULAR FORMULA :

C6-H12-O6

MOLECULAR WEIGHT :

180.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

240 gm/kg

SEX/DURATION :

female 11-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :

JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 70,676,1967

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

188 gm/kg

SEX/DURATION :

female 8-10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :

ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd. Saint-Germain, F-25280 Paris Cedex 06, France) V.1- 1939- Volume(issue)/page/year: 20,203,1959

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

440 gm/kg

SEX/DURATION :

female 1-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :

JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 67,438,1965

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

475 gm/kg

SEX/DURATION :

female 3-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - other postnatal measures or effects

REFERENCE :

SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 214,1145,1981

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1000 gm/kg

SEX/DURATION :

female 3-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - germ cell effects (in offspring)

REFERENCE :

SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 214,1145,1981

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1260 gm/kg

SEX/DURATION :

female 1-21 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - abortion Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 31,29A,1985

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

630 gm/kg

SEX/DURATION :

female 1-21 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - eye/ear

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 33,46C,1986

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

16500 mg/kg

SEX/DURATION :

female 8-12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :

TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 7,7,1987

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

840 gm/kg

SEX/DURATION :

female 14 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - other measures of fertility

REFERENCE :

FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 49,522,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81790 No. of Facilities: 97 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 1707 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81790 No. of Facilities: 148 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 2013 (estimated) No. of Female Employees: 1456 (estimated)

毒理学数据：

1、繁殖毒性：雌性大鼠经口TDLo：240mg/kg，11-22天后受孕；雌性大鼠经口TDLo：188mg/kg，8-10天后受孕；雌性大鼠经口TDLo：40mg/kg，1-22天后受孕；雌性大鼠经口TDLo：475mg/kg，3-22天后受孕；雌性大鼠经口TDLo：1000mg/kg，3-22天后受孕；雌性小鼠经口TCLo：1260mg/kg，1-21天后受孕；雌性小鼠经口TCLo：630mg/kg，1-2天后受孕；雌性小鼠经口TCLo：16500mg/kg，8-12天后受孕；

分子结构数据

 

1、   摩尔折射率：37.25

2、   摩尔体积（cm³/mol）：104.0

3、   等张比容（90.2K）：312.7

4、   表面张力（dyne/cm）：81.7

5、   极化率（10^-24cm³）：14.76

 

计算化学数据

1、   计疏水参数计算参考值（XlogP）：-2.6

2、   氢键供体数量：5

3、   氢键受体数量：6

4、   可旋转化学键数量：1

5、   互变异构体数量：

6、   拓扑分子极性表面积（TPSA）：110

7、   重原子数量：12

8、   表面电荷：0

9、   复杂度：151

10、同位素原子数量：0

11、确定原子立构中心数量：4

12、不确定原子立构中心数量：0

13、确定化学键立构中心数量：0

14、不确定化学键立构中心数量：0

15、共价键单元数量：1