二氯溴甲烷,75-27-4，生产厂家，价格-洛克化工网移动版

二氯溴甲烷

中文名称：: 二氯溴甲烷

中文别名：: 一溴二氯甲烷;
二氯溴甲烷;
二氯一溴甲烷;
溴二氯代甲烷

英文名称：: bromodichloromethane

英文别名：: bromodichloromethane;
BROMODICHLOROMETHANE;
bromo(dichloro)methane

CAS No.：: 75-27-4

分子式：: CHBrCl₂

分子量：: 163.83

精确分子量：: 161.86400

PSA：: 0.00000

MDL：: MFCD00000824

EINECS：: 200-856-7

BRN：: 1697005

InChI：: InChI=1/CHBrCl2/c2-1(3)4/h1H3

危险品标志：: Xn

风险术语：: R22;R40;

安全术语：: S36/37;S45;

分子结构式：

SDS：: 查看

二氯溴甲烷制备方法及用途

制备方法

用作溶剂、有机合成中间体。

用途简介

用途

用作溶剂、有机合成中间体。

二氯溴甲烷物化性质

密度：: 1.98 g/mL at 25 °C(lit.)
熔点：: −55 °C(lit.)
沸点：: 87 °C(lit.)
闪点：: 87-89°C
折射率：: n20/D 1.497(lit.)
存储条件/存储方法：: 库房通风低温干燥
稳定性相关：: 对机体有不可逆损伤的可能性。使用时应穿防护服、戴手套。
其它信息：: 1.      性状：无色液体。
2.      相对密度（g/mL,20/4℃）：1.980
3.      相对蒸汽密度（g/mL,空气=1）：未确定
4.      熔点（ºC）：-55
5.      沸点（ºC,常压）：87
6.      沸点（ºC,5.2kPa）：未确定
7.      折射率（20ºC）：1.4967
8.      气相标准声称热(焓)(kJ·mol^-1)：-48.8
9.      气相标准熵(J·mol^-1·K^-1)：316.30
10.     气相标准生成自由能(kJ·mol^-1)：-32.8
11.     气相标准热熔(J·mol^-1·K^-1)：67.62
12.   饱和蒸气压（kPa,60ºC）：未确定
13.   燃烧热（KJ/mol）：未确定
14.   临界温度（ºC）：未确定
15.   临界压力（KPa）：未确定
16.   油水（辛醇/水）分配系数的对数值：未确定
17.   爆炸上限（%,V/V）：未确定
18.   爆炸下限（%,V/V）：未确定
19.   溶解性：溶于乙醇、乙醚、丙酮、苯、氯仿，微溶于水。

二氯溴甲烷安全信息

包装等级：: III
风险类别：: 6.1
WGK_Germany：: 3
德国有关水污染物质的分类清单
危险类别码：: R22;R40
安全说明：: S26-S36/39-S45-S36/37-S16-S36/37/39
RTECS号：: PA5310000
安全标志：: S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
危险标志：: Xn:Harmful;

二氯溴甲烷毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PA5310000

CHEMICAL NAME :: Methane, bromodichloro-

CAS REGISTRY NUMBER :: 75-27-4

BEILSTEIN REFERENCE NO. :: 1697005

LAST UPDATED :: 199806

DATA ITEMS CITED :: 37

MOLECULAR FORMULA :: C-H-Br-Cl2

MOLECULAR WEIGHT :: 163.83

WISWESSER LINE NOTATION :: GYGE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Liver - fatty liver degeneration Blood - hemorrhage

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg/5D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5670 mg/kg/4W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 19500 mg/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9828 mg/kg/9W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20075 mg/kg/2Y-C

TOXIC EFFECTS :: Liver - fatty liver degeneration Liver - other changes Liver - changes in liver weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg/14D-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg/5D-I

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25500 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25500 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 51 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38250 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 750 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 umol/L

REFERENCE :: TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981- Volume(issue)/page/year: 13,205,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,179,1991 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,179,1991 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,179,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5772 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 3266 (estimated) No. of Female Employees: 502 (estimated)

毒理学数据：: 口服有害。对眼睛、呼吸系统及皮肤有刺激性。对机体有不可逆损伤的可能性。雄、雌小鼠经口LD50为450mg/kg、900mg/kg。

二氯溴甲烷 MSDS

国标编号:
ＣＡＳ:	75-27-4
中文名称:	一溴二氯甲烷
英文名称:	Monobromo-dichloro-methane；Bro
别名:	二氯溴甲烷
分子式:	CHBrCl₂；BrCHCl₂
分子量:	163.8
熔点:	-56.9℃
密度:	2.006
蒸汽压:
溶解性:	难溶于水，溶于醇、苯、醚等有机溶剂
稳定性:
外观与性状:	无色液体
危险标记:
用途:	来源：饮用水消毒产物

2.对环境的影响

一、健康危害
一溴二氯甲烷的毒性比三氯甲烷稍大，具有卤代烃化合物的共性，即对皮肤及粘膜有强烈的刺激性。能够经皮肤吸收后，侵蚀中枢神经，也作用于肺、心、肝、肾上腺和胃肠等内脏器管而引起中毒。
二、毒理学资料及环境行为
亚急性和慢性毒性：小鼠经口50mg/kg/日×14日肝肿大，体液免疫功能抑制；小鼠经口125mg/kg/日×14日肝肿大，血液葡萄糖含量下降，体液免疫功能抑制；小鼠经口250mg/kg/日×14日肝脾肿大，肝肾功能异常。
一溴二氯甲烷存在于水环境和底质环境中。环境监测结果表明，在饮用水中已被检出含有一溴二氯甲烷。尤其是经过加氯处理后的饮用水，该卤代烃污染物的含量，最高可达100μg/L左右。美国安全饮水委员会饮水调查结果表明，在饮用水源水中，一溴二氯甲烷的最高浓度为11μg/L，而在经过处理的水中最高浓度达到116μg/L。一般认为饮用水中这些卤化物是因为加氯过程中，消毒灭菌的同时，氯化了水体中天然存在的有机物质所生成的。

3.现场应急监测方法

直接进水样气相色谱法

4.实验室监测方法

吹扫捕集-气相色谱法(中国环境监测总站，水质)
气相色谱法《常见有毒化学品环境事故应急处置技术与监测方法》胡望钧主编
气相色谱法《固体废弃物试验与分析评价手册》中国环境监测总站等译

5.环境标准

美国(1981)饮用水(瓶装水)0.1mg/ L

6.应急处理处置方法

防止沾污扩散：为降低饮用水中一溴二氯甲烷，研究氯化前破坏或去除可被卤化的有机母体的方法，将可导致降低自来水中氯化产物及其对人类健康的危害。当饮用水水源中含有较高有机物质(微粒态或吸附在矿物微粒上的溶质)时，先混凝和过滤去除大量的有机物质，然后氯化处理，能直接减少包括一溴二氯甲烷在内的三卤甲烷的产生。

二氯溴甲烷分子结构与计算化学数据

分子结构数据

1、摩尔折射率：24.07

2、摩尔体积（cm³/mol）：81.3

3、等张比容（90.2K）：198.3

4、表面张力（dyne/cm）：35.3

5、极化率（10^-24cm³）：9.54

计算化学数据

1.疏水参数计算参考值（XlogP）:2.4

2.氢键供体数量:0

3.氢键受体数量:0

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:4

8.表面电荷:0

9.复杂度:13.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

二氯溴甲烷上游产品

三氯甲烷二氯甲烷新戊烷溴乙烷 2,2-二氯苯乙酮

二氯溴甲烷下游产品

溴化钠氯化钠二氯甲烷