巯嘌呤,50-44-2，生产厂家，价格-洛克化工网移动版

返回



基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

海关数据

结构与计算化学

上游产品

下游产品

表征图谱

巯嘌呤

中文名称：: 巯嘌呤

中文别名：: 6-巯基嘌呤;
埃博霉素A;
巯嘌呤;
6-嘌呤硫醇-水合物

英文名称：: mercaptopurine

英文别名：: mercaptopurine;
1,9-Dihydropurine-6-thione DISCONTINUED,see M225450;
6-Mercaptopurine;
1H-Purine-6(9H)-thione

CAS No.：: 50-44-2

分子式：: C₅H₄N₄S

分子量：: 152.18

精确分子量：: 152.01600

PSA：: 89.45000

EINECS：: 200-037-4

InChI：: InChI=1/C5H6N4/c1-4-5(8-2-6-1)9-3-7-4/h2-3H,1H2,(H,6,8)(H,7,9)3

危险品标志：

风险术语：

安全术语：

分子结构式：

SDS：: 查看

巯嘌呤制备方法及用途

制备方法

.2-巯基-4-氨基-6-羟基嘧啶的制备投料质量比为氰乙酸乙酯：硫脲：乙醇钠=1：0.75：3.75。无水乙醇和乙醇钠在干燥的反应器中搅拌加热至76℃，加入硫脲，回流下滴加氰乙酸乙酯，加完后回流4h，冷却至30℃。过滤，滤饼加3.5倍水溶解并用活性炭脱色，过滤，滤液加热至90℃，滴加40%乙酸至pH4-5，冷却过滤得产品。.氰乙酸乙酯[乙醇钠，硫脲，无水乙醇]→[76℃, 4h; 90℃, pH4-5]2-巯基-4-氨基-6-羟基嘧啶2-巯基-4，5-二氨基-6-羟基嘧啶的制备投料质量比为2-巯基-4-氨基-6-羟基嘧啶：盐酸(体积)：硝酸：亚硝酸钠：保险粉=1：0.31：0.47：0.48：2.5。将2-巯基-6-氨基-6-羟基嘧啶加水溶解，加入盐酸和硝酸，15℃滴加亚硝酸钠，加完后在pH3-4条件下反应2h，抽滤，滤饼水洗至中性，加入水中，冷至20℃以下加保险粉，25℃以下反应0.5h，35℃反应2h，抽滤得产品。2-硫基-4-氨基-6-羟基嘧啶[亚硝酸钠，盐酸，硝酸]→[2h, pH3-4]2-巯基-4-氨基-5-亚硝基-6-羟基嘧啶[连二亚硫酸钠]→[<25℃, 0.5h; 35℃, 2h]2-巯基-4,5-二氨基-6-羟基嘧啶4，5-二氨基-6-羟基嘧啶的制备投料质量比为2-巯基4，5-二氨基-6-羟基嘧啶：碳酸钠：活性镍：冰醋酸（体积）=1:0.75:1.5:1。将2-巯基-4，5-二氨基-6-羟基嘧啶和碳酸钠及适量水加热搅拌溶解，加入活性镍90-98℃回流4h。过滤，冰醋酸调滤液pH至7.5，减压浓缩后冷却抽滤得产品。2-巯基-4，5-二氨基-6-羟基嘧啶[碳酸钠，镍]→[90-98℃, 4h]4, 5-二氨基-6-羟基嘧啶6-巯基嘌呤的制备投料比为4，5-二氨基-6-羟基嘧啶(m)：甲酸(V)：吡啶(V)：五硫化二磷(m)=1：12：13：2.7。4，5-二氨基-6-羟基嘧啶和甲酸搅拌加热溶解后回流4h，减压回收甲酸，加6mol/L氢氧化钠溶液溶解，脱色过滤，滤液冷至20℃后，冰醋酸调pH6，放置过夜，过滤，将滤饼和吡啶及五硫化二磷投入反应器中加热溶解，118℃反应4h，减压回收吡啶，冷却，加水重结晶得粗品，粗晶用水重结晶得精品。4，5-二氨基-6-羟基嘧啶[甲酸，4h]→[五硫化二磷，118℃, 4h]6-巯基嘌呤。

合成制备方法

.2-巯基-4-氨基-6-羟基嘧啶的制备投料质量比为氰乙酸乙酯：硫脲：乙醇钠=1：0.75：3.75。无水乙醇和乙醇钠在干燥的反应器中搅拌加热至76℃，加入硫脲，回流下滴加氰乙酸乙酯，加完后回流4h，冷却至30℃。过滤，滤饼加3.5倍水溶解并用活性炭脱色，过滤，滤液加热至90℃，滴加40%乙酸至pH4-5，冷却过滤得产品。
.氰乙酸乙酯[乙醇钠，硫脲，无水乙醇]→[76℃, 4h; 90℃, pH4-5]2-巯基-4-氨基-6-羟基嘧啶
2-巯基-4，5-二氨基-6-羟基嘧啶的制备投料质量比为2-巯基-4-氨基-6-羟基嘧啶：盐酸(体积)：硝酸：亚硝酸钠：保险粉=1：0.31：0.47：0.48：2.5。将2-巯基-6-氨基-6-羟基嘧啶加水溶解，加入盐酸和硝酸，15℃滴加亚硝酸钠，加完后在pH3-4条件下反应2h，抽滤，滤饼水洗至中性，加入水中，冷至20℃以下加保险粉，25℃以下反应0.5h，35℃反应2h，抽滤得产品。
2-硫基-4-氨基-6-羟基嘧啶[亚硝酸钠，盐酸，硝酸]→[2h, pH3-4]2-巯基-4-氨基-5-亚硝基-6-羟基嘧啶[连二亚硫酸钠]→[<25℃, 0.5h; 35℃, 2h]2-巯基-4,5-二氨基-6-羟基嘧啶
4，5-二氨基-6-羟基嘧啶的制备投料质量比为2-巯基4，5-二氨基-6-羟基嘧啶：碳酸钠：活性镍：冰醋酸（体积）=1:0.75:1.5:1。将2-巯基-4，5-二氨基-6-羟基嘧啶和碳酸钠及适量水加热搅拌溶解，加入活性镍90-98℃回流4h。过滤，冰醋酸调滤液pH至7.5，减压浓缩后冷却抽滤得产品。
2-巯基-4，5-二氨基-6-羟基嘧啶[碳酸钠，镍]→[90-98℃, 4h]4, 5-二氨基-6-羟基嘧啶
6-巯基嘌呤的制备投料比为4，5-二氨基-6-羟基嘧啶(m)：甲酸(V)：吡啶(V)：五硫化二磷(m)=1：12：13：2.7。4，5-二氨基-6-羟基嘧啶和甲酸搅拌加热溶解后回流4h，减压回收甲酸，加6mol/L氢氧化钠溶液溶解，脱色过滤，滤液冷至20℃后，冰醋酸调pH6，放置过夜，过滤，将滤饼和吡啶及五硫化二磷投入反应器中加热溶解，118℃反应4h，减压回收吡啶，冷却，加水重结晶得粗品，粗晶用水重结晶得精品。
4，5-二氨基-6-羟基嘧啶[甲酸，4h]→[五硫化二磷，118℃, 4h]6-巯基嘌呤。

用途简介

用作抗肿瘤药。

用途

1.肿瘤药。治疗急、慢性白血病、绒毛膜上皮癌和恶性葡萄胎，对恶性淋巴病和多发性骨髓瘤也有疗效。不良反应主要有恶心、呕吐、食欲降低，有时有腹泻、口腔炎和口腔溃疡。用药期间应严格检查血象，并应进行肝功能检查。肝、肾功能不良者应减量慎用。与别嘌醇合用时，应将别嘌醇减量至原剂量的25%-50%。
2.该品为次黄嘌呤类干扰核合成的药物，又称抗代谢药物。阻止核酸的合成，制止癌细胞分裂繁殖，甚至因DNA合成受阻但蛋白质合成并不停止，因而发生不平衡生长，使癌细胞死亡。巯嘌呤属于周期特异性药物，主要作用于S期，对G1期也有延缓作用；对体液免疫和细胞免疫也有抑制作用。主要用于白血病。本品也是一种生化试剂。

巯嘌呤物化性质

外观与性状：
黄色结晶粉末

密度：
1.82g/cm3

熔点：
241-244°C

沸点：
471.018°C at 760 mmHg

闪点：
255.4ºC

折射率：
1.828

其它信息：

1.性状：本品为黄色结晶性粉末；无臭，味微甜。
2.熔点（°C）：241～244
3.溶解性：在水和乙醇中微溶解，在乙醚中几乎不溶。在140℃失去结晶水。易溶于碱性水溶液，但不稳定，缓慢水解，置空气中光照会变成黑色。可溶于沸水。

巯嘌呤安全信息

包装等级：
III

风险类别：
6.1(b)

海关代码：
2933599090

巯嘌呤毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UO9800000

CHEMICAL NAME :
Purine-6-thiol

CAS REGISTRY NUMBER :
50-44-2

LAST UPDATED :
199606

DATA ITEMS CITED :
114

MOLECULAR FORMULA :
C5-H4-N4-S

MOLECULAR WEIGHT :
152.19

WISWESSER LINE NOTATION :
T56 BM DN FN HNJ ISH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - man

DOSE/DURATION :
40 mg/kg/1W-I

TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
159 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
250 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Parenteral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
250 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
260 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
80 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
100 mg/kg

TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
80 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - hamster

DOSE/DURATION :
364 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
500 mg/kg/5D-I

TOXIC EFFECTS :
Related to Chronic Data - death

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - woman

DOSE/DURATION :
360 mg/kg/34W-C

TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
1820 mg/kg/2Y-C

TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
500 mg/kg/7W-I

TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors Skin and Appendages - tumors

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
1170 mg/kg/26W-I

TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :
TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - child

DOSE/DURATION :
675 mg/kg/39W-C

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
60 mg/kg

SEX/DURATION :
female 13 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
10 mg/kg

SEX/DURATION :
female 7-8 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
15 mg/kg

SEX/DURATION :
female 7-9 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
30 mg/kg

SEX/DURATION :
female 9 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
15 mg/kg

SEX/DURATION :
female 12 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
52500 ug/kg

SEX/DURATION :
female 11 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
5 mg/kg

SEX/DURATION :
female 9 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
1500 ug/kg

SEX/DURATION :
female 7-9 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - homeostasis

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
2250 ug/kg

SEX/DURATION :
female 7-9 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - abortion

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
5 mg/kg

SEX/DURATION :
female 10-14 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
40 mg/kg

SEX/DURATION :
female 11 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
5250 ug/kg

SEX/DURATION :
female 6-12 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Parenteral

DOSE :
1500 ug/kg

SEX/DURATION :
female 7-9 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - abortion Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Parenteral

DOSE :
1500 ug/kg

SEX/DURATION :
female 7-9 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Parenteral

DOSE :
50 mg/kg

SEX/DURATION :
female 13 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Unreported

DOSE :
3500 ug/kg

SEX/DURATION :
female 6-12 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - abortion Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
125 mg/kg

SEX/DURATION :
female 8-12 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
30 mg/kg

SEX/DURATION :
female 11 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
60 mg/kg

SEX/DURATION :
female 9 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
2 mg/kg

SEX/DURATION :
female 6-8 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
30 mg/kg

SEX/DURATION :
female 10 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
31500 ug/kg

SEX/DURATION :
female 3 day(s) pre-mating female 1-18 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - delayed effects

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
63 mg/kg

SEX/DURATION :
female 3 day(s) pre-mating female 1-18 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
25 mg/kg

SEX/DURATION :
female 11 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Parenteral

DOSE :
1500 ug/kg

SEX/DURATION :
female 6-8 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - abortion

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Parenteral

DOSE :
50 mg/kg

SEX/DURATION :
female 12 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Parenteral

DOSE :
60 mg/kg

SEX/DURATION :
female 11 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Unreported

DOSE :
1500 ug/kg

SEX/DURATION :
female 6-8 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - abortion

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Unreported

DOSE :
50 mg/kg

SEX/DURATION :
female 12 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
3 mg/kg

SEX/DURATION :
female 6-8 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
4 mg/kg

SEX/DURATION :
female 6-9 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - abortion Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
5 mg/kg

SEX/DURATION :
female 12-16 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
4 mg/kg

SEX/DURATION :
female 7-10 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
4 mg/kg

SEX/DURATION :
female 6-9 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intravenous

DOSE :
50 mg/kg

SEX/DURATION :
female 1 day(s) pre-mating

TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Parenteral

DOSE :
3 mg/kg

SEX/DURATION :
female 6-8 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - abortion Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Parenteral

DOSE :
3 mg/kg

SEX/DURATION :
female 6-8 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Parenteral

DOSE :
4 mg/kg

SEX/DURATION :
female 11-14 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Unreported

DOSE :
3 mg/kg

SEX/DURATION :
female 6-8 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - abortion Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
16 mg/kg

SEX/DURATION :
female 8 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
16 mg/kg

SEX/DURATION :
female 7 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
32 mg/kg

SEX/DURATION :
female 8 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - gastrointestinal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
48 mg/kg

SEX/DURATION :
female 10 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - homeostasis

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
2200 ug/kg

SEX/DURATION :
female 8-18 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
46200 ug/kg

SEX/DURATION :
female 8-18 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :
Cytogenetic analysis

TYPE OF TEST :
Micronucleus test

TYPE OF TEST :
Cytogenetic analysis

TYPE OF TEST :
Cytogenetic analysis

TYPE OF TEST :
Micronucleus test

TYPE OF TEST :
DNA inhibition

TYPE OF TEST :
Cytogenetic analysis

TYPE OF TEST :
Cytogenetic analysis

TYPE OF TEST :
Dominant lethal test

TYPE OF TEST :
Dominant lethal test

TYPE OF TEST :
Dominant lethal test

TYPE OF TEST :
Cytogenetic analysis

TYPE OF TEST :
Cytogenetic analysis
MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells

TEST SYSTEM :
Rodent - hamster Lung

DOSE/DURATION :
5 mg/L

REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 157,189,1985 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 26,249,1981 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 26,249,1981 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,240,1987 TOXICOLOGY REVIEW MIMDAL Minnesota Medicine. (Minnesota Medical Assoc., 2221 University Ave., SE, Suite 400, Minneapolis, MN 55414) V.1- 1918- Volume(issue)/page/year: 57,19,1974 TOXICOLOGY REVIEW JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 172,1765,1960 TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975 TOXICOLOGY REVIEW CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964 TOXICOLOGY REVIEW JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 144,429,1964 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7019 No. of Facilities: 58 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 699 (estimated) No. of Female Employees: 425 (estimated)

毒理学数据：

小鼠腹腔注射LD50为157mg/kg。

巯嘌呤 MSDS

  Material Safety Data Sheet

Section 1. Identiﬁcation of the substance
    Product Name:      6-Mercaptopurine
    Synonyms:        1,9-Dihydro-6h-purine-6-thione

Section 2. Hazards identiﬁcation
    Harmful by inhalation, in contact with skin, and if swallowed.

Section 3. Composition/information on ingredients.
    Ingredient name:        6-Mercaptopurine
    CAS number:        50-44-2

Section 4. First aid measures
    Skin contact:        Immediately wash skin with copious amounts of water for at least 15 minutes while removing
    contaminated clothing and shoes. If irritation persists, seek medical attention.
    Eye contact:        Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
    ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
    attention.
    Inhalation:        Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
    Ingestion:        Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section 5. Fire ﬁghting measures
    In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
    powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
    should be worn.

Section 6. Accidental release measures
    Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
    standards.
    Respiratory precaution:        Wear approved mask/respirator
    Hand precaution:        Wear suitable gloves/gauntlets
    Skin protection:        Wear suitable protective clothing
    Eye protection:        Wear suitable eye protection
    Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
    for disposal. See section 12.
    Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
    Handling:        This product should be handled only by, or under the close supervision of, those properly qualiﬁed
    in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
    health and chemical hazard data given on this sheet.
    Store in closed vessels.
    Storage:

Section 8. Exposure Controls / Personal protection
    Engineering Controls: Use only in a chemical fume hood.
    Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
    General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
    Appearance:        Not speciﬁed
    Boiling point:        No data
    No data
    Melting point:
    Flash point:        No data
    Density:        No data
    Molecular formula:        C5H4N4S
    Molecular weight:        152.2

Section 10. Stability and reactivity
    Conditions to avoid: Heat, ﬂames and sparks.
    Materials to avoid: Oxidizing agents.
    Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.

Section 11. Toxicological information
    No data.

Section 12. Ecological information
    No data.

Section 13. Disposal consideration
    Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
    disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
    Non-harzardous for air and ground transportation.

Section 15. Regulatory information
    No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
    302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
    Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

巯嘌呤海关数据

中国海关编码：2933599090

概述：

2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素：

品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

摘要/Summary：

2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

巯嘌呤分子结构与计算化学数据

计算化学数据

1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:2
3.氢键受体数量:2
4.可旋转化学键数量:0
5.互变异构体数量:8
6.拓扑分子极性表面积85.2
7.重原子数量:10
8.表面电荷:0
9.复杂度:190
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1

巯嘌呤上游产品

次黄嘌呤 6-氯嘌呤乙酐 6-Amino-5-formylamino-3H-pyrimidine-4-one

巯嘌呤下游产品

6-(丁基硫代)-嘌呤 6-(甲硫基)嘌呤 THIOURIC ACID 4-(1H-嘌呤-6-基)吗啉嘌呤; 7H-咪唑[4,5-d]嘧啶

巯嘌呤表征图谱

6-巯基嘌呤红外图谱(IR1)

6-巯基嘌呤红外图谱(IR2)

6-巯基嘌呤质谱(MS)

推荐供应商

湖北万得化工有限公司

6-巯基嘌呤
联系人：王念
电  话：027-59210159
手  机：15172311821
Cas号：50-44-2
包装：1t吨袋,200kg镀锌铁桶/塑料桶,25kg纸板桶/编织袋/塑料桶,10kg铝听/纸箱,1kg铝箔袋/氟化瓶
纯度：99%
价格：1.0元 - 1,000.0元
湖北齐飞医药化工有限公司

6-巯基嘌呤
联系人：朱梦蝶
电  话：027-59322506
手  机：18071128683
Cas号：50-44-2
包装：25kg纸板桶/编织袋/塑料桶
纯度：99%
价格：25.0元
湖北实顺生物科技有限公司

6-巯基嘌呤
联系人：张经理
电  话：027-59223025
手  机：15172526927
Cas号：50-44-2
包装：25kg纸板桶/编织袋/塑料桶
纯度：99%
价格：25.0元
湖北信康医药化工有限公司

巯嘌呤
联系人：张欢
电  话：027-59308705
手  机：18827031272
Cas号：50-44-2
包装：25kg纸板桶/编织袋/塑料桶
纯度：99%
价格：25.0元
湖北永阔科技有限公司

6-巯基嘌呤
联系人：徐
电  话：027-59223108
手  机：15107166787
Cas号：50-44-2
包装：25kg纸板桶/编织袋/塑料桶
纯度：99%
价格：25.0元
天门恒昌化工有限公司

6-巯基嘌呤
联系人：黄经理
电  话：027-59322316
手  机：15827039378
Cas号：50-44-2
包装：25kg纸板桶/编织袋/塑料桶
纯度：99%
价格：25.0元
湖北广奥生物科技有限公司

6-巯基嘌呤
联系人：孙经理
电  话：027-59223056
手  机：15271829679
Cas号：50-44-2
包装：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶,200kg镀锌铁桶/塑料桶,1t吨袋
纯度：99%
价格：1.0元 - 1,000.0元
湖北鑫红利化工有限公司

6-巯基嘌呤
联系人：周女士
电  话：027-59503710
手  机：18871490254
Cas号：50-44-2
包装：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶,200kg镀锌铁桶/塑料桶,1t吨袋
纯度：99%
价格：1.0元 - 1,000.0元
上海吉至生化科技有限公司

嘌呤-6-硫酮
联系人：江珊
电  话：021-57520831
手  机：15316869680
Cas号：50-44-2
包装：10gea,1gea,25gea,5gea
纯度：98%
价格：82.0元 - 687.0元
上海源叶生物科技有限公司

6-巯基嘌呤 (6-MP)
联系人：Yuki
电  话：021-61845781
手  机：13585604150
Cas号：50-44-2
包装：250mg,50mg
纯度：≥99%
价格：336.0元 - 800.0元

巯嘌呤

巯嘌呤 制备方法及用途

制备方法

合成制备方法

用途简介

用途

巯嘌呤 物化性质

巯嘌呤 安全信息

巯嘌呤 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

巯嘌呤 MSDS

巯嘌呤 海关数据

中国海关编码：2933599090

巯嘌呤 分子结构与计算化学数据

计算化学数据

巯嘌呤 上游产品

巯嘌呤 下游产品

巯嘌呤 表征图谱

推荐供应商

湖北万得化工有限公司

6-巯基嘌呤

湖北齐飞医药化工有限公司

6-巯基嘌呤

湖北实顺生物科技有限公司

6-巯基嘌呤

湖北信康医药化工有限公司

巯嘌呤

湖北永阔科技有限公司

6-巯基嘌呤

天门恒昌化工有限公司

6-巯基嘌呤

湖北广奥生物科技有限公司

6-巯基嘌呤

湖北鑫红利化工有限公司

6-巯基嘌呤

上海吉至生化科技有限公司

嘌呤-6-硫酮

上海源叶生物科技有限公司

6-巯基嘌呤 (6-MP)

巯嘌呤制备方法及用途

巯嘌呤物化性质

巯嘌呤安全信息

巯嘌呤毒理性

巯嘌呤海关数据

巯嘌呤分子结构与计算化学数据

巯嘌呤上游产品

巯嘌呤下游产品

巯嘌呤表征图谱