二嗪磷,333-41-5，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

海关数据

结构与计算化学

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二嗪磷

中文名称：: 二嗪磷

中文别名：: 二嗪磷;
0,0-二乙基-0-(2-异丙基-4-甲嘧啶-6-甲)硫逐磷酸酯;
O,O-二乙基-O-(2-异丙基-4-甲基嘧啶-6-基)硫代磷酸酯;
二嗪农;
敌匹硫磷;
大亚仙农;
地亚农

英文名称：: Diazinon

英文别名：: diazinon;
Diazinon AG500;
O,O-diethyl O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] phosphorothioate;
Antlak;
Anti;
O,O-diethyl O-2-isopropyl-6-methylpyrimidin-4-yl phosphorothioate;
Dicid;
Exodin;
dimpylate;
Dazzel;
dyzol;
G 301;
pt265;
Diazinon;
O,O-diethyl O-[6-methyl-2-(propan-2-yl)pyrimidin-4-yl] phosphorothioate;
AG-500

CAS No.：: 333-41-5

分子式：: C₁₂H₂₁N₂O₃PS

分子量：: 304.34

精确分子量：: 304.10100

PSA：: 95.37000

MDL：: MFCD00036204

EINECS：: 206-373-8

BRN：: 273790

InChI：: InChI=1/C4H4N2O/c7-4-2-1-3-5-6-4/h1-3H,(H,6,7)3

危险品标志：: Xn:
N :

风险术语：: R22;R50/53;

安全术语：: S24/25;S60;S61;

分子结构式：

SDS：: 查看

二嗪磷制备方法及用途

制备方法

1.将甲醇、氯化氢与异丁腈反应生成相应的亚氨酸酯盐酸盐;用氨处理,转化成相应的脒。然后,在碱性条件下,脒同乙酰乙酸乙酯缩合,得到嘧啶醇(4-羟基-2-异丙基-6-甲基嘧啶)。嘧啶醇在苯或甲苯中,在碳酸钠存在下加热回流,加入二乙基硫代磷酰氯、硝酸铜,缩合得到二嗪农。 2.将甲醇、氯化氢与异丁腈反应生成相应的亚氨酸酯盐酸盐;用氨处理得到异丁脒,在碱性条件下,异丁脒同乙酰乙酸乙酯缩合,得到嘧啶醇(4-羟基-2-异丙基-6-甲基嘧啶)。嘧啶醇在苯或甲苯中,在碳酸钠存在下加热回流,加入二乙基硫代磷酰氯、硝酸铜,缩合得到二嗪磷。 3.0,O一二乙基硫代磷醚氯的制备详见哇硫磷的合成。2一异丙基一4一甲基一6-羟基嘧啶的制备由异丁睛与甲醉和盐酸反应,制得业胺醚盐酸盐,再与氦作用制得异丁眯。异丁眯与乙醚乙酸乙酯在氢氧化钠存在下环化制得2一异丙基一4一甲基一6-羟基嘧啶。 4.二嚓磷的合成将撇2一异丙基一4一甲基一6-羟基嘧啶,0.638 SMB,2.828氢氧化钠、SOm工一丁酮混合后,在室温下搅拌O.Sh,缓慢升温至55 (' ,至物料澄清后加入9.5} O,O一二乙基硫代磷k4}氯,并升温至70 (' >搅拌O.Sh,再回流1h,搅冷,加入SOm工_水,使析出固体洛解,用20 0/} NaOH调竹pH值至11,搅拌、分层。水层用丁酮萃取,洛剂合并,减压脱洛,残留物经碱洗、酸洗、再碱洗后,水洗至中性,减压加热脱水,得14g棕色透明液液体,折射率1.49420

合成制备方法

1.将甲醇、氯化氢与异丁腈反应生成相应的亚氨酸酯盐酸盐；用氨处理，转化成相应的脒。然后，在碱性条件下，脒同乙酰乙酸乙酯缩合，得到嘧啶醇（4-羟基-2-异丙基-6-甲基嘧啶）。嘧啶醇在苯或甲苯中，在碳酸钠存在下加热回流，加入二乙基硫代磷酰氯、硝酸铜，缩合得到二嗪农。

2.将甲醇、氯化氢与异丁腈反应生成相应的亚氨酸酯盐酸盐；用氨处理得到异丁脒，在碱性条件下，异丁脒同乙酰乙酸乙酯缩合，得到嘧啶醇（4-羟基-2-异丙基-6-甲基嘧啶）。嘧啶醇在苯或甲苯中，在碳酸钠存在下加热回流，加入二乙基硫代磷酰氯、硝酸铜，缩合得到二嗪磷。

3.0,O一二乙基硫代磷醚氯的制备详见哇硫磷的合成。2一异丙基一4一甲基一6-羟基嘧啶的制备由异丁睛与甲醉和盐酸反应，制得业胺醚盐酸盐，再与氦作用制得异丁眯。异丁眯与乙醚乙酸乙酯在氢氧化钠存在下环化制得2一异丙基一4一甲基一6-羟基嘧啶。

4.二嚓磷的合成将撇2一异丙基一4一甲基一6-羟基嘧啶，0.638 SMB,2.828氢氧化钠、SOm工一丁酮混合后，在室温下搅拌O.Sh,缓慢升温至55 (' ,至物料澄清后加入9.5} O,O一二乙基硫代磷k4}氯，并升温至70 (' >搅拌O.Sh，再回流1h,搅冷，加入SOm工_水，使析出固体洛解，用20 0/} NaOH调竹pH值至11,搅拌、分层。水层用丁酮萃取，洛剂合并，减压脱洛，残留物经碱洗、酸洗、再碱洗后，水洗至中性，减压加热脱水，得14g棕色透明液液体，折射率1.49420

用途简介

1.是非内吸性杀虫剂,具有一定的杀螨作用。主要用于水稻、果树、葡萄、甘蔗、玉米、烟草和园艺植物上的食叶和刺吸式口器害虫 2.广谱性有机磷杀虫剂,具有触杀、胃毒、熏蒸作用,也有较好的杀螨与杀卵作用。用于防治苹果蠹虫,效果同对硫磷。防治蛴螬或金针虫比对硫磷更有效。除当作一般的触杀药剂以外,还可注射牛体,能灭杀牛瘤蝇的幼虫。对牲畜的毒性较小。可加工成可湿性粉剂、乳剂和粉剂使用。除含铜杀菌剂、碱性农药外,可与大多数农药混用。

用途

1.是非内吸性杀虫剂，具有一定的杀螨作用。主要用于水稻、果树、葡萄、甘蔗、玉米、烟草和园艺植物上的食叶和刺吸式口器害虫
2.广谱性有机磷杀虫剂，具有触杀、胃毒、熏蒸作用，也有较好的杀螨与杀卵作用。用于防治苹果蠹虫，效果同对硫磷。防治蛴螬或金针虫比对硫磷更有效。除当作一般的触杀药剂以外，还可注射牛体，能灭杀牛瘤蝇的幼虫。对牲畜的毒性较小。可加工成可湿性粉剂、乳剂和粉剂使用。除含铜杀菌剂、碱性农药外，可与大多数农药混用。

二嗪磷物化性质

外观与性状：
淡暗棕色液体

密度：
1.117

熔点：
>120°C (dec.)

沸点：
306°C

闪点：
104.4 °C

水溶解性：
Slightly soluble. 0.004 g/100 mL

折射率：
1.595

存储条件/存储方法：
库房通风低温干燥,与食品原料分开储运

稳定性相关：
对家兔皮肤和眼睛有轻度刺激作用。在试验剂量下，对动物无致畸、致癌、致突变作用。

其它信息：

一、物性数据
性状：无色油状物
密度（g/mL,25/4℃）：1.116-1.118
相对蒸汽密度（g/mL,空气=1）：不可用
熔点（ºC）：不可用
沸点（ºC,常压）：83-84
沸点（ºC,5.2kPa）：不可用
折射率： 1.498
闪点（ºC）：不可用
比旋光度（º）：不可用
自燃点或引燃温度（ºC）：不可用
蒸气压（kPa,25ºC）： 18700
饱和蒸气压（kPa,60ºC）：不可用
燃烧热（KJ/mol）：不可用
临界温度（ºC）：不可用
临界压力（KPa）：不可用
油水（辛醇/水）分配系数的对数值：不可用
爆炸上限（%,V/V）：不可用
爆炸下限（%,V/V）：不可用
溶解性：室温下，水中溶解度为40mg/L(40ppm)，可与乙醇、丙酮、二甲苯混溶，可溶于甘油

二嗪磷安全信息

包装等级：
III

风险类别：
6.1(b)

海关代码：
2933599011

危险类别码：
R22;R50/53

安全说明：
S24/25-S60-S61-S36-S26-S16

RTECS号：
TF3325000

安全标志：
S60:本物质残余物和容器必须作为危险废物处理。
S61:避免排放到环境中。参考专门的说明/安全数据表。
S24/25:防止皮肤和眼睛接触。

危险标志：
Xn:Harmful

二嗪磷毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TF3325000

CHEMICAL NAME :
Phosphorothioic acid, O,O-diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) ester

CAS REGISTRY NUMBER :
333-41-5

BEILSTEIN REFERENCE NO. :
0273790

LAST UPDATED :
199712

DATA ITEMS CITED :
99

MOLECULAR FORMULA :
C12-H21-N2-O3-P-S

MOLECULAR WEIGHT :
304.38

WISWESSER LINE NOTATION :
T6N CNJ BY1&1 DOPS&O2&O2 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test

ROUTE OF EXPOSURE :
Administration onto the skin

SPECIES OBSERVED :
Rodent - rabbit

TYPE OF TEST :
Standard Draize test

ROUTE OF EXPOSURE :
Administration into the eye

SPECIES OBSERVED :
Rodent - rabbit

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human

DOSE/DURATION :
214 mg/kg

TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Skin and Appendages - sweating

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
66 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
3500 mg/m3/4H

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Administration onto the skin

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
180 mg/kg

TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
65 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
17 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
1600 mg/m3/4H

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Administration onto the skin

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
2750 mg/kg

TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
33 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
58 mg/kg

TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - reactivates cholinesterase

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
180 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
143 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Administration onto the skin

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
3600 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - pig

DOSE/DURATION :
320 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Administration onto the skin

SPECIES OBSERVED :
Mammal - pig

DOSE/DURATION :
633 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - guinea pig

DOSE/DURATION :
250 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - guinea pig

DOSE/DURATION :
5500 mg/m3/4H

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Bird - pigeon

DOSE/DURATION :
3160 ug/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Bird - chicken

DOSE/DURATION :
8400 ug/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Bird - quail

DOSE/DURATION :
4210 ug/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Bird - duck

DOSE/DURATION :
3500 ug/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Unreported

SPECIES OBSERVED :
Mammal - species unspecified

DOSE/DURATION :
76 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Bird - wild bird species

DOSE/DURATION :
2 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
201 ug/m3/24H/13W-C

TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
46 mg/kg/92D-I

TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
86 mg/kg/30D-C

TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
91 mg/kg/26W-C

TOXIC EFFECTS :
Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
371 mg/kg/14D-C

TOXIC EFFECTS :
Blood - change in clotting factors

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
28 mg/kg/28W-I

TOXIC EFFECTS :
Liver - fatty liver degeneration Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
1095 mg/kg/2Y-C

TOXIC EFFECTS :
Endocrine - changes in thyroid weight Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
98 mg/kg/28W-I

TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
26280 mg/kg/2Y-C

TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - dog

DOSE/DURATION :
4900 mg/kg/35W-I

TOXIC EFFECTS :
Gastrointestinal - other changes Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - dog

DOSE/DURATION :
1200 mg/kg/46W-I

TOXIC EFFECTS :
Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - dog

DOSE/DURATION :
157 mg/kg/12W-C

TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - dog

DOSE/DURATION :
3395 mg/kg/1Y-C

TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Administration onto the skin

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
210 mg/kg/21D-I

TOXIC EFFECTS :
Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - pig

DOSE/DURATION :
2450 mg/kg/35W-I

TOXIC EFFECTS :
Gastrointestinal - other changes Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
26400 ug/kg

SEX/DURATION :
female 12-15 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
45 mg/kg

SEX/DURATION :
female 8-12 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
63500 ug/kg

SEX/DURATION :
female 10 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
100 mg/kg

SEX/DURATION :
female 11 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
150 mg/kg

SEX/DURATION :
female 11 day(s) after conception

TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
200 mg/kg

SEX/DURATION :
female 11 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
3960 ug/kg

SEX/DURATION :
female 1-22 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - delayed effects

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
189 mg/kg

SEX/DURATION :
female 1-21 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - endocrine system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
3780 ug/kg

SEX/DURATION :
female 1-21 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
210 ug/kg

SEX/DURATION :
female 1-21 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system Reproductive - Effects on Newborn - delayed effects

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
189 mg/kg

SEX/DURATION :
female 1-21 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
130 mg/kg

SEX/DURATION :
female 6-18 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
570 mg/kg

SEX/DURATION :
female 1-16 week(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
Mutation test systems - not otherwise specified

TYPE OF TEST :
DNA inhibition

TYPE OF TEST :
Sister chromatid exchange
MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis

TEST SYSTEM :
Rodent - hamster Lung

REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,277,1979 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.1 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued. Volume(issue)/page/year: #73-19,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966- Volume(issue)/page/year: 10(3),43,1975 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.1 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,780,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.1 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.1 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 0.1 mg/m3;STEL 0.3 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 0.1 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 0.1 mg/m3;Skin JAN 1993 OEL-HUNGARY:STEL 0.1 mg/m3;Skin JAN 1993 OEL-INDIA:TWA 0.1 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 mg/m3;Skin JAN 1993 OEL-RUSSIA:STEL 0.2 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 mg/m3;STEL 0.3 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIAZINON-air:10H TWA 0.1 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 23360 No. of Facilities: 1268 (estimated) No. of Industries: 9 No. of Occupations: 9 No. of Employees: 26581 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 23360 No. of Facilities: 3168 (estimated) No. of Industries: 10 No. of Occupations: 18 No. of Employees: 39342 (estimated) No. of Female Employees: 3216 (estimated)

毒理学数据：

二、毒理学数据：
急性毒性：LD50：76 mg/kg(大鼠经口)；85 mg/kg(小鼠经口) 。

生态数据：

三、生态学数据：
1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。

二嗪磷 MSDS

第一部分：化学品名称

二嗪磷海关数据

中国海关编码：2933599011

概述：

2933599011 嘧啶磷,甲基嘧啶磷,二嗪磷，双苯嘧草酮等〔包括嘧啶氧磷,乙嘧硫磷〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%

申报要素：

品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

监管条件：

S.进出口农药登记证明

摘要/Summary：

2933599011 o-(2-(diethylamino)-6-methylpyrimidin-4-yl) o,o-dimethyl phosphorothioate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

二嗪磷分子结构与计算化学数据

分子结构数据

1、   摩尔折射率：79.64
2、   摩尔体积（cm³/mol）：260.4
3、   等张比容（90.2K）：677.2
4、   表面张力（dyne/cm）：45.6
5、   极化率（10^-24cm³）：31.57

计算化学数据

1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:0
3.氢键受体数量:6
4.可旋转化学键数量:7
5.互变异构体数量:3
6.拓扑分子极性表面积85.6
7.重原子数量:19
8.表面电荷:0
9.复杂度:307
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1

二嗪磷上游产品

 O,O-二乙基硫代磷酰氯 2-异丙基-4-甲基-6-羟基嘧啶

二嗪磷下游产品

2,2'-(乙烯二氧)双(乙胺) 2-异丙基-4-甲基-6-羟基嘧啶 N,N-二乙基氨基甲酸乙酯二嗪磷氧同系物

二嗪磷表征图谱

二嗪农核磁图(¹³CNMR)

二嗪农核磁图(¹HNMR)

二嗪农红外图谱(IR1)

二嗪农质谱(MS)

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二嗪磷

二嗪磷 制备方法及用途

制备方法

合成制备方法

用途简介

用途

二嗪磷 物化性质

二嗪磷 安全信息

二嗪磷 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

二嗪磷 MSDS

二嗪磷 海关数据

中国海关编码：2933599011

二嗪磷 分子结构与计算化学数据

分子结构数据

计算化学数据

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