2-(二乙氨基)乙醇
- 中文名称：
- 2-(二乙氨基)乙醇
- 中文别名：
- 二乙氨基乙醇;
N,N-二乙基乙醇胺
- 英文名称：
- Ethanol,2-(diethylamino)-
- 英文别名：
- 2-diethylaminoethanol;
2-(Diethylamino)ethanol;
N,N-Diethylethanolamine;
2-(diethylamino)ethanol;
Diethylaminoethanol
- CAS No.：
- 100-37-8
- 分 子 式：
-
C6H15NO
- 分 子 量：
- 117.19
- 精确分子量：
- 117.11500
- PSA：
- 23.47000
- MDL：
- MFCD00002850
- EINECS：
- 202-845-2
- BRN：
- 741863
- InChI：
- InChI=1/C6H15NO/c1-4-7(5-2)6(3)8/h6,8H,4-5H2,1-3H33
- 危险品标志：
-
C
C- 分子结构式：
-
- SDS：
- 查看
2-(二乙氨基)乙醇 制备方法及用途
制备方法
-
1.将氯乙醇与氢氧化钠在105℃下进行反应，生成环氧乙烷，通入二乙胺溶液中进行反应，在常压下分出低沸物后，减压分馏得N，N-二乙基乙醇胺成品。目前大部分生产厂直接用环氧乙烷作原料。精制方法：常压或减压蒸馏精制。
2.以二乙胺和环氧乙烷原料，将环氧乙烷加入二乙胺中，在一定温度下反应，所得粗品经减压蒸馏成纯品。反应式如下：
合成制备方法
1.将氯乙醇与氢氧化钠在105℃下进行反应，生成环氧乙烷，通入二乙胺溶液中进行反应，在常压下分出低沸物后，减压分馏得N，N-二乙基乙醇胺成品。目前大部分生产厂直接用环氧乙烷作原料。
精制方法：常压或减压蒸馏精制。
2.以二乙胺和环氧乙烷原料，将环氧乙烷加入二乙胺中，在一定温度下反应，所得粗品经减压蒸馏成纯品。反应式如下：
用途简介
-
医药中间体，用于合成盐酸普鲁卡因、乙胺香豆素盐酸盐、咳美芬、咳必清、胃复康、优托品等。也可用于制取脂肪酸衍生物、纤维柔软剂、防锈剂、乳化剂等。
用途
1.用作医药中间体、软化剂、乳化剂、固化剂等。2-（二乙氨基）乙醇除用作普洛卡因等医药原料之外，还可用作防腐剂、中和剂、树脂固化剂、照相显影液和定影液添加剂等。与高级脂肪酸生成的胺皂，可作乳化剂、纤维处理剂。
2.是有效的除氧剂和钝化剂。可与二乙基羟胺复配用于锅炉水处理中，二乙氨基乙醇还可用作合成树脂固化剂、纺织品软化剂、酸性介质和乳化剂、防锈剂组分。
3.用于有机合成，用作织物软化剂。[21]
2-(二乙氨基)乙醇 物化性质
- 外观与性状：
- 透明至淡黄色液体
- 密度：
- 0.884 g/mL at 25 °C(lit.)
- 熔点：
- -70 °C
- 沸点：
- 161 °C(lit.)
- 闪点：
- 120 °F
- 水溶解性：
- soluble
- 折射率：
- n20/D 1.441(lit.)
- 蒸汽压：
- 2.229mmHg at 25°C
- 蒸汽密度：
- 4.04 (vs air)
- 存储条件/存储方法：
- 库房通风低温干燥,与氧化剂,酸类分开储运
- 稳定性相关：
1.化学性质：具有叔胺和醇的化学反应性。用过氧化氢、高锰酸钾等氧化时，生成乙醇、乙酸、乙酰氧肟酸、氨、乙二醛和草酸等。用四乙酸铅氧化时，生成二乙胺与乙二醇醛。用硫代硫酸钾室温氧化生成乙醛。并可形成盐酸盐C6H15NO·HCl（熔点135~136℃），苦味酸盐［C6H15NO·C6H3N3O7（熔点79℃）］。
2.稳定性[17] 稳定
3.禁配物[18] 强氧化剂、强酸
4.聚合危害[19] 不聚合
- 其它信息：
1.性状：无色吸湿性液体，有氨味。[1]
2.熔点（℃）：-70[2]
3.沸点（℃）：163[3]
4.相对密度（水=1）：0.88[4]
5.相对蒸气密度（空气=1）：4.03[5]
6.饱和蒸气压（kPa）：2.8（20℃）[6]
7.辛醇/水分配系数：0.31[7]
8.闪点（℃）：52（CC）；60（OC）[8]
9.引燃温度（℃）：320[9]
10.爆炸上限（%）：11.7[10]
11.爆炸下限（%）：6.7[11]
12.溶解性：与水混溶，溶于乙醇、乙醚、苯、丙酮等多数有机溶剂。[12]
13.折射率（20ºC）：1.4412
14.黏度（mPa·s,20ºC）：3.5
15.黏度（mPa·s,25ºC）：4.05
16.黏度（mPa·s,60ºC）：1.50
17.蒸气压（kPa,55ºC）：1.33
18.蒸气压（kPa,100ºC）：10.67
19.燃烧热（KJ/mol）：4198.1
20.生成热（KJ/mol）：309.8
2-(二乙氨基)乙醇 安全信息
- 包装等级：
- II
- 风险类别：
- 8
- 海关代码：
- 2922192210
- WGK_Germany：
- 1
德国有关水污染物质的分类清单 - 危险类别码：
- R10;R20/21/22;R34
- 安全说明：
- S25-S26-S36/37/39-S45
- RTECS号：
- KK5075000
- 安全标志：
- S25:避免接触眼睛。
S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
: - 危险标志：
- C:Corrosive
2-(二乙氨基)乙醇 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KK5075000
- CHEMICAL NAME :
- Ethanol, 2-(diethylamino)-
- CAS REGISTRY NUMBER :
- 100-37-8
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 46
- MOLECULAR FORMULA :
- C6-H15-N-O
- MOLECULAR WEIGHT :
- 117.22
- WISWESSER LINE NOTATION :
- Q2N2&2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/11/1963
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/11/1963 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 200 ppm
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
- REFERENCE :
- 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,216,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4500 mg/m3/4H
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 14(11),52,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1220 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 12,486,1968
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5000 mg/m3
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 14(11),52,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 192 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 94,249,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 650 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,31,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 188 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,31,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 416 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,31,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1260 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/11/1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 1300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,216,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 ppm/6H/5D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Related to Chronic Data - death
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 26,479,1965
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 ppm/6H/26W-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 26,479,1965
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 76 ppm/6H/14W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,418,1992
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 301 ppm/6H/2W-I
- TOXIC EFFECTS :
- Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,418,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 21559 mg/kg/1Y-C
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530455-1 *** REVIEWS *** ACGIH TLV-TWA 9.6 mg/m3 (2 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 10 ppm (50 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,85,1971 OSHA PEL (Gen Indu):8H TWA 10 ppm (50 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 10 ppm (50 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 10 ppm (50 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 10 ppm (50 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 10 ppm (48 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-FINLAND:STEL 10 ppm (50 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 2-DIETHYLAMINOETHANOL-air:10H TWA 10 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 24930 No. of Facilities: 7801 (estimated) No. of Industries: 71 No. of Occupations: 39 No. of Employees: 23770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 24930 No. of Facilities: 11825 (estimated) No. of Industries: 115 No. of Occupations: 68 No. of Employees: 106878 (estimated) No. of Female Employees: 20564 (estimated)
- 毒理学数据：
1.急性毒性[13]
LD50：1300mg/kg（大鼠经口）；1260mg/kg（兔经皮）
2.刺激性[14]
家兔经皮：500mg，轻度刺激（开放性刺激试验）。
家兔经眼：5mg，重度刺激。
- 生态数据：
1.生态毒性[15] LC50：1780mg/L（96h）（黑头呆鱼）；＞1000mg/L（96h）（青鳉）
2.生物降解性 暂无资料
3.非生物降解性 暂无资料
4.其他有害作用[16] 该物质对环境可能有危害，对水体应给予特别注意。
2-(二乙氨基)乙醇 MSDS
| Name: | N N-Diethylethanolamine P.A. Material Safety Data Sheet |
| Synonym: | 2-Diethylaminoethanol, Beta-Diethylaminoethano |
| CAS: | 100-37-8 |
Synonym:2-Diethylaminoethanol, Beta-Diethylaminoethano
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | content | EINECS# |
| 100-37-8 | N,N-Diethylethanolamine | 99.0 | 202-845-2 |
Risk Phrases: 10 36/37/38
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Flammable. Irritating to eyes, respiratory system and skin.Hygroscopic.
Potential Health Effects
Eye:
May cause eye irritation. May cause eye injury.
Skin:
May cause severe skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Vapors may cause dizziness or suffocation. May cause nausea and possible vomiting.
Chronic:
None
Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Antidote: None reported.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Do NOT get water inside containers. For large fires, use water spray, fog or alcohol-resistant foam. Cool containers with flooding quantities of water until well after fire is out.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Use water spray to disperse the gas/vapor. Remove all sources of ignition. Use a spark-proof tool.
Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use only in a well-ventilated area.
Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame.
Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Store protected from moisture.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Appearance: clear yellow brown
Odor: unpleasant odor
pH: Not available.
Vapor Pressure: 1.9 mbar @ 20 C
Viscosity: 5mPa @ 20C
Boiling Point: 161 deg C @ 760.00mm Hg
Freezing/Melting Point: -70 deg C
Autoignition Temperature: 260 deg C ( 500.00 deg F)
Flash Point: 60 deg C ( 140.00 deg F)
Explosion Limits, lower: 6.70 vol %
Explosion Limits, upper: 11.7 vol %
Decomposition Temperature:
Solubility in water: soluble
Specific Gravity/Density: .8840g/cm3
Molecular Formula: C6H15NO
Molecular Weight: 117.19
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat, strong oxidants, exposure to moist air or water.
Incompatibilities with Other Materials:
Moisture.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 100-37-8: KK5075000 LD50/LC50:
CAS# 100-37-8: Dermal, guinea pig: LD50 = 1 mL/kg; Draize test, rabbit, eye: 5 mg Severe; Inhalation, mouse: LC50 = 5000 mg/m3; Oral, rat: LD50 = 1300 mg/kg; Skin, rabbit: LD50 = 1260 uL/kg.
Carcinogenicity:
N,N-Diethylethanolamine - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Fathead Minnow: 1780 mg/L; 96 Hr.; Flow-through
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: 2-DIETHYLAMINOETHANOL
Hazard Class: 8
UN Number: 2686
Packing Group: II
IMO
Shipping Name: DIETHYLAMINOETHANOL
Hazard Class: 3.3
UN Number: 2686
Packing Group: III
RID/ADR
Shipping Name: DIETHYLAMINOETHANOL
Dangerous Goods Code: 3(31C)
UN Number: 2686
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 10 Flammable.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
WGK (Water Danger/Protection)
CAS# 100-37-8: 1
United Kingdom Occupational Exposure Limits
CAS# 100-37-8: OES-United Kingdom, TWA 10 ppm TWA; 49 mg/m3 TWA
Canada
CAS# 100-37-8 is listed on Canada's DSL List.
CAS# 100-37-8 is listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 100-37-8: OEL-AUSTRALIA:TWA 10 ppm (50 mg/m3);Skin
OEL-AUSTRIA:TWA 10 ppm (50 mg/m3);Skin
OEL-BELGIUM:TWA 10 ppm (48 mg/m3);Skin
OEL-DENMARK:TWA 10 ppm (50 mg/m3);Skin
OEL-FINLAND:STEL 10 ppm (50 mg/m3);Skin
OEL-FRANCE:TWA 10 ppm (50 mg/m3);Skin
OEL-GERMANY:TWA 10 ppm (50 mg/m3);Skin
OEL-THE NETHERLANDS:TWA 10 ppm (50 mg/m3);Skin
OEL-THE PHILIPPINES:TWA 10 ppm (50 mg/m3);Skin
OEL-RUSSIA:STEL 5 mg/m3;Skin
OEL-SWITZERLAND:TWA 10 ppm (50 mg/m3);Skin
OEL-UNITED KINGDOM:TWA 10 ppm (50 mg/m3);Skin
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 100-37-8 is listed on the TSCA inventory.
SECTION 16 - ADDITIONAL INFORMATION
N/A
2-(二乙氨基)乙醇 海关数据
中国海关编码：2922192210
- 概述：
- 2922192210 2－二乙氨基乙醇〔或称N,N－二乙基乙醇胺〕。监管条件:3(两用物项和技术出口许可证)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%
- 申报要素：
- 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
- 监管条件：
- 3.两用物项和技术出口许可证
- 摘要/Summary：
- 2922192210 2-(diethylamino)ethanol。supervision conditions:3(export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%
2-(二乙氨基)乙醇 分子结构与计算化学数据
分子结构数据
1、摩尔折射率：35.10
2、摩尔体积（cm3/mol）：132.3
3、等张比容（90.2K）：313.2
4、表面张力（dyne/cm）：31.4
5、极化率：13.91
计算化学数据
1.疏水参数计算参考值（XlogP）:0.3
2.氢键供体数量:1
3.氢键受体数量:2
4.可旋转化学键数量:4
5.互变异构体数量:无
6.拓扑分子极性表面积23.5
7.重原子数量:8
8.表面电荷:0
9.复杂度:43.8
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
