环孢素,59865-13-3，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

结构与计算化学

下游产品

环孢素

中文名称：: 环孢素

中文别名：: 环孢菌素;
环胞霉素A;
环孢霉素A

英文名称：: ciosporin

英文别名：: Cyclosporin A;
cyclosporin A;
s7481f1;
Neoral;
Atopica;
sandimmun neoral;
ciclosporin A;
Restasis;
Cipol N;
cyclosporine A;
sandimmun;
ol27-400;
Neoplanta;
Sandimmun optoral;
Optimmune

CAS No.：: 59865-13-3

分子式：: C₆₂H₁₁₁N₁₁O₁₂

分子量：: 1202.62

精确分子量：: 1201.84137

PSA：: 279 A2

MDL：: MFCD00274558

BRN：: 3647785

InChI：: The Key: PMATZTZNYRCHOR-IMVLJIQESA-N3

危险品标志：: Xn

风险术语：: R45;R60;R22;

安全术语：: S53;S45;

分子结构式：

SDS：: 查看

环孢素制备方法及用途

制备方法

1.以多孢木霉菌(Tolypocladium inflatum Cams)为生产菌株。75L罐内装50L种子培养基,接种5×109个孢子,Ph=5.4—4.3,培养72h,得到一级种子液。750L发酵罐内装500L发酵培养基,种入上述一级种子液,培养6天,得二级种子液。4500L发酵罐内装3000L发酵培养基,发酵12天,得到环孢素发酵毒。往发酵液中加人等体积的乙酸乙酯提取,分出有机层,减压蒸发,得粗品。融化处理,可得环孢素和环孢菌素C组分,其中环孢素的产量约为150～200mg/L环孢菌素C约为50～100mg/L。 2.以多孢木霉菌为生产菌株。先制备环孢素发酵液。向发酵液中加入乙酸乙酯提取,分出有机层,减压蒸发,得粗品。经纯化处理可得。

合成制备方法

1.以多孢木霉菌(Tolypocladium inflatum Cams)为生产菌株。75L罐内装50L种子培养基，接种5×10⁹个孢子，Ph=5.4—4.3，培养72h，得到一级种子液。750L发酵罐内装500L发酵培养基，种入上述一级种子液，培养6天，得二级种子液。4500L发酵罐内装3000L发酵培养基，发酵12天，得到环孢素发酵毒。往发酵液中加人等体积的乙酸乙酯提取，分出有机层，减压蒸发，得粗品。融化处理，可得环孢素和环孢菌素C组分，其中环孢素的产量约为150～200mg/L环孢菌素C约为50～100mg/L。

2.以多孢木霉菌为生产菌株。先制备环孢素发酵液。向发酵液中加入乙酸乙酯提取，分出有机层，减压蒸发，得粗品。经纯化处理可得。

用途简介

优级纯。

用途

1.新型免疫抑制剂。为由十一个氨基酸组成的环状多肽物质。它抑制体液和细胞传递的免疫功能，而不抑制骨髓，不减少白细胞数。能阻止对移植组织或器官的排斥作用。临床用于肾移植，肝、肺移植及心脏移植，另外，对自身免疫疾病，以及血吸虫病、疟疾、糖尿病、艾滋病等有一定疗效，还有抗炎症性能。
2.治疗白血病、癌、肾移植、结核病等。
3.免疫抑制剂。由十一个氨基酸组成的环状多肽物质。可抑制淋巴细胞生成干扰素。它对网状内皮系统吞噬细胞无影响。环孢素不同于细胞毒类药物的作用，它仅抑制Ｔ细胞介导的细胞免疫而不致显著影响机体的一般防御能力。它抑制体液和细胞传递的免疫功能，而不抑制骨髓，不减少白细胞数。能阻止对移植组织或器官的排斥作用。另外，它对自身免疫疾病以及血吸虫病、疟疾、糖尿病、艾滋病等有一定
疗效，还有抗炎症性能。环孢素在临床上主要用于防止异体器官或骨髓移植时
排异等不利的免疫反应，常和糖皮质激素合用。

环孢素物化性质

外观与性状：
从-15℃的丙酮得白色针状结晶，熔点148～151℃，[α]D20-244°(C=0.6，氯仿)。溶于甲醇、乙醇、丙酮、乙醚或氯仿，微溶于水及饱和碳氢化合物。急性毒性LD50小鼠，大鼠，兔子(mg/kg)：107，25，＞10静脉注射；2329，1480，＞1000口服。

密度：
1.016±0.06 g/cm3

熔点：
137-140 °C (decomp)

沸点：
1293.8±65.0 °C

闪点：
736.3±34.3 °C

水溶解性：
Very Soluble (1000 g/L)

蒸汽密度：
0 Torr

存储条件/存储方法：
2-8°C

稳定性相关：

从-15℃的丙酮得白色针状结晶，熔点148～151℃，[α]_D²⁰-244°(C=0.6，氯仿)。溶于甲醇、乙醇、丙酮、乙醚或氯仿，微溶于水及饱和碳氢化合物。急性毒性LD₅₀小鼠，大鼠，兔子(mg/kg)：107，25，＞10静脉注射；2329，1480，＞1000口服。

其它信息：

1.       性状：白色针状结晶，从－15℃的丙酮中得到。
2.       密度（g/cm³，25 ºC）：未确定
3.       相对蒸汽密度（g/mL,空气=1）：未确定
4.       熔点（ºC）：148-151
5.       沸点（ºC）：未确定
6.       沸点（ºC,5.2kPa）：未确定
7.       折射率（°）：未确定
8.       闪点（℉）：未确定
9.       比旋光度（º）：未确定
10.    自燃点或引燃温度（ºC）：未确定
11.    蒸气压（kPa,25ºC）：未确定
12.    饱和蒸气压（kPa,60ºC）：未确定
13.    燃烧热（KJ/mol）：未确定
14.    临界温度（ºC）：未确定
15.    临界压力（KPa）：未确定
16.    油水（辛醇/水）分配系数的对数值（25℃）：未确定
17.    爆炸上限（%,V/V）：未确定
18.    爆炸下限（%,V/V）：未确定
19.    溶解性(mg/mL)：溶于甲醇、乙醇、丙酮、乙醚或氯仿，微溶于水。

环孢素安全信息

海关代码：
2941909000

WGK_Germany：
3
德国有关水污染物质的分类清单

危险类别码：
R45;R60;R22

安全说明：
53-45-36/37-24/25-22

RTECS号：
GZ4120000

安全标志：
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S53:避免暴露——使用前先阅读专门的说明。

危险标志：
T:Toxic

环孢素毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GZ4120000

CHEMICAL NAME :
Cyclosporin A

CAS REGISTRY NUMBER :
59865-13-3

LAST UPDATED :
199801

DATA ITEMS CITED :
35

MOLECULAR FORMULA :
C62-H111-N11-O12

MOLECULAR WEIGHT :
1202.84
HEALTH HAZARD DATA
ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - woman

DOSE/DURATION :
1911 mg/kg/91W-I

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - coma Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - woman

DOSE/DURATION :
62500 ug/kg/5D-I

TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - man

DOSE/DURATION :
20 mg/kg/2D-I

TOXIC EFFECTS :
Behavioral - headache Vascular - acute arterial occlusion Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human

DOSE/DURATION :
12 mg/kg

TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section Endocrine - antidiuresis

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Unreported

SPECIES OBSERVED :
Human - man

DOSE/DURATION :
30 mg/kg/4D-I

TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
1480 mg/kg

TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
147 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
286 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
24 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
2329 mg/kg

TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
96 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
>1 gm/kg

TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
10 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
140 mg/kg/14D-I

TOXIC EFFECTS :
Endocrine - changes in spleen weight Blood - changes in spleen

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
350 mg/kg/7D-I

TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
800 mg/kg/10D-I

TOXIC EFFECTS :
Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
420 mg/kg/28D-I

TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal - other changes

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
700 mg/kg/28D-I

TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
210 mg/kg/14D-I

TOXIC EFFECTS :
Kidney, Ureter, Bladder - renal function tests depressed Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
1200 mg/kg/40D-I

TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
140 mg/kg/7D-I

TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section Vascular - regional or general arteriolar or venous dilation

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
60 mg/kg/3D-I

TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section Vascular - structural changes in vessels Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - man

DOSE/DURATION :
259 mg/kg/2W-C

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
166 mg/kg

SEX/DURATION :
male 45 day(s) pre-mating

TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
420 mg/kg

SEX/DURATION :
male 14 day(s) pre-mating

TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

DOSE :
560 mg/kg

SEX/DURATION :
male 14 day(s) pre-mating

TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
90 mg/kg

SEX/DURATION :
female 6-8 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
50 mg/kg

SEX/DURATION :
female 12 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intramuscular

DOSE :
210 mg/kg

SEX/DURATION :
female 14 day(s) pre-mating

TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - other measures of fertility
MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange

TEST SYSTEM :
Human Lymphocyte

DOSE/DURATION :
1 mg/L

REFERENCE :
IGAYAY Igaku No Ayumi. Progress in Medicine. (Ishiyaku Shuppan K.K., 1-7-10, Honkomagom, Bunkyo-ku, Tokyo, Japan) V.1- 1946- Volume(issue)/page/year: 134,403,1985 *** REVIEWS *** IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,77,1990 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,77,1990 IARC Cancer Review:Group 1 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,77,1990

毒理学数据：

小鼠，大鼠，兔子静脉注射LD50(mg/kg):107、25、＞10;经口：2329、1480、＞1000。

生态数据：

对水是稍微危害的，若无政府许可，勿将材料排入周围环境。

环孢素 MSDS

  Cyclosporin A      Revision number: 5
  SAFETY DATA SHEET

Section 1. IDENTIFICATION
  Product name:        Cyclosporin A

  Revision number:        5

Section 2. HAZARDS IDENTIFICATION
  GHS classification
  PHYSICAL HAZARDS        Not classified
  HEALTH HAZARDS
  Acute toxicity (Oral)        Category 4
    Category 1A
  Carcinogenicity
  Reproductive toxicity        Category 1B
  Reproductive toxicity (Effects on or via lactation) Additional category for effects on or via lactation
  ENVIRONMENTAL HAZARDS        Not classified
  GHS label elements, including precautionary statements
  Pictograms or hazard symbols
  Signal word        Danger
  Hazard statements        Harmful if swallowed
    May cause cancer
    May damage fertility or the unborn child
    May cause harm to breast-fed children
  Precautionary statements:
    Obtain special instructions before use.
  [Prevention]
    Do not handle until all safety precautions have been read and understood.
    Do not breathe dust/fume/gas/mist/vapours/spray.
    Avoid contact during pregnancy/while nursing.
    Do not eat, drink or smoke when using this product.
    Wash hands thoroughly after handling.
    Use personal protective equipment as required.
  [Response]        IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
    Rinse mouth.
    IF exposed or concerned: Get medical advice/attention.
  [Storage]        Store locked up.
  [Disposal]        Dispose of contents/container through a waste management company authorized by
    the local government.

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
    Substance
  Substance/mixture:
  Cyclosporin A

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
  Components:        Cyclosporin A
  Percent:        >97.0%(LC)(N)
  CAS Number:        59865-13-3
  Synonyms:        Cyclosporin
  Chemical Formula:        C62H111N11O12

Section 4. FIRST AID MEASURES
  Inhalation:        Remove victim to fresh air and keep at rest in a position comfortable for breathing.
    Get medical advice/attention.
  Skin contact:        Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
    soap and water. Get medical advice/attention.
  Eye contact:        Rinse cautiously with water for several minutes. Remove contact lenses, if present
    and easy to do. Get medical advice/attention.
  Ingestion:        Get medical advice/attention.Rinse mouth.
  Protection of first-aiders:        A rescuer should wear personal protective equipment, such as rubber gloves and air-
    tight goggles.

Section 5. FIRE-FIGHTING MEASURES
  Suitable extinguishing        Dry chemical, foam, water spray, carbon dioxide.
  media:
  Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
  from the chemical:        generate poisonous fume.
  Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
    method according to the surrounding situation is used. Uninvolved persons should
    evacuate to a safe place. In case of fire in the surroundings: Remove movable
    containers if safe to do so.
  Special protective        When extinguishing fire, be sure to wear personal protective equipment.
  equipment for firefighters:

Section 6. ACCIDENTAL RELEASE MEASURES
    Use extra personal protective equipment (P3 filter respirator for toxic particles). Keep
  Personal precautions,
  protective equipment and people away from and upwind of spill/leak. Entry to non-involved personnel should
  emergency procedures: be controlled around the leakage area by roping off, etc.
  Environmental precautions: Prevent product from entering drains.
  Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
  containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
  up: appropriate laws and regulations.

Section 7. HANDLING AND STORAGE
  Precautions for safe handling
  Technical measures:        Handling is performed in a well ventilated place. Wear suitable protective equipment.
    Prevent dispersion of dust. Wash hands and face thoroughly after handling.
    Use a closed system if possible. Use a local exhaust if dust or aerosol will be
    generated.
  Advice on safe handling: Avoid all contact!
  Conditions for safe storage, including any
  incompatibilities
  Storage conditions:        Keep container tightly closed. Store in a refrigerator.
    Store locked up.
    Store away from incompatible materials such as oxidizing agents.
    Heat-sensitive
    Comply with laws.
  Packaging material:

Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
  Engineering controls:        Install a closed system or local exhaust. Also install safety shower and eye bath.
  Cyclosporin A

Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
  Personal protective equipment
  Respiratory protection: Dust respirator, self-contained breathing apparatus(SCBA), supplied air respirator,
    etc. Use respirators approved under appropriate government standards and follow
    local and national regulations.
  Hand protection:        Impervious gloves.
    Safety goggles. A face-shield, if the situation requires.
  Eye protection:
  Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires.

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
  Physical state (20°C):        Solid
    Crystal- Powder
  Form:
  Colour:        White - Almost white
    No data available
  Odour:
  pH: No data available
  Melting point/freezing point:151°C
  Boiling point/range:        No data available
  Flash point:        No data available
  Flammability or explosive
  limits:
  Lower:        No data available
  Upper:        No data available
  Relative density:        No data available
  Solubility(ies):
  [Water]        No data available
  [Other solvents]
  Very soluble:        Methanol, Ether, Acetone, Ethanol
  Soluble:        Chloroform
  Log Pow:        2.92

Section 10. STABILITY AND REACTIVITY
  Chemical stability:        Stable under proper conditions.
  Possibility of hazardous No special reactivity has been reported.
  reactions:
  Incompatible materials: Oxidizing agents
  Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx)
  products:

Section 11. TOXICOLOGICAL INFORMATION
  Acute Toxicity:        orl-rat LD50:1480 mg/kg
    ipr-rat LD50:147 mg/kg
    scu-rat LD50:286 mg/kg
    ivn-rat LD50:24 mg/kg
  Skin corrosion/irritation: No data available
  Serious eye        No data available
  damage/irritation:
  Germ cell mutagenicity: sce-hmn-lym 1 mg/L
    oms-hmn-lym 50 mg/L
  Carcinogenicity:        orl-man TDLo:259 mg/kg/2W-C
  IARC =        Group 1 (Carcinogenic to humans)
  NTP =        a (Known to be carcinogens)
    No data available
  Reproductive toxicity:
  RTECS Number:        GZ4120000

Section 12. ECOLOGICAL INFORMATION
  Ecotoxicity:
  Fish:        No data available
  Crustacea:        No data available
  Cyclosporin A

Section 12. ECOLOGICAL INFORMATION
  Algae:        No data available
  Persistence / degradability: No data available
  Bioaccumulative        No data available
  potential(BCF):
  Mobility in soil
    2.92
  Log Pow:
  Soil adsorption (Koc):        No data available
    No data available
  Henry's Law
  constant(PaM3/mol):

Section 13. DISPOSAL CONSIDERATIONS
    Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
    with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
    Observe all federal, state and local regulations when disposing of the substance.

Section 14. TRANSPORT INFORMATION
    Does not correspond to the classification standard of the United Nations
  Hazards Class:
  UN-No:        Not listed

Section 15. REGULATORY INFORMATION
  Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
  and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
    loading and unloading were prescribed.

SECTION 16 - ADDITIONAL INFORMATION
N/A

环孢素分子结构与计算化学数据

计算化学数据

1、   疏水参数计算参考值（XlogP）：7.5
2、   氢键供体数量：5
3、   氢键受体数量：12
4、   可旋转化学键数量：15
5、   互变异构体数量：16
6、   拓扑分子极性表面积（TPSA）：279
7、   重原子数量：85
8、   表面电荷：0
9、   复杂度： 2330
10、同位素原子数量：0
11、确定原子立构中心数量：12
12、不确定原子立构中心数量：0
13、确定化学键立构中心数量：1
14、不确定化学键立构中心数量：0
15、共价键单元数量：1

环孢素下游产品

二氢环孢菌素A [(3R,14S)-5-(dimethylamino)-3,15-dimethyl-14-[[(2S)-4-methyl-2-(methylamino)pentanoyl]amino]-1,6,13-trioxohexadecan-4-yl] acetate

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环孢素

环孢素 制备方法及用途

制备方法

合成制备方法

用途简介

用途

环孢素 物化性质

环孢素 安全信息

环孢素 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

环孢素 MSDS

环孢素 分子结构与计算化学数据

计算化学数据

环孢素 下游产品

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环孢菌素A

湖北诺纳科技有限公司

环孢素 A

湖北云镁科技有限公司

环胞霉素A

湖北万得化工有限公司

环蒽孢A

湖北齐飞医药化工有限公司

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湖北信康医药化工有限公司

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环孢素 A

环孢素制备方法及用途

环孢素物化性质

环孢素安全信息

环孢素毒理性

环孢素分子结构与计算化学数据

环孢素下游产品