3-氟-4-甲氧基苯乙酮
- 中文名称：
- 3-氟-4-甲氧基苯乙酮
- 中文别名：
- 3-氟-4-甲氧基苯乙酮;
氟磷酸二异丙酯
- 英文名称：
- Phosphorofluoridicacid, bis(1-methylethyl) ester
- 英文别名：
- diisopropyl fluorophosphate;
Isofluorphate;
Dyflos;
Neoglaucit;
Isoflurophate;
Difluorophate;
isofluorophate;
P(O)F(OiPr)2;
Floropryl;
diisopropyl phosphorofluoridate;
Isoflurophosphate;
2-[fluoro(propan-2-yloxy)phosphoryl]oxypropane;
Fluostigmine;
diisopropyl phosphofluoridate
- CAS No.：
- 55-91-4
- 分 子 式：
- C6H14FO3P
- 分 子 量：
- 184.15
- 精确分子量：
- 184.06600
- PSA：
- 45.34000
- MDL：
- MFCD00008873
- EINECS：
- 200-247-6
- BRN：
- 1723307
- InChI：
- The Key: MUCZHBLJLSDCSD-UHFFFAOYSA-N3
- 风险术语：
- R36/37/38;
- 分子结构式：
-
- SDS：
- 查看
3-氟-4-甲氧基苯乙酮 制备方法及用途
制备方法
-
酶的抑制剂。医用胆碱功能剂。
用途简介
用途
酶的抑制剂。医用胆碱功能剂。
3-氟-4-甲氧基苯乙酮 物化性质
- 密度：
- 1.06 g/mL at 25 °C(lit.)
- 熔点：
- −82 °C(lit.)
- 沸点：
- 62 °C9 mm Hg(lit.)
- 闪点：
- 64.5ºC
- 折射率：
- n20/D 1.385(lit.)
- 存储条件/存储方法：
- 库房通风低温干燥,与食品原料分开储运
- 其它信息：
1. 性状： 无色液体。
2. 密度（g/mL,25/4℃）：1.055
3. 相对蒸汽密度（g/mL,空气=1）：未确定
4. 熔点（ºC）：82
5. 沸点（ºC,常压）：未确定
6. 沸点（ºC,5.2kPa）：（9毫米汞柱）62℃（1.200kPa）。
7. 折射率：1.3830
8. 闪点（ºC）： 未确定
9. 比旋光度（º）： 未确定
10. 自燃点或引燃温度（ºC）：未确定
11. 蒸气压（kPa,25ºC）：未确定
12. 饱和蒸气压（kPa,60ºC）：未确定
13. 燃烧热（KJ/mol）：未确定
14. 临界温度（ºC）：未确定
15. 临界压力（KPa）：未确定
16. 油水（辛醇/水）分配系数的对数值：未确定
17. 爆炸上限（%,V/V）：未确定
18. 爆炸下限（%,V/V）：未确定
19. 溶解性：25℃时在水中的溶解度（质量分数）1.54%（分解，pH值约2.5）。不易溶于矿物油。
3-氟-4-甲氧基苯乙酮 安全信息
- 包装等级：
- I
- 风险类别：
- 6.1(a)
- WGK_Germany：
- 3
德国有关水污染物质的分类清单 - 危险类别码：
- R26/27/28
- 安全说明：
- S36/37/39-S45
- RTECS号：
- TE5075000
- 安全标志：
- S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
: - 危险标志：
- T+,Xi
3-氟-4-甲氧基苯乙酮 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TE5075000
- CHEMICAL NAME :
- Phosphorofluoridic acid, bis(1-methylethyl) ester
- CAS REGISTRY NUMBER :
- 55-91-4
- BEILSTEIN REFERENCE NO. :
- 1723307
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 49
- MOLECULAR FORMULA :
- C6-H14-F-O3-P
- MOLECULAR WEIGHT :
- 184.17
- WISWESSER LINE NOTATION :
- 1Y1&OPO&FOY1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 8200 ug/m3/10M
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - headache
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 360 mg/m3/10M
- TOXIC EFFECTS :
- Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- JCSOA9 Journal of the Chemical Society. (London, UK) 1926-65. For publisher information, see JCPRB4. Volume(issue)/page/year: -,695,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1280 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,85,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1440 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 226,302,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year: 37,350,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 440 mg/m3/10M
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
- REFERENCE :
- NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 157,287,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 72 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,414,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2450 ug/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962- Volume(issue)/page/year: 23,769,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 34,603,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 15,169,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 239,126,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 3 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,414,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 3430 ug/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,414,1946
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 3 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,421,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DEGEA3 Deutsche Gesundheitswesen. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 15,2179,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 100 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 200 ug/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - fasciculations Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,421,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DEGEA3 Deutsche Gesundheitswesen. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 15,2179,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 1700 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,400,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 4 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,414,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,414,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 750 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Ocular
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1150 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,414,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 1450 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 124,212,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - domestic
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - domestic
- DOSE/DURATION :
- 800 ug/kg
- TOXIC EFFECTS :
- Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16800 ug/kg/8W-C
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 105,156,1952
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 14 mg/kg/14D-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Behavioral - alteration of operant conditioning Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- REFERENCE :
- TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 40,47,1988
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20 mg/kg/20D-I
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - recording from peripheral motor nerve
- REFERENCE :
- ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 58,97,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 13 mg/kg/13D-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 90,477,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5600 ug/kg/28D-I
- TOXIC EFFECTS :
- Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- REFERENCE :
- APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa, Switzerland) V.1-41, 1950-90. Volume(issue)/page/year: 31,575,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 5 mg/kg/8W-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Behavioral - ataxia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- REFERENCE :
- EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 2,383,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 4 mg/kg/4D-I
- TOXIC EFFECTS :
- Spinal Cord - other degenerative changes Peripheral Nerve and Sensation - structural change in nerve or sheath Behavioral - muscle weakness
- REFERENCE :
- ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 68,308,1994 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 6 mg/kg
- SEX/DURATION :
- female 6-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,S204,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 500 ug/kg
- SEX/DURATION :
- female 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 31,596,1972 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 3,289,1975 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW IRXPAT International Review of Experimental Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962- Volume(issue)/page/year: 3,219,1964 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,365,1973 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 1(1),93,1971 TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 48,225,1951 TOXICOLOGY REVIEW IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5. Volume(issue)/page/year: 19,535,1950 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - B0106 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 7 (estimated)
3-氟-4-甲氧基苯乙酮 MSDS
| 第一部分：化学品名称 |
| 化学品中文名称： | 氟磷酸异丙酯；氟磷酸二异丙酯 |
| 化学品英文名称： | Isopropyl fluorophosphate；Diisopropyl fluorophosphate |
| 中文俗名或商品名： | |
| Synonyms： | |
| CAS No.： | 55-91-4 |
| 分子式： | C6H14FO3P |
| 分子量： | 184.15 |
| 第二部分：成分/组成信息 |
| 纯化学品 混合物 | ||||||
| 化学品名称：氟磷酸异丙酯；氟磷酸二异丙酯 | ||||||
|
| 第三部分：危险性概述 |
| 危险性类别： | 第6；l类 毒害品 |
| 侵入途径： | 吸入 食入 经皮吸收 |
| 健康危害： | 胆碱酯酶抑制剂。吸入、摄入或经皮肤吸收后可能致死。中毒表现有咳嗽、胸痛、呼吸困难、头痛、恶心、呕吐、眩晕、腹泻、胃痛、惊厥。 |
| 环境危害： | |
| 燃爆危险： | 本品可燃，高毒 |
| 第四部分：急救措施 |
| 皮肤接触： | 脱去污染的衣着，用大量流动清水彻底冲洗。 |
| 眼睛接触： | 立即提起眼睑，用流动清水冲洗。 |
| 吸入： | 迅速脱离现场至空气新鲜处。注意保暖，保持呼吸道通畅。必要时进行人工呼吸。就医。 |
| 食入： | 患者清醒时给饮大量温水，催吐，就医。 |
| 第五部分：消防措施 |
| 危险特性： | 遇高热、明火或与氧化剂接触，有引起燃烧的危险。受高热分解放出有毒的气体。 |
| 有害燃烧产物： | 一氧化碳、氟化氢、氧化磷、磷烷。 |
| 灭火方法及灭火剂： | 雾状水、泡沫、二氧化碳、砂土。 |
| 消防员的个体防护： | 消防人员必须佩戴过滤式防毒面具(全面罩)或隔离式呼吸器、穿全身防火防毒服，在上风向灭火。 |
| 禁止使用的灭火剂： | |
| 闪点(℃)： | 无资料 |
| 自燃温度(℃)： | 无资料 |
| 爆炸下限[%(V/V)]： | 无资料 |
| 爆炸上限[%(V/V)]： | 无资料 |
| 最小点火能(mJ)： | |
| 爆燃点： | |
| 爆速： | |
| 最大燃爆压力(MPa)： | |
| 建规火险分级： |
| 第六部分：泄漏应急处理 |
| 应急处理： | 疏散泄漏污染区人员至安全区，禁止无关人员进入污染区，建议应急处理人员戴好防毒面具，穿化学防护服。不要直接接触泄漏物，在确保安全情况下堵漏。用沙土、干燥石灰或苏打灰混合，然后收集运至废物处理场所处置。如果大量泄漏，与有关技术部门联系，确定清除方法。 |
| 第七部分：操作处置与储存 |
| 操作注意事项： | 密闭操作，提供充分的局部排风。操作尽可能机械化、自动化。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴自吸过滤式防毒面具（全面罩），穿胶布防毒衣，戴橡胶耐油手套。远离火种、热源，工作场所严禁吸烟。使用防爆型的通风系统和设备。防止蒸气泄漏到工作场所空气中。避免与氧化剂、碱类接触。搬运时要轻装轻卸，防止包装及容器损坏。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。 |
| 储存注意事项： | 储存于阴凉、干燥、通风良好的库房。远离火种、热源。保持容器密封。应与氧化剂、碱类、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有泄漏应急处理设备和合适的收容材料。应严格执行极毒物品“五双”管理制度。 |
| 第八部分：接触控制/个体防护 |
| 最高容许浓度： | 中国MAC：未制定标准苏联MAC：未制定标准美国TWA：未制定标准美国STEL：未制定标 |
| 监测方法： | |
| 工程控制： | 严加密闭，提供充分的局部排风。尽可能机械化、自动化。 |
| 呼吸系统防护： | 可能接触其蒸气时，应该佩带防毒面具。紧急事态抢救或逃生时，佩带自给式呼吸器。 |
| 眼睛防护： | 戴化学安全防护眼镜。 |
| 身体防护： | 穿相应的防护服。 |
| 手防护： | 戴防化学品手套。 |
| 其他防护： | 工作现场禁止吸烟、进食和饮水。工作后，彻底清洗。工作服不要带到非作业场所，单独存放被毒物污染的衣服， |
| 第九部分：理化特性 |
| 外观与性状： | 无色油状液体，易潮解。 |
| pH： | |
| 熔点(℃)： | -82 |
| 沸点(℃)： | 183 |
| 相对密度(水=1)： | 1．07 |
| 相对蒸气密度(空气=1)： | 6．3 |
| 饱和蒸气压(kPa)： | 0．13／20℃ |
| 燃烧热(kJ/mol)： | |
| 临界温度(℃)： | |
| 临界压力(MPa)： | |
| 辛醇/水分配系数的对数值： | |
| 闪点(℃)： | 无资料 |
| 引燃温度(℃)： | 无资料 |
| 爆炸上限%(V/V)： | 无资料 |
| 爆炸下限%(V/V)： | 无资料 |
| 分子式： | C6H14FO3P |
| 分子量： | 184.15 |
| 蒸发速率： | |
| 粘性： | |
| 溶解性： | 微溶于水，溶于醇、醚、氯仿。 |
| 主要用途： | 用于医药。 |
| 第十部分：稳定性和反应活性 |
| 稳定性： | 在常温常压下 稳定 |
| 禁配物： | 强氧化剂、强碱。 |
| 避免接触的条件： | 接触潮湿空气。 |
| 聚合危害： | 不能出现 |
| 分解产物： | 一氧化碳、氟化氢、氧化磷、磷烷。 |
| 第十一部分：毒理学资料 |
| 急性毒性： | 属高毒类 LD50：5mg／kg(大鼠经口)；72mg／kg(小鼠经皮) LC50：360mg／m3 10分钟(大鼠吸入) |
| 急性中毒： | |
| 慢性中毒： | |
| 亚急性和慢性毒性： | |
| 刺激性： | |
| 致敏性： | |
| 致突变性： | |
| 致畸性： | |
| 致癌性： |
| 第十二部分：生态学资料 |
| 生态毒理毒性： | |
| 生物降解性： | |
| 非生物降解性： | |
| 生物富集或生物积累性： |
| 第十三部分：废弃处置 |
| 废弃物性质： | |
| 废弃处置方法： | 处置前应参阅国家和地方有关法规。建议用焚烧法处置。焚烧炉排出的气体要通过洗涤器除去。 |
| 废弃注意事项： |
| 第十四部分：运输信息 |
|
|
| 危险货物编号： | 61114 |
| UN编号： | |
| 包装标志： | |
| 包装类别： | Ⅰ |
| 包装方法： | 螺纹口玻璃瓶、铁盖压口玻璃瓶、塑料瓶或金属桶（罐）外普通木箱。 |
| 运输注意事项： | 铁路运输时应严格按照铁道部《危险货物运输规则》中的危险货物配装表进行配装。运输前应先检查包装容器是否完整、密封，运输过程中要确保容器不泄漏、不倒塌、不坠落、不损坏。严禁与酸类、氧化剂、食品及食品添加剂混运。运输时运输车辆应配备相应品种和数量的消防器材及泄漏应急处理设备。运输途中应防曝晒、雨淋，防高温。公路运输时要按规定路线行驶，勿在居民区和人口稠密区停留。 |
| RETCS号： | |
| IMDG规则页码： |
| 第十五部分：法规信息 |
| 国内化学品安全管理法规： | 化学危险物品安全管理条例 (1987年2月17日国务院发布)，化学危险物品安全管理条例实施细则 (化劳发[1992] 677号)，工作场所安全使用化学品规定 ([1996]劳部发423号)等法规，针对化学危险品的安全使用、生产、储存、运输、装卸等方面均作了相应规定；常用危险化学品的分类及标志 (GB 13690-92)将该物质划为第6.1 类毒害品；剧毒物品分级、分类与品名编号(GA 57-93)中，该物质属第二类 A级有机剧毒品。 |
| 国际化学品安全管理法规： |
| 第十六部分：其他信息 |
| 参考文献： | 1.周国泰，化学危险品安全技术全书，化学工业出版社，1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编，化学品毒性法规环境数据手册，中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989 |
| 填表时间： | 年月日 |
| 填表部门： | |
| 数据审核单位： | |
| 修改说明： | |
| 其他信息： | 2 |
| MSDS修改日期： | 年月日 |
3-氟-4-甲氧基苯乙酮 分子结构与计算化学数据
分子结构数据
五、分子性质数据：
1、 摩尔折射率：40.29
2、 摩尔体积（m3/mol）：170.6
3、 等张比容（90.2K）：386.5
4、 表面张力（dyne/cm）：26.3
5、 极化率（10
计算化学数据
1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:0
3.氢键受体数量:4
4.可旋转化学键数量:4
5.互变异构体数量:无
6.拓扑分子极性表面积35.5
7.重原子数量:11
8.表面电荷:0
9.复杂度:144
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
