(±)-4-甲氧基-N-[2-[2-(1-甲基-2-哌啶基)乙基]苯基]苯甲酰胺
- 中文名称：
- (±)-4-甲氧基-N-[2-[2-(1-甲基-2-哌啶基)乙基]苯基]苯甲酰胺
- 中文别名：
- (±)-4-甲氧基-N-[2-[2-(1-甲基-2-哌啶基)乙基]苯基]苯甲酰胺;
4-甲氧基-N-(2-(2-(1-甲基哌啶-2-基)乙基)苯基)苯甲酰胺
- 英文名称：
- Benzamide,4-methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-
- 英文别名：
- encainide;
MJ-9067[AS BASE];
MJ-9067;
Enkaid;
Encainida [spanish];
M-9067-1;
4-methoxy-N-<2-<2-(1-methyl-2-piperidinyl)ethyl>phenyl>benzamide;
Encainide [french];
Encainidum;
Enkade;
[14C]-Encainide;
Encainida;
(-)-Encainide;
BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-;
4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide
- CAS No.：
- 66778-36-7
- 分 子 式：
-
C22H28N2O2
- 分 子 量：
- 352.47
- 精确分子量：
- 352.21500
- PSA：
- 41.57000
- InChI：
- The Key: PJWPNDMDCLXCOM-UHFFFAOYSA-N3
- 分子结构式：
-
- SDS：
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(±)-4-甲氧基-N-[2-[2-(1-甲基-2-哌啶基)乙基]苯基]苯甲酰胺 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CV5521000
- CHEMICAL NAME :
- Benzamide,
4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)pheny
l)-, (+-)-
- CAS REGISTRY NUMBER :
- 66778-36-7
- BEILSTEIN REFERENCE NO. :
- 0497572
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C22-H28-N2-O2
- MOLECULAR WEIGHT :
- 352.52
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - infant
- DOSE/DURATION :
- 3289 ug/kg
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction)
Cardiac - change in rate
- REFERENCE :
- AEMED3 Annals of Emergency Medicine. (American College of Emergency
Physicians, 1125 Executive Circle, Irving, TX 75038)
Volume(issue)/page/year: 21,998,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 43 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Cardiac - pulse rate increase, without fall in BP
Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- AJCDAG American Journal of Cardiology. (Technical Pub. Co., 875 Third Ave.,
New York, NY 10022) V.1- 1958- Volume(issue)/page/year: 57,878,1986
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 3214 mg/kg/19H
- TOXIC EFFECTS :
- Cardiac - cardiomyopathy including infarction
Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year:
102,857,1981
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 2400 ug/kg/17H
- TOXIC EFFECTS :
- Cardiac - cardiomyopathy including infarction
Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year:
102,857,1981
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 1500 ug/kg
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year:
102,857,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 38100 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 281,277,1986
