醋丁洛尔
- 中文名称：
- 醋丁洛尔
- 中文别名：
- 醋丁洛尔;
醋丁酰心安;
N-[3-乙酰基-4-(2-羟基-3-异丙基氨基丙氧基)苯基]丁酰胺
- 英文名称：
- Butanamide,N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-
- 英文别名：
- acebutolol;
N-(3-Acetyl-4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)butyramide;
Acebutolol
- CAS No.：
- 37517-30-9
- 分 子 式：
-
C18H28N2O4
- 分 子 量：
- 336.43
- 精确分子量：
- 336.20500
- PSA：
- 87.66000
- EINECS：
- 253-539-0
- InChI：
- The Key: GOEMGAFJFRBGGG-UHFFFAOYSA-N3
- 分子结构式：
-
- SDS：
- 查看
醋丁洛尔 物化性质
- 外观与性状：
- 晶体
- 密度：
- 1.118g/cm3
- 熔点：
- 119-123ºC
- 沸点：
- 564.1ºC at 760 mmHg
- 闪点：
- 295ºC
- 折射率：
- 1.542
- 存储条件/存储方法：
- 库房通风低温干燥
醋丁洛尔 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EJ3500500
- CHEMICAL NAME :
- Butanamide,
N-(3-acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)prop
oxy)phenyl)-, (+-)-
- CAS REGISTRY NUMBER :
- 37517-30-9
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C18-H28-N2-O4
- MOLECULAR WEIGHT :
- 336.48
- WISWESSER LINE NOTATION :
- 3VMR CV1 DO1YQ1MY1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 152 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in conduction velocity
Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year:
20,69,1983
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 137 mg/kg/24D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
- REFERENCE :
- AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
111,533,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 109 mg/kg/22D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
- REFERENCE :
- AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
111,533,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku,
Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952-
Volume(issue)/page/year: 42,82,1993
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 75200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NPMDAD Nouvelle Presse Medicale. (Paris, France) V.1-11, 1972-82.
Volume(issue)/page/year: 7,3258,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 4 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in rate
Vascular - BP lowering not characterized in autonomic section
Kidney, Ureter, Bladder - changes in blood vessels or in circulation of
kidney
- REFERENCE :
- MASODV Masui to Sosei. Anesthesia and Resuscitation. (Hiroshima Masui
Igakkai, Hiroshima Daigaku Igakubu Masuigaku Kyoshitsu, 1-2-3 Kasumi,
Minami-ku, Hiroshima, Hiroshima, Japan) V.6- 1970-
Volume(issue)/page/year: 16,13,1980
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 120 mg/kg
- SEX/DURATION :
- female 34-39 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Specific Developmental Abnormalities - respiratory system
- REFERENCE :
- DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc.,
79 Fifth Ave., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
4(Suppl 1),109,1982
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 1080 mg/kg
- SEX/DURATION :
- female 1-39 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - biochemical and metabolic
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
283,1077,1981
醋丁洛尔 海关数据
中国海关编码：2924299090
- 概述：
- 2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
- 申报要素：
- 品名, 成分含量, 用途, 包装
- 摘要/Summary：
- 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
推荐供应商
上海启太生物科技有限公司
醋丁洛尔杂质
- 联系人：肖经理
- 电 话：176-21686100
- 手 机：17621686100
- Cas号：37517-30-9
- 包装：25mg支
- 纯度：95%
- 价格：洽谈
湖北恩星生物科技有限公司
醋丁洛尔
- 联系人：邵经理
- 电 话：16621771607
- 手 机：16621771607
- Cas号：37517-30-9
- 包装：100kg,200kg,300kg,400kg,500kg
- 纯度：
- 价格：64.0元 - 100.0元
湖北弘景化工有限公司
醋丁洛尔
- 联系人：王先生
- 电 话：027-82333386
- 手 机：13669024603
- Cas号：37517-30-9
- 包装：洽谈
- 纯度：
- 价格：洽谈
