米诺环素
- 中文名称：
- 米诺环素
- 中文别名：
- 米诺环素;
4,7-双(二甲氨基)-1,4,4a,5,5a,6,11,12a-八氢-3,10,12,12a-四羟基-1,11-二氧-2-并四苯甲酰胺;
二甲胺四环素;
7-二甲胺基-6-去甲基-6-去氧四环素
- 英文名称：
- Minocycline
- 英文别名：
- minocycline;
Apo-Minocycline;
Arestin;
Minocycline;
7-(N,N-dimethylamino)sancycline;
7-dimethylamino-6-demethyl-6-deoxytetracycline;
Minociclina;
Minocyclin;
Minocin;
Dynacin;
4S-(4a,4aa,5aa,12aa)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacene carboxamide;
Aknemin;
Minocyclinum [INN-Latin];
(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;
Minocyclinum
- CAS No.：
- 10118-90-8
- 分 子 式：
-
C23H27N3O7
- 分 子 量：
- 457.48
- 精确分子量：
- 457.18500
- PSA：
- 164.63000
- EINECS：
- 237-099-7
- InChI：
- InChI=1/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s13
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
-
- 分子结构式：
-
- SDS：
- 查看
米诺环素 物化性质
- 外观与性状：
- 亮黄色-橙色非晶形的固体
- 密度：
- 1.553 g/cm3
- 沸点：
- 659.401ºC at 760 mmHg
- 闪点：
- 352.593ºC
- 折射率：
- 1.717
米诺环素 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QI7630000
- CHEMICAL NAME :
- 2-Naphthacenecarboxamide,
4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro
-3,10,12,12a- tetrahydroxy-1,11-dioxo-
- CAS REGISTRY NUMBER :
- 10118-90-8
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C23-H27-N3-O7
- MOLECULAR WEIGHT :
- 457.53
- WISWESSER LINE NOTATION :
- L E6 C666 BV FV CU GUTTT&J DQ EQ GMVH HQ IN1&1 ON1&1
RQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 28 mg/kg/2W-I
- TOXIC EFFECTS :
- Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.)
Sense Organs and Special Senses (Eye) - visual field changes
Behavioral - headache
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 343 mg/kg/17W-I
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), diffuse
Liver - liver function tests impaired
Blood - eosinophilia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 112 mg/kg/4W-I
- TOXIC EFFECTS :
- Liver - liver function tests impaired
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - body temperature increase
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - interstitial nephritis
Kidney, Ureter, Bladder - proteinuria
Kidney, Ureter, Bladder - hematuria
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 1204 mg/kg/86W-I
- TOXIC EFFECTS :
- Musculoskeletal - joints
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 730 mg/kg/1Y-I
- TOXIC EFFECTS :
- Behavioral - anorexia (human)
Gastrointestinal - nausea or vomiting
Liver - liver function tests impaired
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 310 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 38 mg/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions
Behavioral - excitement
Musculoskeletal - changes in teeth and supporting structures
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 3750 ug/L
- REFERENCE :
- BCPHBM British Journal of Clinical Pharmacology. (Blackwell Scientific Pub.
Ltd., POB 88, Oxford, UK) V.1- 1974- Volume(issue)/page/year:
16,127,1983
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3732
No. of Facilities: 13 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 7704 (estimated)
No. of Female Employees: 7190 (estimated)
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- Cas号：10118-90-8
- 包装：1kg
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- 联系人：国内业务部
- 电 话：0571-86960380
- 手 机：
- Cas号：10118-90-8
- 包装：洽谈
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