硝酸铅,10099-74-8，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

结构与计算化学

表征图谱

硝酸铅

中文名称：: 硝酸铅

中文别名：: 硝酸铅;
硝酸鉛

英文名称：: Lead dinitrate

英文别名：: lead nitrate;
PB(NO3)2;
LeadNitrateAcs;
LeadNitrateAr;
LEAD STANDARD;
Lead(II)nitrate;
plumbousnitrate;
leaddinitrate;
Lead(II) nitrate;
Lead nitrate;
LeadNitrateGr;
nitratedeplomb;
LEAD(+2)NITRATE;
Lead(II) Nitrate;
Enriched Isotope 207Pb Spike;
LEAD NITRATE;
Lead dinitrate

CAS No.：: 10099-74-8

分子式：: N₂O₆Pb

分子量：: 331.21

精确分子量：: 331.95200

PSA：: 137.76000

MDL：: MFCD00011153

EINECS：: 233-245-9

InChI：: InChI=1/2HNO3.Pb/c2*2-1(3)4;/h2*(H,2,3,4);3

危险品标志：: TN

风险术语：: R20/22;R33;R50/53

安全术语：: S45;S53;S60

分子结构式：

SDS：: 查看

硝酸铅制备方法及用途

制备方法

1.盐析法将金属铅放人熔铅炉中熔化后，水激成铅花或制成铅皮，再卷成铅卷。将铅卷(或铅花)放人耐酸反应器中，加入约20%稀硝酸，在稍过量铅的情况下进行反应，至反应液呈淡黄色，溶液浓度约40°Bé为止。澄清后趁热过滤，除去杂质。清液送入盐析器，边搅拌边加人浓硝酸，即有硝酸铅析出，搅拌1～2h后静置，使硝酸铅结晶下沉，经离心分离，制得硝酸铅成品。其反应方程式如下： 2.蒸发法按盐析法生产过程中得到的硝酸铅溶液，趁热过滤除去杂质，加入硝酸酸化至草绿色，送人蒸发器在常压进行浓缩至59.7°Bé，即有硝酸铅结晶析出，经离心分离，制得硝酸铅成品。其反应方程式如下：反应过程中有氧化氮气体逸出，有毒，处理方法参见硝酸钠生产的吸收法。3.用80kg洁净的蒸馏水在搅拌、加热条件下溶解60kg工业硝酸铅，待溶液沸腾后加入投料量0.5%的化学纯氨水，待氢氧化铁沉淀生成后，趁热过滤，滤液冷却结晶，过滤，离心甩干，即得试剂硝酸铅。一次结晶不合格，可再行重结晶处理。4.将颗粒状铅溶解于密度为1.40的硝酸中（1kg铅用1250ml硝酸），按反应的速度调节反应温度：待反应结束后，冷却，硝酸铅即以细小的结晶粉末析出，然后用浓硝酸洗涤，抽滤后按方法3提纯。若采用高纯度铅、硝酸和电导水，可制得高纯硝酸铅。

合成制备方法

2.蒸发法按盐析法生产过程中得到的硝酸铅溶液，趁热过滤除去杂质，加入硝酸酸化至草绿色，送人蒸发器在常压进行浓缩至59.7°Bé，即有硝酸铅结晶析出，经离心分离，制得硝酸铅成品。其反应方程式如下：

反应过程中有氧化氮气体逸出，有毒，处理方法参见硝酸钠生产的吸收法。

3.用80kg洁净的蒸馏水在搅拌、加热条件下溶解60kg工业硝酸铅，待溶液沸腾后加入投料量0.5%的化学纯氨水，待氢氧化铁沉淀生成后，趁热过滤，滤液冷却结晶，过滤，离心甩干，即得试剂硝酸铅。一次结晶不合格，可再行重结晶处理。

4.将颗粒状铅溶解于密度为1.40的硝酸中（1kg铅用1250ml硝酸），按反应的速度调节反应温度：

待反应结束后，冷却，硝酸铅即以细小的结晶粉末析出，然后用浓硝酸洗涤，抽滤后按方法3提纯。若采用高纯度铅、硝酸和电导水，可制得高纯硝酸铅。

用途简介

用作玻璃和搪瓷用的奶黄色素原料、纸张的黄色素原料。无机工业用于制造其他铅盐。医药工业用于制造收敛剂。用作相片增感剂。作矿石浮选剂。还用于制造火柴、烟火、炸药的氧化剂。用于镀铬电解液中作为添加剂，也可用作铝合金化学抛光的添加剂。用作分析试剂，氧化剂、照相增感剂。用于铅盐、烟花等的制造，用作媒染剂。

用途

1.用作玻璃和搪瓷用的奶黄色素原料、纸张的黄色素原料。无机工业用于制造其他铅盐。医药工业用于制造收敛剂。

2.用作相片增感剂。作矿石浮选剂。还用于制造火柴、烟火、炸药的氧化剂。

3.用于镀铬电解液中作为添加剂，也可用作铝合金化学抛光的添加剂。

4.用作分析试剂，氧化剂、照相增感剂。

5.用于铅盐、烟花等的制造，用作媒染剂。^[18]

硝酸铅毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OG2100000

CAS REGISTRY NUMBER :: 10099-74-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 64

MOLECULAR FORMULA :: N2-O6.Pb

MOLECULAR WEIGHT :: 331.21

WISWESSER LINE NOTATION :: PB N-O3*2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 93 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3613 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 74 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg/60D-I

TOXIC EFFECTS :: Blood - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 gm/kg/7D-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 97 mg/kg/27D-C

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 43 mg/kg/12W-C

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 13 gm/kg

SEX/DURATION :: male 6 week(s) pre-mating female 6 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 27 gm/kg

SEX/DURATION :: male 6 week(s) pre-mating female 6 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 43 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 36 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating female 10 day(s) pre-mating - 16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 50 mg/kg

SEX/DURATION :: female 3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 7993 ug/kg

SEX/DURATION :: female 17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 25 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 39964 ug/kg

SEX/DURATION :: female 17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 25 mg/kg

SEX/DURATION :: female 15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 25 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratesticular

DOSE :: 6624 ug/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 6624 ug/kg

SEX/DURATION :: male 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 100 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 25 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 50 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 50 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 50 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 23,143,1994 *** REVIEWS *** ACGIH TLV-TWA 0.05 mg(Pb)/m3; animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 23,325,1980 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Pb,254,1972 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.05 mg(Pb)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL-AUSTRIA:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-BELGIUM:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL-DENMARK:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-FINLAND:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-FRANCE:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL-GERMANY:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-HUNGARY:STEL 0.04 mg(Pb)/m3;Carcinogen JAN 1993 OEL-THE PHILIPPINES:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL-RUSSIA:STEL 0.005 ppm (0.01 mg(Pb)/m3) JAN 1993 OEL-SWEDEN:TWA 0.05 mg(Pb)/m3 (resp. dust) JAN 1993 OEL-SWEDEN:TWA 0.1 mg(Pb)/m3 (total dust) JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-THAILAND:TWA 0.2 mg(Pb)/m3 JAN 1993 OEL-TURKEY:TWA 0.2 mg(Pb)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO LEAD, INORGANIC-air:10H TWA <0.1 mg(Pb)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84473 No. of Facilities: 112 (estimated) No. of Industries: 4 No. of Occupations: 5 No. of Employees: 420 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84473 No. of Facilities: 450 (estimated) No. of Industries: 18 No. of Occupations: 20 No. of Employees: 11440 (estimated) No. of Female Employees: 4246 (estimated)

毒理学数据：

1.急性毒性^[5] LD50：93mg/kg（大鼠静脉）；74mg/kg（小鼠腹腔）

2.刺激性 暂无资料

3.亚急性与慢性毒性^[6] 实验动物给予硝酸铅可见神经组织明显损伤；血液系统损害。

4.致突变性^[7] 吞噬抑制能力：大肠杆菌320μmol/L。体细胞突变：小鼠淋巴细胞450mg/L。

5.致畸性^[8] 雌性仓鼠孕后8d静脉内给药最低中毒剂量50mg/kg，导致心血管系统、中枢神经系统、泌尿生殖系统发育畸形。

6.致癌性^[9] IARC致癌性评论：IARC将铅的无机化合物列为G2A，可能人类致癌物。

7.其他^[10] 大鼠静脉注射最低中毒剂量（TDLo）：25mg/kg（孕9d），对胚胎外结构（如胎盘、脐带）有影响，体壁发育异常，骨骼肌肉发育异常。小鼠皮下注射最低中毒剂量（TDLo）：6624μg/kg（30d，雄），致睾丸、附睾和输精管影响。

生态数据：

1.生态毒性 暂无资料

2.生物降解性 暂无资料

3.非生物降解性 暂无资料

4.其他有害作用^[11] 该物质对环境有危害，应特别注意对水体的污染；铅元素在生物体内有很强的蓄积作用。

硝酸铅

硝酸铅制备方法及用途

制备方法

合成制备方法

用途简介

用途

硝酸铅物化性质

硝酸铅安全信息

硝酸铅毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

硝酸铅 MSDS

硝酸铅分子结构与计算化学数据

计算化学数据

硝酸铅表征图谱

推荐供应商

硝酸铅

硝酸铅 制备方法及用途

制备方法

合成制备方法

用途简介

用途

硝酸铅 物化性质

硝酸铅 安全信息

硝酸铅 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

硝酸铅 MSDS

硝酸铅 分子结构与计算化学数据

计算化学数据

硝酸铅 表征图谱

推荐供应商

硝酸铅制备方法及用途

硝酸铅物化性质

硝酸铅安全信息

硝酸铅毒理性

硝酸铅分子结构与计算化学数据

硝酸铅表征图谱