硫酸软骨素,9007-28-7，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

毒理性

结构与计算化学

硫酸软骨素

中文名称：: 硫酸软骨素

中文别名：: 硫酸软骨素;
鲨鱼软骨素;
硫酸骨胶盐

英文名称：: chondroitin sulfate

英文别名：: (5ξ)-2-(Carboxyamino)-2-deoxy-3-O-β-D-glucopyranuronosyl-4-O-sulf o-α-L-arabino-hexopyranose;
chondroitin-4-sulfate;
Cholyltaurine;
2-[(R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-hexadecahydrocyclopenta[a]phenanthren-17-yl)pentanoylamino]ethanesulfonic acid;
[14C]-Taurocholic acid;
chonodroitinsufuric acid

CAS No.：: 9007-28-7

分子式：: (C₁₄H₂₁NO₁₄S)_n

分子量：: 479.36800

精确分子量：: 479.05800

PSA：: 287.45000

EINECS：: 232-696-9

InChI：: InChI=1/C14H23NO15S.Na/c1-3(17)15-5-10(9(30-31(24,25)26)4(2-16)27-13(5)23)28-14-8(20)6(18)7(19)11(29-14)12(21)22;/h4-11,13-14,16,18-20,23H,2H2,1H3,(H,15,17)(H,21,22)(H,24,25,26);/q;+1/p-1/t4-,5-,6-,7-,8+,9+,10-,11?,13-,14+;/m1./s13

危险品标志：

风险术语：

安全术语：

分子结构式：

SDS：: 查看

硫酸软骨素制备方法及用途

制备方法

提取、酶解、沉淀、干燥称取猪喉、鼻软骨投入5倍量的20g/L (2%)氢氧化钠溶液中浸泡,间歇搅拌,待浸出液达到5.5°Be时,过滤,滤渣再提取1次,合并滤液。在50℃用粗制胰酶水解,除去蛋白质等杂质,过滤至澄明,调pH6,加乙醇使醇含量达75%,静置过夜。离心分离,沉淀用无水乙醇洗涤,于60℃干燥,得硫酸软骨素粗品。猪喉、鼻软骨[20g/L NaOH]→提取液[胰酶]→ 酶解液 →[pH6]粗制品分级分离取粗品1kg加入蒸馏水20L,乙酸1L和氯化钙500g(以无水计)的混合液中,搅拌至全溶,再加乙醇的体积分数达50%,有沉淀析出,静置过夜。离心,收集钙盐沉淀物。再溶于蒸馏水40L,乙酸1.5L和氯化钙100g(以无水计)的混合液中,搅拌溶解,加入乙醇的体积分数为29%,沉淀析出,离心分离(沉淀回收CSA-Ca)。上清乙醇液中,继续加入适量乙醇,搅拌使其产生白色永久性混浊,静置过夜。次日,再加适量乙醇使其浓度达39%,放置沉淀结晶7d。离心,沉淀用无水乙醇洗涤,60℃干燥,得CSA-Ca。上清乙醇液回收CSA-Ca。粗制品[水,HAc, CaCl2, 乙醇]→CSA-Ca转型、沉淀、干燥取CSA-Ca纯品加适量蒸馏水溶解,调pH7,经强酸性苯乙烯阳离子交换树脂001×7吸附,收集流出液,加入溶液体积5g/L (0.5%)的氯化钠,用乙醇沉淀,静置过夜。离心,沉淀用无水乙醇洗涤2次,置60℃干燥,得硫酸软骨素A钠纯品。总收率对猪喉、鼻软骨计算为5%。CSA-Ca[001×7树脂(Na型)→[pH7]流出液(CSA-Na)[NaCl, 乙醇]→沉淀物 →CSA-Na纯品。

用途简介

主要应用于关节炎、滴眼液等，具有止痛，促进软骨再生的功效，对改善老年退行性关节炎、风湿性关节炎有一定的效果，可以改善关节问题。

硫酸软骨素毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GA8430000

CHEMICAL NAME :: Chondroitin sulfuric acids

CAS REGISTRY NUMBER :: 9007-28-7

LAST UPDATED :: 199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 6,506,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 455 gm/kg/26W-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 6,478,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1680 mg/kg/14D-I

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 14,3371,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3876 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 19 (estimated) No. of Female Employees: 19 (estimated)