制备方法

本品是山梨醇的脱水衍生物，为一口服渗透性脱水利尿药，作用机制类似于静注甘露醇和山梨醇。通过提高血浆渗透压，导致组织内(包括眼、脑、脑脊液等)水分进入血管内，从而减轻组织水肿，降低眼内压、颅内压和脑脊液容量及其压力。可用作医药中间体,合成塑料树脂添加剂,饲料添加剂。

用途简介

用途

1、有机化工中间体,异山梨醇因其特殊的手性特征,作为有机中间体,应用于新型高分子材料的合成,广泛用于电子工业,国防等领域。
2、医药中间体,异山梨醇大量应用于冠心病特效药硝基异山梨醇酯(消心痛)和其他成品药。
3、药品。

海关代码：

2932999099

WGK_Germany：

2
德国有关水污染物质的分类清单

危险类别码：

R22

安全说明：

S24/25

RTECS号：

LZ4380000

安全标志：

S24/25:防止皮肤和眼睛接触。

CHEMICAL IDENTIFICATION

RTECS NUMBER :

LZ4380000

CAS REGISTRY NUMBER :

652-67-5

BEILSTEIN REFERENCE NO. :

0080510

LAST UPDATED :

199612

DATA ITEMS CITED :

6

MOLECULAR FORMULA :

C6-H10-O4

MOLECULAR WEIGHT :

146.16

WISWESSER LINE NOTATION :

L44TJ BQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

24150 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,15,1969

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

11 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64(4),158S,1968

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

289 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,187,1969

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

13600 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,71,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

6870 mg/kg

TOXIC EFFECTS :

Brain and Coverings - changes in cerebral spinal fluid

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,15,1969

毒理学数据：

1、急性毒性：大鼠（口服）LD50： 24,150 mg/kg