硝呋噻唑
- 中文名称:
- 硝呋噻唑
- 中文别名:
- 硝呋噻唑
- 英文名称:
- Formic acid,2-[4-(5-nitro-2-furanyl)-2-thiazolyl]hydrazide
- 英文别名:
- N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide;
Nifurthiazole [USAN:INN];
NIFURTHIAZOLE;
Nifurthiazol;
formic acid N'-[4-(5-nitro-furan-2-yl)-thiazol-2-yl]-hydrazide;
2-<2-Formylhydrazino>-4-<5-nitro-2-furyl>-thiazol;
Nifurtiazol [INN-Spanish];
2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole;
Nifurthiazolum [INN-Latin];
Nefurthiazole
- CAS No.:
- 3570-75-0
- 分 子 式:
-
C8H6N4O4S
- 分 子 量:
- 254.24
- 精确分子量:
- 254.01100
- PSA:
- 141.22000
- InChI:
- The Key: DUWYZHLZDVCZIO-UHFFFAOYSA-N3
- 安全术语:
- Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.
- 分子结构式:
-
- SDS:
- 查看
硝呋噻唑 物化性质
- 密度:
- 1.612g/cm3
- 熔点:
- 215.5ºC (DECOMP)
- 沸点:
- 454.8ºC at 760mmHg
- 闪点:
- 228.9ºC
- 折射率:
- 1.679
硝呋噻唑 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LQ9275000
- CHEMICAL NAME :
- Formic acid,
2-(4-(5-nitro-2-furyl)-2-thiazolyl)hydrazide
- CAS REGISTRY NUMBER :
- 3570-75-0
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 26
- MOLECULAR FORMULA :
- C8-H6-N4-O4-S
- MOLECULAR WEIGHT :
- 254.24
- WISWESSER LINE NOTATION :
- T5OJ BNW E- ET5N CSJ BMMVH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1400 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 445 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10500 mg/kg/3W-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10500 mg/kg/3W-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 31 gm/kg/44W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30 gm/kg/33W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Blood - leukemia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 22 gm/kg/48W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 48 gm/kg/29W
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Blood - leukemia
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 28 gm/kg/33W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Blood - leukemia
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 41 gm/kg/49W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - Kidney tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 28 gm/kg/46W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
Skin and Appendages - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 38640 mg/kg/46W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 1575 mg/kg/5D (Intermittent)
- REFERENCE :
- CMMUAO Chemical Mutagens. Principles and Methods for Their Detection.
(Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1971-
Volume(issue)/page/year: 5,257,1978
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 7,151,1974
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 7,151,1974
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971
TOXICOLOGY REVIEW
CCSUDL Carcinogenesis--A Comprehensive Survey. (Raven Press, 1185 Ave. of
the Americas, New York, NY 10036) V.1- 1976- Volume(issue)/page/year:
4,171,1978
硝呋噻唑 海关数据
中国海关编码:2934100090
- 概述:
- 2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素:
- 品名, 成分含量, 用途
- 摘要/Summary:
- 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
硝呋噻唑 分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值(XlogP):1.7
2.氢键供体数量:2
3.氢键受体数量:7
4.可旋转化学键数量:3
5.互变异构体数量:4
6.拓扑分子极性表面积:141
7.重原子数量:17
8.表面电荷:0
9.复杂度:300
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1