N-乙酰对氨基酚,103-90-2，生产厂家，价格-洛克化工网移动版

返回



基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

结构与计算化学

下游产品

表征图谱

N-乙酰对氨基酚

中文名称：: N-乙酰对氨基酚

中文别名：: N-乙酰对氨基酚;
N-(4-羟基苯基)乙酰胺;
对乙酰氨基酚,N-(4-羟基苯基)乙酰胺,对羟基乙酰苯胺;
4'-羟基乙酰苯胺;
扑热息痛;
4-乙酰氨基酚;
4-乙酰胺基苯酚;
对乙酰氨基苯酚;
对乙酰氨基酚

英文名称：: 4-acetaminophenol

英文别名：: paracetamol;
Korum;
Fevor;
APAP;
4-Acetamidophenol;
Paracetamol;
N-(4-Hydroxyphenyl)acetamide;
Acetaminophen;
Dirox;
4'-Hydroxyacetanilide;
Dypap;
Exdol;
G 1;
Panex;
Hedex;
NAPAP

CAS No.：: 103-90-2

分子式：: C₈H₉NO₂

分子量：: 151.16

精确分子量：: 151.06300

PSA：: 49.33000

MDL：: MFCD00002328

EINECS：: 203-157-5

BRN：: 2208089

InChI：: InChI=1/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)/i2D,3D,4D,5D3

危险品标志：: Xn;

风险术语：: R22;R52/53

安全术语：: S61

分子结构式：

SDS：: 查看

N-乙酰对氨基酚制备方法及用途

制备方法

对氨基酚乙酰化而得。方法1:将对氨基酚加入稀乙酸中,再加入冰醋酸,升温至150℃反应7h,加入乙酐,再反应2h,检查终点,合格后冷却至25℃以下,甩滤,水洗至无乙酸味,甩干,得粗品。方法2:将对氨基酚、冰醋酸及含酸50%以上的酸母液一起蒸馏,蒸出稀酸的速度为每小时馏出总量的十分之一,待内温升至130℃以上,取样检查对氨基酚残留量低于2.5%,加入稀酸(含量50%以上),冷却结晶。甩滤,先用少量稀酸洗涤,再用大量水洗至滤液接近无色,得粗品。方法1的收率为90%,方法2的收率为90-95%。精制方法:将水加热至近沸时投入粗品。升温至全溶,加入用水浸泡过的活性炭,用稀乙酸调节至pH=4.2-4.6,沸腾10min。压滤,滤液加少量重亚硫酸钠。冷却至20℃以下,析出结晶。甩滤,水洗,干燥得原料药扑热息痛成品。其他的生产方法还有:(1)在冰醋酸中用锌还原对硝基苯酚,同时乙酰化得到对乙酰氨基酚;(2)将对羟基苯乙酮生成的腙,置于硫酸酸性溶液中,加入亚硝酸钠,转位生成对乙酰氨基酚。

合成制备方法

对氨基酚乙酰化而得。方法1：将对氨基酚加入稀乙酸中，再加入冰醋酸，升温至150℃反应7h，加入乙酐，再反应2h，检查终点，合格后冷却至25℃以下，甩滤，水洗至无乙酸味，甩干，得粗品。方法2：将对氨基酚、冰醋酸及含酸50%以上的酸母液一起蒸馏，蒸出稀酸的速度为每小时馏出总量的十分之一，待内温升至130℃以上，取样检查对氨基酚残留量低于2.5%，加入稀酸（含量50%以上），冷却结晶。甩滤，先用少量稀酸洗涤，再用大量水洗至滤液接近无色，得粗品。方法1的收率为90%，方法2的收率为90-95%。精制方法：将水加热至近沸时投入粗品。升温至全溶，加入用水浸泡过的活性炭，用稀乙酸调节至pH=4.2-4.6，沸腾10min。压滤，滤液加少量重亚硫酸钠。冷却至20℃以下，析出结晶。甩滤，水洗，干燥得原料药扑热息痛成品。其他的生产方法还有：（1）在冰醋酸中用锌还原对硝基苯酚，同时乙酰化得到对乙酰氨基酚；（2）将对羟基苯乙酮生成的腙，置于硫酸酸性溶液中，加入亚硝酸钠，转位生成对乙酰氨基酚。

用途简介

解热镇痛药。

用途

1.药物中间体。制造偶氮染料。照相化学药品。

N-乙酰对氨基酚毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE4200000

CHEMICAL NAME :: Acetanilide, 4'-hydroxy-

CAS REGISTRY NUMBER :: 103-90-2

BEILSTEIN REFERENCE NO. :: 2208089

LAST UPDATED :: 199806

DATA ITEMS CITED :: 92

MOLECULAR FORMULA :: C8-H9-N-O2

MOLECULAR WEIGHT :: 151.18

WISWESSER LINE NOTATION :: QR DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 591 mg/kg/2D-I

TOXIC EFFECTS :: Liver - liver function tests impaired Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - aplastic anemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 4962 ug/kg

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of endocrine pancreas Liver - liver function tests impaired Blood - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 714 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 1440 mg/kg/6D

TOXIC EFFECTS :: Behavioral - irritability Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 143 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 360 mg/kg/2D

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Liver - other changes Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 801 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Gastrointestinal - nausea or vomiting Liver - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 714 mg/kg

TOXIC EFFECTS :: Cardiac - EKG changes not diagnostic of specified effects

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 357 mg/kg

TOXIC EFFECTS :: Behavioral - anorexia (human) Behavioral - coma Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Behavioral - coma Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 490 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 143 mg/kg/24H-I

TOXIC EFFECTS :: Behavioral - anorexia (human) Liver - hepatitis (hepatocellular necrosis), zonal Liver - jaundice, other or unclassified

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Vascular - other changes Nutritional and Gross Metabolic - metabolic acidosis

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - acute pulmonary edema Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - coma Liver - liver function tests impaired Nutritional and Gross Metabolic - metabolic alkalosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1944 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1205 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 338 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 367 mg/kg

TOXIC EFFECTS :: Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 310 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Blood - changes in spleen Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 826 mg/kg

TOXIC EFFECTS :: Behavioral - analgesia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2620 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - tremor

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 512 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 891 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 105 gm/kg/35D-C

TOXIC EFFECTS :: Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 68 gm/kg/13W-C

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6080 mg/kg/19D-I

TOXIC EFFECTS :: Gastrointestinal - other changes Liver - changes in liver weight Blood - changes in leukocyte (WBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg/2D-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 136 gm/kg/13W-C

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 336 gm/kg/40W-C

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse Liver - other changes Liver - changes in liver weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 164 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 gm/kg/77W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - hepatitis (hepatocellular necrosis), zonal Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 gm/kg/77W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Endocrine - other changes

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 329 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 650 mg/kg

SEX/DURATION :: female 29 week(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - Apgar score (human only) Reproductive - Effects on Newborn - other neonatal measures or effects Reproductive - Effects on Newborn - other postnatal measures or effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 417 mg/kg

SEX/DURATION :: female 20 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - hepatobiliary system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1300 mg/kg

SEX/DURATION :: female 31-32 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Effects on Newborn - other neonatal measures or effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1500 mg/kg

SEX/DURATION :: female 8-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 12500 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating female 1-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - other postnatal measures or effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 35 gm/kg

SEX/DURATION :: male 70 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 25 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1 mmol/L

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,51,1988 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,307,1990 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,307,1990 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,307,1990 TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 TOXICOLOGY REVIEW AUHPAI Australian Journal of Hospital Pharmacy. (B.R. Miller, POB 125, Heidelberg, Vic., Australia) V.1- 1971- Volume(issue)/page/year: 3(3),100,1973 TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 12,601,1978 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB282-666 TOXICOLOGY REVIEW OBGNAS Obstetrics and Gynecology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1953- Volume(issue)/page/year: 58,57S,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80396 No. of Facilities: 1829 (estimated) No. of Industries: 7 No. of Occupations: 14 No. of Employees: 9269 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80396 No. of Facilities: 1261 (estimated) No. of Industries: 7 No. of Occupations: 26 No. of Employees: 65107 (estimated) No. of Female Employees: 56260 (estimated)

毒理学数据：

半数致死量（大鼠，经口）338 mg/kg.

生态数据：

对水是极其危害的，对鱼类有毒性，切勿让产品进入水体。

N-乙酰对氨基酚 MSDS

4'-羟基乙酰苯胺 修改号码：6

模块 1. 化学品
产品名称： 4'-Hydroxyacetanilide
修改号码： 6

模块 2. 危险性概述
  GHS分类
    　物理性危害        未分类
    　健康危害
    急性毒性（经口）      第4级
    生殖细胞敏感性      第2级
    特异性靶器官毒性      肝脏, 消化道, 心脏, 肾脏, 中枢神经系统
  - 单一接触 [第1级]
    特异性靶器官毒性      呼吸系统, 睾丸
  - 单一接触 [第2级]
    特异性靶器官毒性      肝脏, 血液（系统）, 肾脏
  - 单一接触 [第1级]
    特异性靶器官毒性        甲状腺
  - 单一接触 [第2级]
    　环境危害
    急性水生毒性      第2级
    慢性水生毒性      第2级
  GHS标签元素
    　图标或危害标志
    　信号词        危险
    　危险描述        吞咽有害。
    怀疑会造成遗传缺陷
    对器官引起损害：肝脏消化道心脏肾脏中枢神经系统
    可能对器官产生损害：呼吸系统睾丸
    可能因延长或接触对器官产生损害：肝脏血液（系统）肾
    脏
    可能因延长或接触对器官产生损害：甲状腺
  4'-羟基乙酰苯胺      修改号码：6

模块 2. 危险性概述
    对水生生物有毒性
    长期影响对水生生物有毒性
    　防范说明
  [预防]        使用前获取特定手册。
    处理前必须阅读并理解所有安全措施。
    切勿吸入。
    避免释放到环境中。
    使用本产品时切勿吃东西，喝水或吸烟。
    处理后要彻底清洗双手。
    使用个人所需的防护用具。
  [急救措施]      食入：若感不适，呼叫解毒中心/医生。漱口。
  如接触到或相关接触：求医/就诊。
    收集溢出物。
  [储存]        存放处须加锁。
  [废弃处置]      根据当地政府规定把物品/容器交与工业废弃处理机构。

模块 3. 成分/组成信息
  单一物质/混和物        单一物质
  化学名(中文名)：      4'-羟基乙酰苯胺
    百分比：      >98.0%(HPLC)(N)
  CAS编码：      103-90-2
    俗名：      4-Acetamidophenol , Acetaminophen , Paracetamol
    分子式：      C8H9NO2

模块 4. 急救措施
    吸入：      将受害者移到新鲜空气处，保持呼吸通畅，休息。求医/就诊。
    皮肤接触：      立即去除/脱掉所有被污染的衣物。用大量肥皂和水轻轻洗。
  求医/就诊。
    眼睛接触：        用水小心清洗几分钟。如果方便，易操作，摘除隐形眼镜。
  求医/就诊。
    食入：      求医/就诊。漱口。
    危害迹象：      腹痛, 腹泻, 嗜睡, 恶心, 意识丧失, 呕吐
    紧急救助者的防护：        救援者需要穿戴个人防护用品，比如橡胶手套和气密性护目镜。
    医生注意事项：        建议医学观察。

模块 5. 消防措施
    合适的灭火剂：        干粉，泡沫，雾状水，二氧化碳
    特殊危险性：        小心，燃烧或高温下可能分解产生毒烟。
    特定方法：        从上风处灭火，根据周围环境选择合适的灭火方法。
    非相关人员应该撤离至安全地方。
    周围一旦着火：如果安全，移去可移动容器。
    消防员的特殊防护用具：        灭火时，一定要穿戴个人防护用品。

模块 6. 泄漏应急处理
    个人防护措施，防护用具，      使用特殊的个人防护用品（针对有毒颗粒的P3过滤式空气呼吸器）。远离溢出物/泄露
    紧急措施：        处并处在上风处。
    泄露区应该用安全带等圈起来，控制非相关人员进入。
    环保措施：        小心，切勿排入河流等。因为考虑对环境有负面影响。
  4'-羟基乙酰苯胺      修改号码：6

模块 6. 泄漏应急处理
控制和清洗的方法和材料：清扫收集粉尘，封入密闭容器。注意切勿分散。附着物或收集物应该立即根据合适的
法律法规处置。

模块 7. 操作处置与储存
    处理
    技术措施：        在通风良好处进行处理。穿戴合适的防护用具。防止粉尘扩散。处理后彻底清洗双手
    和脸。
    注意事项：        如果可能，使用封闭系统。如果粉尘或浮质产生，使用局部排气。
    操作处置注意事项：        避免所有部位的接触！
    贮存
    储存条件：        保持容器密闭。存放于凉爽、阴暗处。
    存放处须加锁。
    远离不相容的材料比如氧化剂存放。
    包装材料：        依据法律。

模块 8. 接触控制和个体防护
    工程控制：        尽可能安装封闭体系或局部排风系统。同时安装淋浴器和洗眼器。
    个人防护用品
    　呼吸系统防护：      防尘面具，自携式呼吸器（SCBA），供气呼吸器等。使用通过政府标准的呼吸器。依
    据当地和政府法规。
    　手部防护：        防渗手套。
    　眼睛防护：        护目镜。如果情况需要，佩戴面具。
    　皮肤和身体防护：        防渗防护服。如果情况需要，穿戴防护靴。

模块 9. 理化特性
    固体
  外形（20°C）：
    外观：      晶体-粉末
    颜色：        白色类白色
    气味：        无味
  pH:      5.5 - 6.5 (saturated soln.H2O)
    熔点：
  169°C
  沸点/沸程        无资料
    闪点：        无资料
    爆炸特性
    　爆炸下限：        无资料
    　爆炸上限：        无资料
    蒸气压：      9.3x10-4Pa/25°C
    密度：        无资料
    溶解度：
  [水]      微溶于(1.4g/100mL, 20°C)
  [其他溶剂]
    溶于：      丙酮, 乙醇, 二甲基甲酰胺, 乙酸乙酯
    微溶于：        醚
    不溶于：      苯, 石油醚
  log水分配系数 =      0.49

模块 10. 稳定性和反应性
    化学稳定性：        一般情况下稳定。
    危险反应的可能性：        未报道特殊反应性。
  4'-羟基乙酰苯胺      修改号码：6

模块 10. 稳定性和反应性
须避免接触的物质氧化剂
危险的分解产物: 一氧化碳, 二氧化碳, 氮氧化物 (NOx)

模块 11. 毒理学信息
    急性毒性：      orl-rat LD50:1944 mg/kg
  scu-mus LD50:310 mg/kg
  ipr-rat LD50:1205 mg/kg
  orl-hmn LDLo:143 mg/kg
    对皮肤腐蚀或刺激：        无资料
    对眼睛严重损害或刺激：        无资料
    生殖细胞变异原性：      cyt-hmn-lym 200 mg/L
  cyt-hmn-orl 42860 ug/kg
  dns-rat-orl 500 mg/kg
  mmo-sat 100 ug/disc (+S9)
    致癌性：      orl-mus TDLo:135 g/kg/77W-C
  orl-rat TDLo:164 g/kg/78W-C
  IARC =      3 （无法对人类的致癌性进行分类）。
  NTP =        无资料
    生殖毒性：        无资料
  RTECS 号码:      AE4200000

模块 12. 生态学信息
    生态毒性：
    鱼类：      96h LC50:>100 mg/L (Oryzias latipes)
    甲壳类：      48h EC50:3.5 mg/L (Daphnia magna)
    藻类：      72h EC50:150 mg/L (Selenastrum capricornutum)
  残留性 / 降解性：        无资料
  潜在生物累积（BCF):        无资料
    土壤中移动性
  　log水分配系数：      0.49
  　土壤吸收系数（Koc）：        无资料
    　亨利定律        无资料
  constant(PaM3/mol):

模块 13. 废弃处置
如果可能，回收处理。请咨询当地管理部门。建议在可燃溶剂中溶解混合，在装有后燃和洗涤装置的化学焚烧炉中
焚烧。废弃处置时请遵守国家、地区和当地的所有法规。

模块 14. 运输信息
    联合国分类：      第9类杂类
  UN编号：      3077
    正式运输名称：      环境有害物质, 固体, 不另作详细说明
    包装等级：      III
  海洋污染物:      Y

模块 15. 法规信息
  《危险化学品安全管理条例》（2002年1月26日国务院发布，2011年2月16日修订）: 针对危险化学品的安全使用、
    生产、储存、运输、装卸等方面均作了相应的规定。
  4'-羟基乙酰苯胺      修改号码：6

模块16 - 其他信息
N/A