1-亚硝基-5,6-二氢尿嘧啶
- 中文名称：
- 1-亚硝基-5,6-二氢尿嘧啶
- 中文别名：
-
- 英文名称：
- 2,4(1H,3H)-Pyrimidinedione,dihydro-1-nitroso-
- 英文别名：
- 1-nitroso-1,3-diazinane-2,4-dione;
1-nitroso-dihydro-pyrimidine-2,4-dione;
NO-Dhu;
NDHU;
Hydrouracil,1-nitroso;
Uracil,5,6-dihydro-1-nitroso;
1-Nitroso-5,6-dihydrouracil
- CAS No.：
- 16813-36-8
- 分 子 式：
-
C4H5N3O3
- 分 子 量：
- 143.12
- 精确分子量：
- 143.03300
- PSA：
- 78.84000
- InChI：
- The Key: NTUQAPWIPIIWLT-UHFFFAOYSA-N3
- 安全术语：
- Moderately toxic by intraperitoneal route. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.
- 分子结构式：
-
- SDS：
- 查看
1-亚硝基-5,6-二氢尿嘧啶 物化性质
- 密度：
- 1.78g/cm3
- 折射率：
- 1.699
1-亚硝基-5,6-二氢尿嘧啶 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MX9280000
- CHEMICAL NAME :
- Hydrouracil, 1-nitroso-
- CAS REGISTRY NUMBER :
- 16813-36-8
- BEILSTEIN REFERENCE NO. :
- 0779636
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C4-H5-N3-O3
- MOLECULAR WEIGHT :
- 143.12
- WISWESSER LINE NOTATION :
- T6NVMVTJ ANO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 850 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.)
Liver - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 440 mg/kg/41W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1200 mg/kg/8D-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Musculoskeletal - tumors
Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3000 mg/kg/32W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - Kidney tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1200 mg/kg/1W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
- TYPE OF TEST :
- DNA damage
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 7 mmol/L
- REFERENCE :
- JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 73,515,1984
1-亚硝基-5,6-二氢尿嘧啶 海关数据
中国海关编码：2933599090
- 概述：
- 2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- 摘要/Summary：
- 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
