D-甲状腺素
- 中文名称：
- D-甲状腺素
- 中文别名：
- D-甲状腺素;
右甲状腺素钠
- 英文名称：
- D-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1)
- 英文别名：
- D-THYROXINE SODIUM SALT;
choloxin;
Eulipos;
lisolipin;
dextroid;
dynothel;
dethyrona;
biotirmone;
Travenon;
dextroxin;
detyroxin
- CAS No.：
- 137-53-1
- 分 子 式：
-
C15H11I4NO4.Na
- 分 子 量：
- 798.85
- 精确分子量：
- 798.66900
- PSA：
- 95.61000
- EINECS：
- 205-301-2
- 安全术语：
- An experimental teratogen. Experimental reproductive effects. Human systemic effects: hepatitis, liver function tests, increased body temperature. When heated to decomposition it emits toxic fumes of I−, NOx, and Na2O.
- 分子结构式：
-
- SDS：
- 查看
D-甲状腺素 物化性质
- 沸点：
- 576.3ºC at 760mmHg
- 闪点：
- 302.3ºC
- 蒸汽压：
- 4.02E-14mmHg at 25°C
D-甲状腺素 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XP3582990
- CHEMICAL NAME :
- Thyroxine, monosodium salt, D-
- CAS REGISTRY NUMBER :
- 137-53-1
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C15-H10-I4-N-O4.Na
- MOLECULAR WEIGHT :
- 798.85
- WISWESSER LINE NOTATION :
- QR BI FI DOR BI FI D1YZVO &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 12 ug/kg/12D-I
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), diffuse
Liver - liver function tests impaired
Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- JJMDAT Japanese Journal of Medicine. (Nankodo Co., Ltd., POB 5272, Tokyo
International 100-31, Japan) V.1-30, 1962-1991. For publisher information,
see IEDIEP. Volume(issue)/page/year: 23,282,1984
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1500 mg/kg/30D-C
- TOXIC EFFECTS :
- Vascular - BP elevation not characterized in autonomic section
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
- REFERENCE :
- TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 29,207,1970
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 222 mg/kg/24W-C
- TOXIC EFFECTS :
- Vascular - BP elevation not characterized in autonomic section
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - evidence of thyroid hyperfunction
- REFERENCE :
- TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 29,565,1970
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 29 mg/kg
- SEX/DURATION :
- female 1-29 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- DABBBA Dissertation Abstracts International, B: The Sciences and
Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann
Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 15 mg/kg
- SEX/DURATION :
- female 15-29 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - physical
- REFERENCE :
- DABBBA Dissertation Abstracts International, B: The Sciences and
Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann
Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 16 mg/kg
- SEX/DURATION :
- female 16-31 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
- REFERENCE :
- SDMEAL South Dakota Journal of Medicine. (South Dakota Medical Assoc., 608
West Ave. N, Sioux Falls, SD 57104) V.18- 1965-
Volume(issue)/page/year: 21,33,1968
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5407
No. of Facilities: 9 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 63 (estimated)
No. of Female Employees: 9 (estimated)
D-甲状腺素 分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:2
3.氢键受体数量:5
4.可旋转化学键数量:5
5.互变异构体数量:2
6.拓扑分子极性表面积95.6
7.重原子数量:25
8.表面电荷:0
9.复杂度:426
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:1
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:2
推荐供应商
湖北江民泰华化工有限公司
右甲状腺素钠
- 联系人：张经理
- 电 话：13396038321
- 手 机：13396038321
- Cas号：137-53-1
- 包装：25kg,200kg
- 纯度：99%
- 价格：洽谈
成都云希化工有限公司
甲状腺素钠
- 联系人：李
- 电 话：17380623303
- 手 机：17380623303
- Cas号：137-53-1
- 包装：1g,10g
- 纯度：95%
- 价格：洽谈
