7-去氮肌苷
- 中文名称：
- 7-去氮肌苷
- 中文别名：
- 7-去氮肌苷
- 英文名称：
- 4H-Pyrrolo[2,3-d]pyrimidin-4-one,1,7-dihydro-7-b-D-ribofuranosyl-(8CI,9CI)
- 英文别名：
- 4H-Pyrrolo[2,3-d]pyrimidin-4-one,1,7-dihydro-7-b-D-ribofuranosyl-(8CI,9CI);
Antibiotic XK-101-2;
7-Deazainosine
- CAS No.：
- 2862-16-0
- 分 子 式：
-
C11H13N3O5
- 分 子 量：
- 267.27
- 精确分子量：
- 267.08600
- PSA：
- 120.60000
- InChI：
- The Key: DPRSKJHWKNHBOW-KCGFPETGSA-N3
- 安全术语：
- Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
- 分子结构式：
-
- SDS：
- 查看
7-去氮肌苷 物化性质
- 密度：
- 1.9g/cm3
- 沸点：
- 624.8ºC at 760mmHg
- 闪点：
- 331.7ºC
- 折射率：
- 1.81
- 蒸汽压：
- 1.78E-16mmHg at 25°C
7-去氮肌苷 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UY9450000
- CHEMICAL NAME :
- 7H-Pyrrolo(2,3-d)pyrimidin-4-ol,
7-beta-D-ribofuranosyl-
- CAS REGISTRY NUMBER :
- 2862-16-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C11-H13-N3-O5
- MOLECULAR WEIGHT :
- 267.27
- WISWESSER LINE NOTATION :
- T56 BN GN INJ FQ I- BT5OTJ CQ DQ E1Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 26 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - peritonitis
Liver - hepatitis (hepatocellular necrosis), zonal
Lungs, Thorax, or Respiration - acute pulmonary edema
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
29,116,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - peritonitis
Liver - hepatitis (hepatocellular necrosis), zonal
Lungs, Thorax, or Respiration - acute pulmonary edema
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
29,116,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - peritonitis
Liver - hepatitis (hepatocellular necrosis), zonal
Lungs, Thorax, or Respiration - acute pulmonary edema
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
29,116,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - peritonitis
Liver - hepatitis (hepatocellular necrosis), zonal
Lungs, Thorax, or Respiration - acute pulmonary edema
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
29,116,1969
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 48 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
29,116,1969
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 48 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
29,116,1969
