含氮霉素
- 中文名称：
- 含氮霉素
- 中文别名：
- 含氮霉素;
阿佐霉素
- 英文名称：
- L-Norleucine, L-g-glutamyl-6-diazo-5-oxo-L-norleucyl-6-diazo-5-oxo-
- 英文别名：
- Diazomycin B;
Antibiotic produced by streptomyces ambofaciens;
Azotomycin;
Azotomycin sodium salt;
DuazomycinB;
Antibiotic-1719
- CAS No.：
- 7644-67-9
- 分 子 式：
-
C17H23N7O8
- 分 子 量：
- 453.47
- 精确分子量：
- 453.16100
- PSA：
- 267.74000
- InChI：
- The Key: MNHVIVWFCMBFCV-AVGNSLFASA-N3
- 安全术语：
- Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human gastrointestinal tract effects by intravenous route. When heated to decomposition it emits toxic fumes of NOx.
- 分子结构式：
-
- SDS：
- 查看
含氮霉素 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RC6310000
- CHEMICAL NAME :
- L-Norleucine,
6-diazo-N-(6-diazo-N-L-gamma-glutamyl-5-oxo-L-norleuc
yl)-5-oxo-
- CAS REGISTRY NUMBER :
- 7644-67-9
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C17-H23-N7-O8
- MOLECULAR WEIGHT :
- 453.47
- WISWESSER LINE NOTATION :
- QVYZ2VMY2V1UNN&VMYVQ2V1UNN
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 192 mg/kg/4D
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 105 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 31 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 99 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8 mg/kg/6W-I
- TOXIC EFFECTS :
- Liver - other changes
Endocrine - changes in adrenal weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 550 ug/kg/15D-I
- TOXIC EFFECTS :
- Liver - other changes
Endocrine - changes in adrenal weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 6 mg/kg/8W-I
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 66 mg/kg/4W-I
- TOXIC EFFECTS :
- Endocrine - hyperglycemia
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Ascites tumor
- DOSE/DURATION :
- 400 ug/L
- REFERENCE :
- NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
1957- Volume(issue)/page/year: 22,105,1975
