2-巯基-4-甲基-5-噻唑乙酸,34272-64-5，生产厂家，价格-洛克化工网移动版

2-巯基-4-甲基-5-噻唑乙酸

中文名称：: 2-巯基-4-甲基-5-噻唑乙酸

中文别名：: 2-巯基-4-甲基-5-噻唑乙酸;
头孢地嗪侧链酸;
MTAA/MMTA头孢地嗪侧链酸;
(2-巯基-4-甲基-噻唑-5-基)-乙酸;
2-巯基-4-甲基-1,3-噻唑-5-基乙酸;
5-(羧甲基)-2-巯基-4-甲基噻唑;
(2-巯基-4-甲基-5-噻唑基)乙酸

英文名称：: 5-Thiazoleacetic acid,2,3-dihydro-4-methyl-2-thioxo-

英文别名：: 2-Mercapto-4-methyl-5-thiazoleacetic acid;
(2-Mercapto-4-methyl-5-thiazolyl)acetic Acid;
2-mercapto-4-methylthiazole-5-yl acetic acid;
MMTA;
2-mercapto-4-methyl-1,3-thiazol-5-ylacetic acid;
2-Mercapto-4-Methyl-5-Thiazole;
5-(Carboxymethyl)-2-mercapto-4-methylthiazole;
2-Mercapto-4-methylthizaol-5-yl)acetic acid;
2-mercapto-4-methyl-5-thiazoleaceticaci;
5-carboxymethyl-4-methylthiazole-2-thiol;
2-MERCAPTO-4-METHYLTHIAZOLE-5-ACETIC ACID;
5-carboxymethyl-2-mercapto-4-methylthiazole;
2-Mercapto-4-methyl;
5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole;
4-Methyl-2-mercaptothiazole-5-acetic acid;
2-Mercapto-4-Methylthiazol

CAS No.：: 34272-64-5

分子式：: C₆H₇NO₂S₂

分子量：: 189.26

精确分子量：: 188.99200

PSA：: 117.23000

MDL：: MFCD00274599

EINECS：: 251-905-4

InChI：: The Key: KYBOCQHDFLVQIB-UHFFFAOYSA-N3

危险品标志：

风险术语：: R36/37/38

安全术语：: S26;S36

分子结构式：

SDS：: 查看

2-巯基-4-甲基-5-噻唑乙酸制备方法及用途

制备方法

1、抗生素头孢地嗪（Cefodizime）中间体

用途简介

用途

1、抗生素头孢地嗪（Cefodizime）中间体

2-巯基-4-甲基-5-噻唑乙酸物化性质

外观与性状：: 白色至淡黄色晶体粉末
密度：: 1.52g/cm3
熔点：: 207 °C (dec.)(lit.)
沸点：: 363.4ºC at 760mmHg
闪点：: 173.6ºC
其它信息：: 1.        性状：未确定

2.         密度（g/mL,20℃）：未确定

3.         相对蒸汽密度（g/mL,空气=1）：未确定

4.         熔点（ºC）：207

5.         沸点（ºC,常压）：未确定

6.         沸点（ºC,KPa）：未确定

7.         折射率：未确定

8.         闪点（ºC）：未确定

9.         比旋光度（º）：未确定

10.      自燃点或引燃温度（ºC）：未确定

11.      蒸气压（Pa,20ºC）：未确定

12.      饱和蒸气压（KPa,20ºC）：未确定

13.      燃烧热（KJ/mol）：未确定

14.      临界温度（ºC）：未确定

15.      临界压力（KPa）：未确定

16.      油水（辛醇/水）分配系数的对数值：未确定

17.      爆炸上限（%,V/V）：未确定

18.      爆炸下限（%,V/V）：未确定

19.     溶解性：未确定

2-巯基-4-甲基-5-噻唑乙酸安全信息

海关代码：: 2934100090
WGK_Germany：: 3
德国有关水污染物质的分类清单
危险类别码：: R36/37/38
安全说明：: S26-S36
RTECS号：: XJ1921000
安全标志：: S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
S36:穿戴合适的防护服装。
危险标志：: Xi: Irritant;

2-巯基-4-甲基-5-噻唑乙酸毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ1921000

CHEMICAL NAME :: 5-Thiazoleacetic acid, 2-mercapto-4-methyl-

CAS REGISTRY NUMBER :: 34272-64-5

LAST UPDATED :: 198306

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H7-O2-S2

MOLECULAR WEIGHT :: 175.25

WISWESSER LINE NOTATION :: T5N CSJ BSH D1VQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,497,1971

毒理学数据：

1、急性毒性：小鼠静脉注射LD50：1680mg/kg

2-巯基-4-甲基-5-噻唑乙酸 MSDS

(2-Mercapto-4-methyl-5-thiazolyl)acetic Acid Revision number: 5.3
SAFETY DATA SHEET

Section 1. IDENTIFICATION
  Product name:        (2-Mercapto-4-methyl-5-thiazolyl)acetic Acid

  Revision number:        5.3

Section 2. HAZARDS IDENTIFICATION
  GHS classification
  PHYSICAL HAZARDS        Not classified
  HEALTH HAZARDS
  Skin corrosion/irritation        Category 2
    Category 2A
  Serious eye damage/eye irritation
  ENVIRONMENTAL HAZARDS        Not classified
  GHS label elements, including precautionary statements
  Pictograms or hazard symbols
  Signal word        Warning
  Hazard statements        Causes skin irritation
    Causes serious eye irritation
  Precautionary statements:
    Wash hands thoroughly after handling.
  [Prevention]
    Wear protective gloves/eye protection/face protection.
    IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
  [Response]
    if present and easy to do. Continue rinsing.
    If eye irritation persists: Get medical advice/attention.
    IF ON SKIN: Gently wash with plenty of soap and water.
    If skin irritation occurs: Get medical advice/attention.
    Take off contaminated clothing and wash before reuse.

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
  Substance/mixture:        Substance
  Components:        (2-Mercapto-4-methyl-5-thiazolyl)acetic Acid
  Percent:        >98.0%(GC)(T)
  CAS Number:        34272-64-5
  Synonyms:        5-(Carboxymethyl)-2-mercapto-4-methylthiazole
    C6H7NO2S2
  Chemical Formula:

Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.

Section 4. FIRST AID MEASURES
  Skin contact:        Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
    soap and water. If skin irritation or rash occurs: Get medical advice/attention.
  Eye contact:        Rinse cautiously with water for several minutes. Remove contact lenses, if present
    and easy to do. Continue rinsing. If eye irritation persists: Get medical
    advice/attention.
  Ingestion:        Get medical advice/attention if you feel unwell. Rinse mouth.
    A rescuer should wear personal protective equipment, such as rubber gloves and air-
  Protection of first-aiders:
    tight goggles.

Section 5. FIRE-FIGHTING MEASURES
  Suitable extinguishing        Dry chemical, foam, water spray, carbon dioxide.
  media:
  Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
  from the chemical:        generate poisonous fume.
  Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
    method according to the surrounding situation is used. Uninvolved persons should
    evacuate to a safe place. In case of fire in the surroundings: Remove movable
    containers if safe to do so.
  Special protective        When extinguishing fire, be sure to wear personal protective equipment.
  equipment for firefighters:

Section 6. ACCIDENTAL RELEASE MEASURES
  Personal precautions,        Use personal protective equipment. Keep people away from and upwind of spill/leak.
  protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
  emergency procedures: roping off, etc.
  Environmental precautions: Prevent product from entering drains.
  Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
  containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
  up: appropriate laws and regulations.

Section 7. HANDLING AND STORAGE
  Precautions for safe handling
  Technical measures:        Handling is performed in a well ventilated place. Wear suitable protective equipment.
    Prevent dispersion of dust. Wash hands and face thoroughly after handling.
    Use a local exhaust if dust or aerosol will be generated.
  Advice on safe handling: Avoid contact with skin, eyes and clothing.
  Conditions for safe storage, including any
  incompatibilities
  Storage conditions:        Keep container tightly closed. Store in a cool and dark place.
    Store away from incompatible materials such as oxidizing agents.
  Packaging material:        Comply with laws.

Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
  Engineering controls:        Install a closed system or local exhaust as possible so that workers should not be
    exposed directly. Also install safety shower and eye bath.
  Personal protective equipment
  Respiratory protection: Dust respirator. Follow local and national regulations.
  Hand protection:        Protective gloves.
    Safety glasses. A face-shield, if the situation requires.
  Eye protection:
  Skin and body protection: Protective clothing. Protective boots, if the situation requires.

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
  Physical state (20°C):        Solid
    Crystal- Powder
  Form:
  Colour:        White - Slightly pale yellow
    No data available
  Odour:

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
  pH: No data available
  Melting point/freezing point:211°C (dec.)
  Boiling point/range:        No data available
  Flash point:        No data available
  Flammability or explosive
  limits:
  Lower:        No data available
  Upper:        No data available
  Relative density:        No data available
  Solubility(ies):
  [Water]        No data available
  [Other solvents]        No data available

Section 10. STABILITY AND REACTIVITY
  Chemical stability:        Stable under proper conditions.
  Possibility of hazardous No special reactivity has been reported.
  reactions:
  Incompatible materials: Oxidizing agents
  Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx), Sulfur oxides
  products:

Section 11. TOXICOLOGICAL INFORMATION
  Acute Toxicity:        ivn-mus LD50:1680 mg/kg
  Skin corrosion/irritation: No data available
  Serious eye        No data available
  damage/irritation:
  Germ cell mutagenicity: No data available
  Carcinogenicity:
    No data available
  IARC =
  NTP =        No data available
  Reproductive toxicity:        No data available
  RTECS Number:        XJ1921000

Section 12. ECOLOGICAL INFORMATION
  Ecotoxicity:
  Fish:        No data available
  Crustacea:        No data available
    No data available
  Algae:
  Persistence / degradability: No data available
    No data available
  Bioaccumulative
  potential(BCF):
  Mobility in soil
  Log Pow:        No data available
  Soil adsorption (Koc):        No data available
  Henry's Law        No data available
  constant(PaM3/mol):

Section 13. DISPOSAL CONSIDERATIONS
    Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
    with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
    Observe all federal, state and local regulations when disposing of the substance.

Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not listed

Section 15. REGULATORY INFORMATION
  Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
  and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
    loading and unloading were prescribed.

SECTION 16 - ADDITIONAL INFORMATION
N/A

2-巯基-4-甲基-5-噻唑乙酸海关数据

中国海关编码：2934100090

概述：: 2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素：: 品名, 成分含量, 用途
摘要/Summary：: 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

2-巯基-4-甲基-5-噻唑乙酸分子结构与计算化学数据

计算化学数据

1.疏水参数计算参考值（XlogP）:0.7

2.氢键供体数量:2

3.氢键受体数量:4

4.可旋转化学键数量:2

5.互变异构体数量:2

6.拓扑分子极性表面积107

7.重原子数量:11

8.表面电荷:0

9.复杂度:247

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

2-巯基-4-甲基-5-噻唑乙酸上游产品

头孢地嗪钠; (6R,7R)-7-[(2-氨基-4-噻唑基)-(甲氧亚氨基)乙酰氨基]-3-[[(5-羧甲基-4-甲基-2-噻唑基)硫]甲基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸二钠盐