(1R,αS)-α-氨基-2-亚甲基环丙烷丙酸
- 中文名称：
- (1R,αS)-α-氨基-2-亚甲基环丙烷丙酸
- 中文别名：
- (1R,αS)-α-氨基-2-亚甲基环丙烷丙酸
- 英文名称：
- Cyclopropanepropanoicacid, a-amino-2-methylene-, (aS,1R)-
- 英文别名：
- S-Hypoglycine A;
Cyclopropanepropanoicacid, a-amino-2-methylene-, (aS,1R)-
- CAS No.：
- 156-56-9
- 分 子 式：
-
C7H11NO2
- 分 子 量：
- 141.17
- 精确分子量：
- 141.07900
- PSA：
- 63.32000
- InChI：
- The Key: OOJZCXFXPZGUBJ-GDVGLLTNSA-N3
- 安全术语：
- Poison by ingestion, intravenous, and intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
- 分子结构式：
-
- SDS：
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(1R,αS)-α-氨基-2-亚甲基环丙烷丙酸 物化性质
- 密度：
- 1.16g/cm3
- 熔点：
- 280-284ºC
- 沸点：
- 269.1ºC at 760 mmHg
- 闪点：
- 116.6ºC
- 折射率：
- 1.528
- 蒸汽压：
- 0.0021mmHg at 25°C
(1R,αS)-α-氨基-2-亚甲基环丙烷丙酸 安全信息
(1R,αS)-α-氨基-2-亚甲基环丙烷丙酸 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GZ2215000
- CHEMICAL NAME :
- Cyclopropanepropionic acid, alpha-amino-2-methylene-,
L-(+)-
- CAS REGISTRY NUMBER :
- 156-56-9
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C7-H11-N-O2
- MOLECULAR WEIGHT :
- 141.19
- WISWESSER LINE NOTATION :
- L3YTJ AU1 B1YZVQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 98 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - somnolence (general depressed activity)
Gastrointestinal - nausea or vomiting
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 13,125,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 97 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- WIMJAD West Indian Medical Journal. (Univ. of the West Indies, Faculty of
Medicine, Kingston 7, Jamaica) V.1- 1951- Volume(issue)/page/year:
16,193,1967
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 121,272,1957
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 62 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 121,272,1957
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 121,272,1957
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 121,272,1957
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Endocrine - hypoglycemia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 121,272,1957
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Bird - pigeon
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 121,272,1957
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- female 1-5 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 6,813,1968
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 30 mg/kg
- SEX/DURATION :
- female 3-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- REFERENCE :
- NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year:
55,39,1968
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 180 mg/kg
- SEX/DURATION :
- female 1-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - body wall
- REFERENCE :
- LSBGAY Life Sciences, Part 2: Biochemistry, General and Molecular Biology.
(New York, NY) V.9-13, 1970-73. For publisher information, see LIFSAK.
Volume(issue)/page/year: 9,1305,1970
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 5 mg/kg
- SEX/DURATION :
- female 1-10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- REFERENCE :
- WIMJAD West Indian Medical Journal. (Univ. of the West Indies, Faculty of
Medicine, Kingston 7, Jamaica) V.1- 1951- Volume(issue)/page/year:
17,52,1968
*** REVIEWS ***
TOXICOLOGY REVIEW
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 5,77,1972
(1R,αS)-α-氨基-2-亚甲基环丙烷丙酸 海关数据
中国海关编码：2922499990
- 概述：
- 2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%
- 申报要素：
- 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
- 监管条件：
- A.入境货物通关单B.出境货物通关单
- 检验检疫：
- P.进境动植物、动植物产品检疫Q.出境动植物、动植物产品检疫R.进口食品卫生监督检验S.出口食品卫生监督检验M.进口商品检验N.出口商品检验
- 摘要/Summary：
- HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%
(1R,αS)-α-氨基-2-亚甲基环丙烷丙酸 分子结构与计算化学数据
分子结构数据
1、 摩尔折射率：37.17
2、 摩尔体积（cm3/mol）：120.6
3、 等张比容（90.2K）：314.0
4、 表面张力（dyne/cm）：45.8
5、 极化率（10-24cm3）：14.73
(1R,αS)-α-氨基-2-亚甲基环丙烷丙酸 下游产品
