3-(2-硝基-1H-咪唑-1-基)-1,2-丙二醇
- 中文名称：
- 3-(2-硝基-1H-咪唑-1-基)-1,2-丙二醇
- 中文别名：
- 3-(2-硝基-1H-咪唑-1-基)-1,2-丙二醇;
3-(2-硝基-1H-咪唑基-1-基)丙烷-1,2-二醇
- 英文名称：
- 1,2-Propanediol,3-(2-nitro-1H-imidazol-1-yl)-
- 英文别名：
- 3-(2-nitroimidazol-1-yl)propane-1,2-diol;
2-Hydroxy-3-(2-nitro-1-imidazolyl)-propanol;
Desmethylmisonidazole;
EINECS 236-932-1;
3-(2-Nitro-1H-imidazol-1-yl)propane-1,2-diol;
1-(2-nitro-1-imidazolyl)-3-hydroxypropanol;
Ro 5-9963;
O-Desmethyl-misonidazole;
3-(2-nitro-imidazol-1-yl)-propane-1,2-diol;
3-(2-Nitro-I-imidazolyl)-1,2-propanediol;
1-(2,3-dihydroxypropyl)-2-nitroimidazole;
Demethylmisonidazole
- CAS No.：
- 13551-92-3
- 分 子 式：
-
C6H9N3O4
- 分 子 量：
- 187.18
- 精确分子量：
- 187.05900
- PSA：
- 104.10000
- EINECS：
- 236-932-1
- InChI：
- The Key: NUGLIYXAARVRPQ-UHFFFAOYSA-N3
- 安全术语：
- Moderately toxic by intravenous and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
- 分子结构式：
-
- SDS：
- 查看
3-(2-硝基-1H-咪唑-1-基)-1,2-丙二醇 物化性质
- 密度：
- 1.61g/cm3
- 沸点：
- 521.5ºC at 760mmHg
- 闪点：
- 269.2ºC
- 折射率：
- 1.643
- 蒸汽压：
- 1.05E-11mmHg at 25°C
3-(2-硝基-1H-咪唑-1-基)-1,2-丙二醇 安全信息
3-(2-硝基-1H-咪唑-1-基)-1,2-丙二醇 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TZ0818000
- CHEMICAL NAME :
- 1,2-Propanediol, 3-(2-nitroimidazol-1-yl)-
- CAS REGISTRY NUMBER :
- 13551-92-3
- BEILSTEIN REFERENCE NO. :
- 0613156
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C6-H9-N3-O4
- MOLECULAR WEIGHT :
- 187.18
- WISWESSER LINE NOTATION :
- T5N CNJ A1YQ1Q BNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5076 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2532 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Gastrointestinal - contraction (isolated tissue)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2730 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal)
Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9020 mg/kg/20D-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 3340 mg/kg/20D-I
- TOXIC EFFECTS :
- Behavioral - ataxia
Blood - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 2250 mg/kg/20D-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes
Behavioral - ataxia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - mouse Embryo
- DOSE/DURATION :
- 1 mmol/L/3D (Continuous)
- REFERENCE :
- 45OJAG "Radiation Sensitizers: Their Use in the Clinical Management of
Cancer, Proceedings of the Conference, Key Biscayne, FL, 1979," Brady, L.W.,
ed., New York, Masson Pub. USA, Inc., 1980 Volume(issue)/page/year:
-,146,1980
3-(2-硝基-1H-咪唑-1-基)-1,2-丙二醇 海关数据
中国海关编码：2933290090
- 概述：
- 2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- 摘要/Summary：
- 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
3-(2-硝基-1H-咪唑-1-基)-1,2-丙二醇 上游产品
