1,2-二溴乙烷,106-93-4，生产厂家，价格-洛克化工网移动版

返回



基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

结构与计算化学

表征图谱

1,2-二溴乙烷

中文名称：: 1,2-二溴乙烷

中文别名：: 二溴乙烷;
溴化乙烯;
乙撑二溴;
二溴化乙烷;
二溴化乙烯;
溴化乙烷;
亚乙基二溴;
1,2-二溴乙烷(EDB)

英文名称：: 1,2-Dibromoethane

英文别名：: 1,2-dibromoethane;
ETHYLENE DIBROMIDE;
sym-Dibromoethane;
Bromuro di etile;
ethylene dibromide;
Ethylene Dibromide;
1,2-Ethylene dibromide;
1,2-Dibromoethane;
Glycol bromide;
Ethylene Bromide;
Ethylene bromide;
1,2-bromoethane;
1,2-dibromo ethylene;
Ethane,1,2-dibromo;
1,2-dibromo-ethane;
Dibromoethane;
EDB

CAS No.：: 106-93-4

分子式：: C₂H₄Br₂

分子量：: 187.86

精确分子量：: 185.86800

PSA：: 0.00000

MDL：: MFCD00000233

EINECS：: 203-444-5

InChI：: InChI=1/C2H4Br2/c3-1-2-4/h1-2H23

危险品标志：: TN

风险术语：: R23/24/25; R36/37/38;R45;

安全术语：: S45; S53; S61;

分子结构式：

SDS：: 查看

1,2-二溴乙烷物化性质

外观与性状：: 透明液体
密度：: 2.18 g/mL at 25 °C(lit.)
熔点：: 9 °C
沸点：: 131-132 °C(lit.)
闪点：: 132°C
水溶解性：: 4 g/L (20 ºC)
折射率：: n20/D 1.539(lit.)
蒸汽压：: 12mmHg at 25°C
蒸汽密度：: ~6.5 (vs air)
存储条件/存储方法：: 库房通风低温干燥,与氧化剂、食品添加剂分开存放
稳定性相关：: 1.在光作用下部分发生分解。与强碱反应生成溴代乙烯。
2.蒸气有毒，浓度高时能引起麻醉作用，全麻时会引起肺水肿致死。空气中最低中毒浓度２５×１０－６。吸入致死浓度１０００×１０－６。对啮齿动物有致癌作用。空气中最高容许浓度１３０×１０－９。蒸气刺激呼吸道，损伤肝、肾。液体接触皮肤可致溃烂。受到沾污时，应立即脱去外衣，擦干皮肤。生产场所要求通风良好，备有防毒面具和防护服等。
3.具有中度麻醉作用，易被皮肤吸收，其蒸气刺激眼黏膜和上呼吸道。麻醉性小，但能引起感觉迟钝、抑郁、呕吐。服用40g即可致死。慢性中毒时，能引起眼球结膜炎、支气管炎、喉头炎、食欲不振、抑郁等症状。潜在致癌物。嗅觉阈浓度199.94mg/m3。工作场所最高容许浓度为192.25 mg/m3。
4.稳定性^[20] 稳定
5.禁配物^[21] 碱金属、强氧化剂
6.避免接触的条件^[22] 光照、受热
7.聚合危害^[23] 不聚合
8.分解产物^[24] 溴化氢
其它信息：: 1.性状：无色有甜味的液体，有氯仿味。^[1]
2.熔点（℃）：9.97^[2]
3.沸点（℃）：131~132^[3]
4.相对密度（水=1）：2.17^[4]
5.相对蒸气密度（空气=1）：6.48^[5]
6.饱和蒸气压（kPa）：2.32（30℃）^[6]
7.临界压力（MPa）：7.15^[7]
8.辛醇/水分配系数：1.96^[8]
9.溶解性：微溶于水，可混溶于多数有机溶剂。^[9]
10.黏度（mPa·s,25ºC）：0.01613
11.蒸发热（KJ/mol,b.p.）：190.9
12.熔化热（KJ/mol）：10.84
13.生成热（KJ/mol,25ºC,液体）：80.805
14.燃烧热（KJ/mol,液体）：1217.9
15.比热容（KJ/(kg·K),定压）：0.72
16.电导率（S/m,25ºC）：1.28×10^-11
17.溶解度（%,水,25ºC）：0.54
18.体膨胀系数（K^-1,15~30ºC）：0.000958
19.相对密度（20℃，4℃）：2.1791
20.常温折射率（n²⁰）：1.5387
21.溶度参数(J·cm^-3)^0.5：20.656
22.van der Waals面积（cm²·mol^-1）：6.860×10⁹
23.van der Waals体积（cm³·mol^-1）：49.260
24.气相标准声称热(焓)( kJ·mol^-1) ：-37.5
25.气相标准熵(J·mol^-1·K^-1) ：329.74
26.气相标准生成自由能( kJ·mol^-1)：-9.17
27.液相标准声称热(焓)( kJ·mol^-1)：-79.2
28.液相标准熵(J·mol^-1·K^-1) ：223.30
29.液相标准生成自由能( kJ·mol^-1)：-17.6
30.液相标准热熔(J·mol^-1·K^-1)：131.8

1,2-二溴乙烷毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KH9275000

CHEMICAL NAME :: Ethane, 1,2-dibromo-

CAS REGISTRY NUMBER :: 106-93-4

BEILSTEIN REFERENCE NO. :: 0605266

LAST UPDATED :: 199712

DATA ITEMS CITED :: 164

MOLECULAR FORMULA :: C2-H4-Br2

MOLECULAR WEIGHT :: 187.88

WISWESSER LINE NOTATION :: E2E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - urine volume decreased

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 108 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14300 mg/m3/30M

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 146 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - body temperature decrease Skin and Appendages - corrosive (after topical exposure)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Liver - hepatitis (hepatocellular necrosis), diffuse

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 400 ppm/3H

TOXIC EFFECTS :: Nutritional and Gross Metabolic - conditioned vitamin deficiency Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - hepatitis (hepatocellular necrosis), zonal

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 79 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 ppm/6H/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 ppm/7H/9D-I

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg/2D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 ppm/6H/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 50 ppm/7H/70D-I

TOXIC EFFECTS :: Behavioral - excitement Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 ppm/7H/4D-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 50 ppm/7H/80D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - changes in lung weight Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 162 mg/kg/7D-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Biochemical - Metabolism (Intermediary) - lipids including transport

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 486 mg/kg/21D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 540 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Blood - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 ppm/6H/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Vascular - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16 gm/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 ppm/6H/90W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 190 gm/kg/62W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 840 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 gm/kg/61W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23 gm/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24 gm/kg/57W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6630 mg/kg/34W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 gm/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 ppm/7H/78W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - adrenal cortex tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7000 mg/kg/47W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 gm/kg/44W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 ppm/6H/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 ppm/6H/88W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Vascular - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 88 ppb/8H

SEX/DURATION :: male 5 year(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 66670 ppb/4H

SEX/DURATION :: female 3-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 80 ppm/23H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 89 ppm/7H

SEX/DURATION :: male 10 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 39 ppm/7H

SEX/DURATION :: female 3 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 80 ppm/7H

SEX/DURATION :: female 3 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 25 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 38 ppm/23H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 20 ppm/23H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 38 ppm/23H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 32 ppm/23H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 225 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 40 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 93600 ug/kg

SEX/DURATION :: male 12 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Heritable translocation test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TEST SYSTEM :: Mammal - species unspecified

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 18,743,1980 *** REVIEWS *** ACGIH TLV-Animal carcinogen (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,195,1977 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,204,1987 IARC Cancer Review:Group 2A IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,204,1987 TOXICOLOGY REVIEW BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925- Volume(issue)/page/year: 54,413,1978 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB83-184325 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 20 ppm (145 mg/m3) (skin) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,15,1973 OSHA PEL (Gen Indu):8H TWA 20 ppm;CL 30 ppm;Pk 50 ppm/5M/8H CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 25 ppm (190 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 25 ppm (190 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 25 ppm (190 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.13 ppm (1 mg/m3) JAN 1993 OEL-AUSTRALIA;Skin;Carcinogen JAN 1993 OEL-BELGIUM;Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.1 ppm (1 mg/m3);Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 20 ppm (145 mg/m3);STEL 30 ppm;Skin;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-HUNGARY:STEL 0.8 mg/m3;Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 20 ppm (155 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 25 ppm (190 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 100 mg/m3 JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.8 mg/m3);Skin;Carcinogen JAN 1993 OEL-THAILAND:TWA 20 ppm;STEL 30 ppm JAN 1993 OEL-TURKEY:TWA 25 ppm (190 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 1 ppm (8 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ETHYLENE DIBROMIDE-air:CA TWA 0.045 ppm;CL 0.13 ppm/15M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 23660 No. of Facilities: 438 (estimated) No. of Industries: 5 No. of Occupations: 8 No. of Employees: 7921 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 23660 No. of Facilities: 496 (estimated) No. of Industries: 7 No. of Occupations: 13 No. of Employees: 8559 (estimated) No. of Female Employees: 792 (estimated)

毒理学数据：

1.急性毒性^[10]

LD50：108mg/kg（大鼠经口）；300mg/kg（大鼠经皮）；300mg/kg（兔经皮）

LC50：14300mg/m³,（大鼠吸入，30min）

2.刺激性^[11] 家兔经皮：1%，14d，严重刺激。

3.致突变性^[12] 微生物致突变：鼠伤寒沙门菌500nmol/皿；大肠杆菌20μl/皿。姐妹染色单体交换：人淋巴细胞10nmol/L。微核试验：人淋巴细胞1mmol/L。DNA抑制：人淋巴细胞5ml/L。哺乳动物体细胞突变：人淋巴细胞5mg/L。

4.致畸性^[13] 大鼠孕后6~15d吸入最低中毒剂量（TCLo）32ppm（23h），致肌肉骨骼系统发育畸形。

5.致癌性^[14] IARC致癌性评论：G2A，可能人类致癌物。

6.其他^[15] 大鼠吸入最低中毒浓度（TCLo）：80ppm（24h），致胎鼠死亡。大鼠吸入最低中毒浓度（TCLo）；对睾丸、附睾、输精管、性腺、尿道及雄性生育指数有影响。

生态数据：

1.生态毒性^[16] LC50：18mg/L（48h）（蓝鳃太阳鱼）

2.生物降解性^[17]

好氧生物降解（h）：672~4320

厌氧生物降解（h）：48~360

3.非生物降解性^[18]

空气中光氧化半衰期（h）：257~2567

一级水解半衰期（h）：19272

4.其他有害作用^[19] 该物质对环境有危害，对哺乳动物和鸟类应给予特别注意。

1,2-二溴乙烷 MSDS

国标编号:	61565
ＣＡＳ:	106-93-4
中文名称:	1，2-二溴乙烷
英文名称:	1，2-dibromoethane
别名:	乙撑二溴
分子式:	C₂H₄Br₂；BrCH₂CH₂Br
分子量:	187.88
熔点:	9.3℃ 沸点：131.4℃
密度:	相对密度(水=1)2.17；
蒸汽压:	30℃
溶解性:	微溶于水，可混溶于多数有机溶剂
稳定性:	稳定
外观与性状:	无色质重有甜味的液体
危险标记:	14(有毒品)
用途:	用作溶剂，用于有机合成，制造杀虫剂、药品等

2、对环境的影响
该物质对环境有危害，对大气臭氧层有极强破坏力。对哺乳动物和鸟类应给予特别注意。
一、健康危害
侵入途径：吸入、食入、经皮吸收。
健康危害：具有中度麻醉作用。对皮肤粘膜有刺激作用。重者可致肺炎和肺水肿。对中枢神经有抑制作用。可致肝、肾损害。
急性中毒：可有头痛、头晕、耳鸣、全身无力、面色苍白、恶心、呕吐，可死于心力衰竭。引起皮炎和结膜炎。
二、毒理学资料及环境行为
毒性：潜在致癌物。
急性毒性：LD₅₀108mg/kg(大鼠经口)；300mg/kg(兔经皮)；LC₅₀0.384g/m³(大鼠吸入)；人经口140mg/kg，致死。
亚急性慢性毒性：大鼠/兔吸入0.768g/m³×7小时/日×5日/周×6个月，实验动物死亡率较对照高存活动物和肺、肝、肾重量增加。
致突变性：微生物致突变：鼠伤寒沙门氏菌500nmol/皿；大肠杆菌20uL/皿。姊妹染色体交换：人淋巴细胞10nmol/L。
生殖毒性：大鼠吸入最低中毒浓度(TCL0)：80ppm (24小时)，致胎鼠死亡。大鼠吸入最低中毒浓度(TCL0)对睾丸、附睾、输精管、性腺、尿道及雄性生育指数有影响。
致癌性：大鼠吸入20ppm×7小时/日×18月，肝细胞癌及肝血管肉瘤等。
危险特性：受高热分解产生有毒的溴化物气体。与强氧化剂接触可发生化学反应。
燃烧(分解)产物：溴化氢。 3、现场应急监测方法
　 4、实验室监测方法
气相色谱法《水和废水标准检验法》19版译文，江苏省监测中心
色谱/质谱法，美国EPA524.2方法 5、环境标准

美国	车间卫生标准	5ppm
美国(1981)	食物和饲料中容许残留限值	0.001mg/kg(大豆)
	嗅觉阈浓度	26ppm

6、应急处理处置方法

一、泄漏应急处理
迅速撤离泄漏污染区人员至安全区，并立即隔离150米，严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿防毒服。不要直接接触泄漏物。尽可能切断泄漏源，防止进入下水道、排洪沟等限制性空间。小量泄漏：用砂土、蛭石或其它惰性材料吸收。大量泄漏：构筑围堤或挖坑收容。用泡沫覆盖，降低蒸气灾害。用泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。
废弃物处置方法：用控制焚烧法，焚烧系统要按装洗涤器和贮灰装

1,2-二溴乙烷

1,2-二溴乙烷制备方法及用途

合成制备方法

用途

1,2-二溴乙烷物化性质

1,2-二溴乙烷安全信息

1,2-二溴乙烷毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

1,2-二溴乙烷 MSDS

1,2-二溴乙烷分子结构与计算化学数据

分子结构数据

计算化学数据

1,2-二溴乙烷表征图谱

推荐供应商

1,2-二溴乙烷

1,2-二溴乙烷 制备方法及用途

合成制备方法

用途

1,2-二溴乙烷 物化性质

1,2-二溴乙烷 安全信息

1,2-二溴乙烷 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

1,2-二溴乙烷 MSDS

1,2-二溴乙烷 分子结构与计算化学数据

分子结构数据

计算化学数据

1,2-二溴乙烷 表征图谱

推荐供应商

1,2-二溴乙烷制备方法及用途

1,2-二溴乙烷物化性质

1,2-二溴乙烷安全信息

1,2-二溴乙烷毒理性

1,2-二溴乙烷分子结构与计算化学数据

1,2-二溴乙烷表征图谱