间苯二胺,108-45-2，生产厂家，价格-洛克化工网移动版

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间苯二胺

中文名称：: 间苯二胺

中文别名：: 间苯二胺;
二胺苯;
3-二氨基苯;
1,3-苯二胺;
M-苯二胺

英文名称：: 1,3-Benzenediamine

英文别名：: 1,3-phenylenediamine;
benzene-1,3-diamine;
m-Phenylenediamine;
meta-Phenylenediamine (MPD);
Benzene-1,3-diamine

CAS No.：: 108-45-2

分子式：: C₆H₈N₂

分子量：: 108.14

精确分子量：: 108.06900

PSA：: 52.04000

MDL：: MFCD00007799

EINECS：: 203-584-7

BRN：: 471357

InChI：: InChI=1/C6H8N2/c7-5-2-1-3-6(8)4-5/h1-4H,7-8H23

危险品标志：: TN

风险术语：: R23/24/25;R36;R40;

安全术语：: S28A;S36/37;S45;

分子结构式：

SDS：: 查看

间苯二胺制备方法及用途

制备方法

硝基苯经混酸硝化成间、邻、对二硝基苯的混合物,再经亚硫酸钠和液碱精制得间二硝基苯,然后用铁粉还原或加氢还原制得间苯二胺。工艺过程:

合成制备方法

硝基苯经混酸硝化成间、邻、对二硝基苯的混合物，再经亚硫酸钠和液碱精制得间二硝基苯，然后用铁粉还原或加氢还原制得间苯二胺。工艺过程：

用途简介

偶氮染料和吖嗪染料的中间体，主要用于制造直接耐晒黑rN、碱性橙、碱性棕G、直接耐晒黑G等染料，并用作毛皮染料，在日本，偶氮染料消费的间苯二胺占总消费量的90%。也用作环氧树脂的固化剂、水泥的促凝剂，并用于染发水、媒染剂、显色剂等方面。

用途

1.用作分析试剂、树脂固化剂和阻聚剂，也用于染料的合成。偶氮染料和吖嗪染料的中间体，主要用于制造直接耐晒黑RN、碱性橙、碱性棕G、直接耐晒黑G等染料，并用作毛皮染料，在日本，偶氮染料消费的间苯二胺占总消费量的90%。也用作水泥的促凝剂，并用于染发水、媒染剂、显色剂等方面。

2.本品用作环氧树脂固化剂。固化条件为80～90℃/30min+150℃/1～2h。主要用于层压制品、浇铸制品及黏合剂等。对液态环氧树脂用量为14～16份。固化物的耐热性、耐药品性、电气性能优良，即使在高温下也能保持这些特性。本品是偶氮染料和嗪染料的中间体，并用作毛皮染料及水泥的促凝剂等。

3.用作环氧树脂耐高温固化剂，固化条件80℃/2h+150℃/2h，参考用量14～16质量份。一般先熔化制成过冷液体，易与环氧树脂混合均匀。间苯二胺变成棕黑色对环氧树脂的固化基本无影响，固化物颜色较深。耐热性、耐水性及耐药剂性能良好，热变形温度150～155℃，可在150℃长期使用。也用于制造偶氮染料、嗪染料及活性染料，还用作水泥促凝剂、石油添加剂及制造医药品的原料等。

4.用作光度法测定亚硝酸盐和水中活性氯的试剂。

5.用作染料中间体，环氧树脂的固化剂和水泥的促凝剂。^[27]

间苯二胺毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SS7700000

CHEMICAL NAME :: m-Phenylenediamine

CAS REGISTRY NUMBER :: 108-45-2

BEILSTEIN REFERENCE NO. :: 0471357

LAST UPDATED :: 199712

DATA ITEMS CITED :: 45

MOLECULAR FORMULA :: C6-H8-N2

MOLECULAR WEIGHT :: 108.16

WISWESSER LINE NOTATION :: ZR CZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 283 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 351 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 67700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 437 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 438 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 562 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1485 mg/kg/47W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 375 mg/kg

SEX/DURATION :: male 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 12 mg/L

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.1 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,111,1978 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,111,1978 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-SWITZERLAND:TWA 0.1 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83124 No. of Facilities: 1364 (estimated) No. of Industries: 18 No. of Occupations: 21 No. of Employees: 12590 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83124 No. of Facilities: 3739 (estimated) No. of Industries: 12 No. of Occupations: 18 No. of Employees: 40632 (estimated) No. of Female Employees: 32320 (estimated)

毒理学数据：: 1.急性毒性^[13] LD50：650mg/kg（大鼠经口）
2.刺激性^[14] 家兔经眼：100μl，重度刺激。
3.致突变性^[15] 微生物致突变性：鼠伤寒沙门菌10μg/皿。DNA抑制：小鼠经口200mg/kg。
4.致癌性^[16] IARC致癌性评论：G3，对人及动物致癌性证据不足。
5.其他^[17] 大鼠腹腔最低中毒剂量（TDLo）：375mg/kg（30d，雄性），引起胎死。

生态数据：

1.生态毒性^[18]

LC50：0.028mg/L（96h）（黑头呆鱼）；3.9mg/L（96h）（虹鳟鱼）；5.74mg/L（48h）（金鱼）

EC50：3.9mg/L（48h）（水蚤）

2.生物降解性^[19]

好氧生物降解（h）：168~672

厌氧生物降解（h）：672~2688

3.非生物降解性^[20]

水中光氧化半衰期（h）：31~1740

空气中光氧化半衰期（h）：0.278~2.78

间苯二胺 MSDS

国标编号:	61789
ＣＡＳ:	108-45-2
中文名称:	1，3-苯二胺
英文名称:	m-Phenylenediamine；1,3-diaminobenzene
别名:	间苯二胺；1，3-二氨基苯
分子式:	C₆H₈N₂；C₆H₄(NH₂)₂
分子量:	108.14
熔点:	63℃
密度:	相对密度(水=1)1.14；
蒸汽压:
溶解性:	溶于水、乙醇、乙醚
稳定性:	稳定
外观与性状:	无色针状结晶
危险标记:	15(毒害品)
用途:	用作染料中间体，环氧树脂的固化剂和水泥的促凝剂

2.对环境的影响: 一、健康危害侵入途径：吸入、食入、经皮吸收。健康危害：不易因吸入而中毒。如经口进入，则毒作用与苯胺同，由于形成高铁血红蛋白，使组织缺氧，出现紫绀，引起中枢神经系统，心血管系统等的损伤。二、毒理学资料及环境行为急性毒性：LD50650mg/kg(大鼠经口) 危险特性：遇明火、高热可燃。与强氧化剂可发生反应。受热分解放出有毒的氧化氮烟气。燃烧(分解)产物：一氧化碳、二氧化碳、氧化氮。 3.现场应急监测方法: 　 4.实验室监测方法: 盐酸萘乙二胺比色法《空气中有害物质的测定方法》(第二版)，杭士平主编 H-酸比色法《化工企业空气中有害物质测定方法》，化学工业出版社 5.环境标准: 美国车间卫生标准 0.1mg/m3[皮](1，4-苯二胺) 前苏联(1975) 水体中有害有机物的最大允许浓度 0.1mg/L(1，4-苯二胺) 6.应急处理处置方法: 一、泄漏应急处理隔离泄漏污染区，周围设警告标志，建议应急处理人员戴好防毒面具，穿化学防护服。不要直接接触泄漏物，用清洁的铲子收集于干燥净洁有盖的容器中，运至废物处理场所或用沙土混合，逐渐倒入稀盐酸中(1体积浓盐酸加2体积水稀释)，放置24小时，然后废弃。如大量泄漏，收集回收或无害处理后废弃。二、防护措施呼吸系统防护：空气中浓度较高时，佩带防毒面具。紧急事态抢救或逃生时，应该佩戴自给式呼吸器。眼睛防护：戴化学安全防护眼镜。防护服：穿紧袖工作服，长统胶鞋。手防护：戴橡皮手套。其它：工作现场禁止吸烟、进食和饮水。及时换洗工作服。工作前后不饮酒，用温水洗澡。进行就业前和定期的体检。三、急救措施皮肤接触：立即脱去污染的衣着，用肥皂水及清水彻底冲洗。注意手、足和指甲等部位。眼睛接触：立即提起眼睑，用大量流动清水或生理盐水冲洗。吸入：脱离现场至空气新鲜处。保持呼吸道通畅。必要时进行人工呼吸。就医。食入：误服者给漱口，饮水，洗胃后口服活性炭，再给以导泻。就医。灭火方法：雾状水、二氧化碳、砂土、干粉、泡沫。

间苯二胺

间苯二胺制备方法及用途

制备方法

合成制备方法

用途简介

用途

间苯二胺物化性质

间苯二胺安全信息

间苯二胺毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

间苯二胺 MSDS

间苯二胺分子结构与计算化学数据

分子结构数据

计算化学数据

间苯二胺上游产品

间苯二胺下游产品

间苯二胺表征图谱

推荐供应商

间苯二胺

间苯二胺 制备方法及用途

制备方法

合成制备方法

用途简介

用途

间苯二胺 物化性质

间苯二胺 安全信息

间苯二胺 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

间苯二胺 MSDS

间苯二胺 分子结构与计算化学数据

分子结构数据

计算化学数据

间苯二胺 上游产品

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间苯二胺 表征图谱

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间苯二胺制备方法及用途

间苯二胺物化性质

间苯二胺安全信息

间苯二胺毒理性

间苯二胺分子结构与计算化学数据

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