阿伯前列素
- 中文名称：
- 阿伯前列素
- 中文别名：
- 阿伯前列素;
阿巴前列素
- 英文名称：
- Prosta-5,13-dien-1-oicacid, 11,15-dihydroxy-15-methyl-9-oxo-, (5Z,11a,13E,15R)-
- 英文别名：
- 15(R)-15-methyl Prostaglandin E2;
CU-83;
9-OXO-11ALPHA,15R-DIHYDROXY-15-METHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID;
,15r);
ARBAPROSTIL
- CAS No.：
- 55028-70-1
- 分 子 式：
-
C21H34O5
- 分 子 量：
- 366.55
- 精确分子量：
- 366.24100
- PSA：
- 94.83000
- InChI：
- The Key: XSGQFHNPNWBVPT-XFRNOMTPSA-N3
- 安全术语：
- Human reproductive effects by intramuscular route: terminates pregnancy. Other experimental reproductive effects.
- 分子结构式：
-
- SDS：
- 查看
阿伯前列素 物化性质
- 密度：
- 1.134g/cm3
- 沸点：
- 535.5ºC at 760 mmHg
- 闪点：
- 291.7ºC
- 折射率：
- 1.556
- 存储条件/存储方法：
- 库房通风低温干燥
阿伯前列素 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UK7895000
- CHEMICAL NAME :
- Prosta-5,13-dien-1-oic acid,
11,15-dihydroxy-15-methyl-9-oxo-,
(5Z,11-alpha,13E,15R)-
- CAS REGISTRY NUMBER :
- 55028-70-1
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C21-H34-O5
- MOLECULAR WEIGHT :
- 366.55
- WISWESSER LINE NOTATION :
- L5VTJ B2U4VQ C1U1XQ5&1 DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 600 ng/kg
- SEX/DURATION :
- female 12 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - abortion
- REFERENCE :
- CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 9,523,1974
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2800 ug/kg
- SEX/DURATION :
- female 15-22 day(s) after conception
lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 21,62A,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 84 mg/kg
- SEX/DURATION :
- male 63 day(s) pre-mating
female 14 day(s) pre-mating - 7 day(s) after
conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16(Suppl 4),S949,1988
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 22 mg/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - abortion
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Newborn - live birth index (measured after birth)
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16(Suppl 4),S957,1988
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1400 ug/kg
- SEX/DURATION :
- female 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 21,71A,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 10400 ug/kg
- SEX/DURATION :
- female 17 ? after conception - 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - live birth index (measured after birth)
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16(Suppl 4),S981,1988
*** REVIEWS ***
TOXICOLOGY REVIEW
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 113,130,1972
