赛洛西宾
- 中文名称：
- 赛洛西宾
- 中文别名：
-
- 英文名称：
- 1H-Indol-4-ol,3-[2-(dimethylamino)ethyl]-, 4-(dihydrogen phosphate)
- 英文别名：
- psilocybin;
[3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate;
Psilocybine;
Psilotsibin;
Teonanacatl;
Indocybin;
CY-39;
Psilocybin;
Psilocibin;
Psilocybinum;
Psilocin phosphate ester
- CAS No.：
- 520-52-5
- 分 子 式：
-
C12H17N2O4P
- 分 子 量：
- 284.28
- 精确分子量：
- 284.09300
- PSA：
- 95.60000
- EINECS：
- 208-294-4
- InChI：
- The Key: QVDSEJDULKLHCG-UHFFFAOYSA-N3
- 安全术语：
- Poison by intravenous route. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion and intraperitoneal routes: euphoria, hallucinations, toxic psychosis, muscle weakness, nausea or vomiting, visual field changes. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and POx.
- 分子结构式：
-
- SDS：
- 查看
赛洛西宾 物化性质
- 密度：
- 1.409g/cm3
- 熔点：
- 220-228ºC
- 沸点：
- 523.4ºC at 760mmHg
- 闪点：
- 270.4ºC
- 折射率：
- 1.644
- 存储条件/存储方法：
- 库房低温,通风,干燥
赛洛西宾 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NM3150000
- CHEMICAL NAME :
- Indol-4-ol, 3-(2-(dimethylamino)ethyl)-, dihydrogen
phosphate
- CAS REGISTRY NUMBER :
- 520-52-5
- BEILSTEIN REFERENCE NO. :
- 0273158
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C12-H17-N2-O4-P
- MOLECULAR WEIGHT :
- 284.28
- WISWESSER LINE NOTATION :
- T56 BMJ D2N1&1 FOPQQO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 75 ug/kg
- TOXIC EFFECTS :
- Behavioral - euphoria
Behavioral - hallucinations, distorted perceptions
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 60 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - visual field changes
Behavioral - muscle weakness
Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 37 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - visual field changes
Behavioral - muscle weakness
Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 130 ug/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions
Behavioral - toxic psychosis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 420 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 275 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 13 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TEST SYSTEM :
- Human
- DOSE/DURATION :
- 229 ug/kg
- REFERENCE :
- HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For
publisher information, see HUGEDQ. Volume(issue)/page/year: 9,281,1970
*** REVIEWS ***
TOXICOLOGY REVIEW
JMTHBU Journal of the Medical Association of Thailand. (Businesss Mgr.,
Dept. of Microbiology, Faculty of Medicine, Siriraj Hospital, Bangkok 7,
Thailand) V.1- 1918- Volume(issue)/page/year: 58,623,1975
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7177
No. of Facilities: 25 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 1358 (estimated)
No. of Female Employees: 956 (estimated)
