维洛沙秦
- 中文名称：
- 维洛沙秦
- 中文别名：
- 维洛沙秦;
2-((2-乙氧基苯氧基)甲基)吗啉
- 英文名称：
- Morpholine,2-[(2-ethoxyphenoxy)methyl]-
- 英文别名：
- 2-[(2-ethoxyphenoxy)methyl]morpholine;
Emovit;
Morpholine,2-((2-ethoxyphenoxy)methyl);
Viloxazinum [INN-Latin];
2-(2-Ethoxy-phenoxymethyl)-morpholine;
2-(o-ethoxyphenoxymethyl)morpholine;
viloxazine;
Viloxazina [INN-Spanish];
Viloxazin
- CAS No.：
- 46817-91-8
- 分 子 式：
-
C13H19NO3
- 分 子 量：
- 237.33
- 精确分子量：
- 237.13600
- PSA：
- 39.72000
- EINECS：
- 256-281-7
- InChI：
- The Key: YWPHCCPCQOJSGZ-UHFFFAOYSA-N3
- 安全术语：
- Poison by intravenous route. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also VILOXAZINE HYDROCHLORIDE.
- 分子结构式：
-
- SDS：
- 查看
维洛沙秦 物化性质
- 密度：
- 1.061 g/cm3
- 熔点：
- 185-186ºC
- 沸点：
- 350.5ºC at 760 mmHg
- 闪点：
- 144.3ºC
- 折射率：
- 1.499
维洛沙秦 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QE3940000
- CHEMICAL NAME :
- Morpholine, 2-((2-ethoxyphenoxy)methyl)-
- CAS REGISTRY NUMBER :
- 46817-91-8
- LAST UPDATED :
- 199403
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C13-H19-N-O3
- MOLECULAR WEIGHT :
- 237.33
- WISWESSER LINE NOTATION :
- T6M DOTJ C1OR BO2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
- REFERENCE :
- HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag,
Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978-
Volume(issue)/page/year: 55,527,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
- REFERENCE :
- HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag,
Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978-
Volume(issue)/page/year: 55,527,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 552 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
V.9- 1974- Volume(issue)/page/year: 27,437,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
- REFERENCE :
- HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag,
Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978-
Volume(issue)/page/year: 55,527,1980
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 130 mg/kg
- SEX/DURATION :
- female 8-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
Volume(issue)/page/year: 7,504,1984
