甘露醇氮芥
- 中文名称：
- 甘露醇氮芥
- 中文别名：
- 甘露醇氮芥
- 英文名称：
- D-Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride (9CI)
- 英文别名：
- (2R,3R,4R,5R)-1,6-bis(2-chloroethylamino)hexane-2,3,4,5-tetrol,dihydrochloride;
1,6-Bis(chloroethylamino)-1,6-desoxymannitol dihydrochloride;
Mannitol,1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-,dihydrochloride,D;
Degranol;
Degranol chinoin;
Mannomustine dihydrochloride;
D-Mannitol,1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-,dihydrochloride;
1,6-Dideoxy-1,6-di(2-chloroethylamino)-D-mannitol dihydrochloride
- CAS No.：
- 551-74-6
- 分 子 式：
-
C10H22Cl2N2O4.2ClH
- 分 子 量：
- 378.13
- 精确分子量：
- 376.04900
- PSA：
- 104.98000
- InChI：
- The Key: KGOHSLTUIYXWMS-WFFMJNDQSA-N3
- 安全术语：
- Poison by intravenous, subcutaneous, and parenteral routes. Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Human mutation data reported. A drug used for the treatment of malignant neoplasms. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also MANNOMUSTINE.
- 分子结构式：
-
- SDS：
- 查看
甘露醇氮芥 物化性质
- 沸点：
- 541.9ºC at 760 mmHg
- 闪点：
- 281.5ºC
- 蒸汽压：
- 5.27E-14mmHg at 25°C
甘露醇氮芥 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OP2275000
- CHEMICAL NAME :
- Mannitol, 1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-,
dihydrochloride, D-
- CAS REGISTRY NUMBER :
- 551-74-6
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 21
- MOLECULAR FORMULA :
- C10-H22-Cl2-N2-O4.2Cl-H
- MOLECULAR WEIGHT :
- 378.16
- WISWESSER LINE NOTATION :
- G2M1YQYQYQYQ1M2G &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 7600 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
Blood - leukopenia
Blood - thrombocytopenia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Blood - leukopenia
Blood - thrombocytopenia
Blood - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 260 mg/kg/4D-I
- TOXIC EFFECTS :
- Liver - other changes
Blood - changes in spleen
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 23 mg/kg/4W
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7265 ug/kg/4W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 50 mg/kg
- SEX/DURATION :
- female 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
- TYPE OF TEST :
- DNA damage
MUTATION DATA
- TYPE OF TEST :
- Host-mediated assay
- TEST SYSTEM :
- Rodent - mouse Bacteria - Escherichia coli
- DOSE/DURATION :
- 1 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 21,190,1973
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,157,1975
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,157,1975
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
