巴龙霉素
- 中文名称：
- 巴龙霉素
- 中文别名：
- 巴龙霉素
- 英文名称：
- paromomycin
- 英文别名：
- paromomycin;
paramomycin;
2-Propanol,1-[(1-methylethyl)amino]-3-[4-(2-propenyloxy)phenoxy];
para-Oxprenolol;
par0momycin
- CAS No.：
- 7542-37-2
- 分 子 式：
-
C23H45N5O14
- 分 子 量：
- 615.62800
- 精确分子量：
- 615.29600
- PSA：
- 347.32000
- InChI：
- The Key: UOZODPSAJZTQNH-ZEUOIICNSA-N3
- SDS：
- 查看
巴龙霉素 物化性质
- 密度：
- 1.64g/cm3
- 沸点：
- 939.8ºC at 760 mmHg
- 闪点：
- 522.2ºC
- 折射率：
- 1.676
巴龙霉素 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WK2315000
- CHEMICAL NAME :
- Streptamine,
O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-O
-beta-D-ribofuranosyl-
(1-5)-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl-(1-4)
)-2-deoxy-
- CAS REGISTRY NUMBER :
- 7542-37-2
- BEILSTEIN REFERENCE NO. :
- 0072285
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C23-H45-N5-O14
- MOLECULAR WEIGHT :
- 615.73
- WISWESSER LINE NOTATION :
- T6OTJ B1Z CQ DQ EZ FO- CT5OTJ B1Q DQ EO- CL6TJ AZ BQ
EZ DO- BT6OTJ CZ DQ EQ F1Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21620 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
Skin and Appendages - hair
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
16,124,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1010 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 12,243,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 156 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PRMEAI Presse Medicale. (Paris, France) V.1-79n.55, 1893-1971. For
publisher information, see NPMDAD Volume(issue)/page/year: 70,127,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Behavioral - rigidity (including catalepsy)
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - hair
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
16,124,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2275 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
eds., Washington, DC, American Soc. for Microbiology, 1978
Volume(issue)/page/year: 1,674,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 930 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds.,
Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,332,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 423 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PRMEAI Presse Medicale. (Paris, France) V.1-79n.55, 1893-1971. For
publisher information, see NPMDAD Volume(issue)/page/year: 70,127,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PRMEAI Presse Medicale. (Paris, France) V.1-79n.55, 1893-1971. For
publisher information, see NPMDAD Volume(issue)/page/year: 70,127,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
16,124,1968
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 324 gm/kg/30D-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
16,124,1968
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18 gm/kg/30D-I
- TOXIC EFFECTS :
- Liver - other changes
Kidney, Ureter, Bladder - other changes
Related to Chronic Data - death
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
16,124,1968
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 27300 mg/kg/13W-I
- TOXIC EFFECTS :
- Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
16,124,1968
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 7500 mg/kg/30D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - normocytic anemia
Blood - changes in bone marrow (not otherwise specified)
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
16,124,1968
*** REVIEWS ***
TOXICOLOGY REVIEW
ADCMAZ Advances in Chemotherapy. (New York, NY) V.1-3, 1964-68. For
publisher information, see AVPCAQ. Volume(issue)/page/year: 3,39,1968
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