制备方法

熔融连续法将理论量的氟化钠和六偏磷酸钠充分混合均匀,连续加入石墨衬里的反应器中,加热熔融,不断流出的物料经冷却(风冷)制得单氟磷酸钠成品。其6NaF+(NaPO3)6→6Na2PO3F

合成制备方法

1.熔融连续法

用途简介

代替氟化钠在牙膏配方中用作防龋剂、牙齿脱敏剂,也用于清洁金属表面和作熔剂,还可用于制造特种玻璃

用途

1.代替氟化钠在牙膏配方中用作防龋剂、牙齿脱敏剂，也用于清洁金属表面和用作熔剂，还可用于制造特种玻璃；代替氟化钠在牙膏配方中用作防龋剂、牙齿脱敏剂，也用于清洁金属表面和作熔剂，还可用于制造特种玻璃；用作实验试剂。

2.用作防龋剂、牙齿脱敏剂，在牙膏配方中，一般占0.7%～0.76％，目前国外已基本取代了氟化钠，并在与氟化亚锡的竞争中取得了优势。也用于清洁金属表面和作熔剂，还用于制造特种玻璃。也用于杀菌剂、防腐剂。

包装等级：

III

风险类别：

6.1

海关代码：

2835299000

WGK_Germany：

3
德国有关水污染物质的分类清单

危险类别码：

R22

安全说明：

S22-S24/25

RTECS号：

TE6130000

危险标志：

Xn

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TE6130000

CHEMICAL NAME :

Phosphorofluoridic acid, disodium salt

CAS REGISTRY NUMBER :

10163-15-2

LAST UPDATED :

199510

DATA ITEMS CITED :

13

MOLECULAR FORMULA :

F-O3-P.2Na

MOLECULAR WEIGHT :

143.95

WISWESSER LINE NOTATION :

.NA2.P-F-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

570 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

220 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

710 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :

Insect - Drosophila melanogaster

REFERENCE :

GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264) V.1- 1916- Volume(issue)/page/year: 87,67,1977 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,237,1982 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,237,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,208,1987 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Gen Indu):8H TWA 2.5 mg(F)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2.5 mg(F)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2.5 mg(F)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 2.5 mg(F)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO FLUORIDES, INORGANIC-air:10H TWA 2.5 mg(F)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2356 No. of Facilities: 44 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 16999 (estimated) No. of Female Employees: 15598 (estimated)

毒理学数据：

在皮肤和粘膜上造成腐蚀影响，刺激皮肤和粘膜。

生态数据：

通常对水是不危害的，若无政府许可，勿将材料排入周围环境。

分子结构数据

1、摩尔折射率：无可用的

2、摩尔体积（cm³/mol）：无可用的

3、等张比容（90.2K）：无可用的

4、表面张力（dyne/cm）：无可用的

5、介电常数：无可用的

6、极化率（10^-24cm³）：无可用的

7、单一同位素质量：143.936448 Da

8、标称质量：144 Da

9、平均质量：143.9499 Da

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:4

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积63.2

7.重原子数量:7

8.表面电荷:0

9.复杂度:49.8

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:3