4,4'-亚甲基二-苯胺盐酸盐(1:2)
- 中文名称：
- 4,4'-亚甲基二-苯胺盐酸盐(1:2)
- 中文别名：
-
- 英文名称：
- Benzenamine,4,4'-methylenebis-, hydrochloride (1:2)
- 英文别名：
- 4-[(4-aminophenyl)methyl]aniline,dihydrochloride;
bis(4-aminophenyl)methane dihydrochloride;
METHYLENEDIANILINE DIHYDROCHLORIDE;
EINECS 236-934-2;
4,4'-Methylenedianiline dihydrochloride;
4,4'-diaminodiphenylmethane dihydrochloride;
4,4'-Methylenedianilinium dichloride;
4,4'-Methylenebisbenzenamine dihydrochloride;
p,p'-Methylenedianiline dihydrochloride;
4,4'-Methylenedianiline.2HCl
- CAS No.：
- 13552-44-8
- 分 子 式：
-
C13H14N2.2ClH
- 分 子 量：
- 271.21
- 精确分子量：
- 270.06900
- PSA：
- 52.04000
- EINECS：
- 236-934-2
- InChI：
- The Key: NORZRJZMVPBSIJ-UHFFFAOYSA-N3
- 安全术语：
- Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and HCl. See also ANILINE DYES.
- 分子结构式：
-
- SDS：
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4,4'-亚甲基二-苯胺盐酸盐(1:2) 物化性质
- 密度：
- 1.143g/cm3
- 熔点：
- 92.5ºC
- 沸点：
- 398ºC at 760mmHg
- 闪点：
- 226.3ºC
- 蒸汽压：
- 1.52E-06mmHg at 25°C
4,4'-亚甲基二-苯胺盐酸盐(1:2) 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BY5426000
- CHEMICAL NAME :
- Aniline, 4,4'-methylenedi-, dihydrochloride
- CAS REGISTRY NUMBER :
- 13552-44-8
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C13-H14-N2.2Cl-H
- MOLECULAR WEIGHT :
- 271.21
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7280 mg/kg/13W-C
- TOXIC EFFECTS :
- Liver - other changes
Endocrine - thyroid weight (goiter)
Endocrine - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2240 mg/kg/14D-C
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10950 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 21900 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Endocrine - adrenal cortex tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21900 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Endocrine - thyroid tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 43800 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Endocrine - thyroid tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21630 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Endocrine - thyroid tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10815 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 21630 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 500 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
13,133,1989
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 39,347,1986
4,4'-亚甲基二-苯胺盐酸盐(1:2) 上游产品
