3-alpha-[(4-氯苯基)苯基甲氧基]莨菪烷盐酸盐
- 中文名称：
- 3-alpha-[(4-氯苯基)苯基甲氧基]莨菪烷盐酸盐
- 中文别名：
-
- 英文名称：
- 8-Azabicyclo[3.2.1]octane,3-[(4-chlorophenyl)phenylmethoxy]-8-methyl-, hydrochloride (1:1), (3-endo)-
- 英文别名：
- 3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane,hydrochloride;
Clobenztropin-hydrochlorid;
Chlortropbenzyl;
Desipramine hydrochloride;
WY 2149;
SL-6057;
FC-1;
3-CPMT;
Tropine 4-chlorobenzhydryl ether hydrochloride
- CAS No.：
- 14008-79-8
- 分 子 式：
-
C21H24ClNO.ClH
- 分 子 量：
- 378.37
- 精确分子量：
- 377.13100
- PSA：
- 12.47000
- InChI：
- The Key: FXKCQWIUITUJFU-UHEBOZJGSA-N3
- 危险品标志：
- 风险术语：
- 22
- 安全术语：
- Poison by ingestion, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and HCl.
- 分子结构式：
-
- SDS：
- 查看
3-alpha-[(4-氯苯基)苯基甲氧基]莨菪烷盐酸盐 物化性质
- 沸点：
- 437.2ºC at 760mmHg
- 闪点：
- 218.2ºC
- 蒸汽压：
- 7.62E-08mmHg at 25°C
3-alpha-[(4-氯苯基)苯基甲氧基]莨菪烷盐酸盐 安全信息
- WGK_Germany：
- 3
德国有关水污染物质的分类清单
- 危险类别码：
- R22
- 安全说明：
- S26
- 危险标志：
- Xn: Harmful;
3-alpha-[(4-氯苯基)苯基甲氧基]莨菪烷盐酸盐 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YM3055500
- CHEMICAL NAME :
- 1-alpha-H,5-alpha-H-Tropane,
3-alpha-((p-chloro-alpha-phenylbenzyl)oxy)-,
hydrochloride
- CAS REGISTRY NUMBER :
- 14008-79-8
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C21-H24-Cl-N-O.Cl-H
- MOLECULAR WEIGHT :
- 378.37
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 364 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - muscle weakness
Behavioral - ataxia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 114,192,1955
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 58 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - muscle weakness
Behavioral - ataxia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 114,192,1955
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 174 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - muscle weakness
Behavioral - ataxia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 114,192,1955
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - muscle weakness
Behavioral - ataxia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 114,192,1955
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 114,192,1955
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3120 mg/kg/26W-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 114,192,1955
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1560 mg/kg/26W-I
- TOXIC EFFECTS :
- Behavioral - muscle weakness
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Related to Chronic Data - death
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 114,192,1955
3-alpha-[(4-氯苯基)苯基甲氧基]莨菪烷盐酸盐 上游产品
