1,2,3,3a,3b,4,5,5a,6,7,10,10a,10b,11,12,12a-十六氢-1,10a,12a-三甲基-环戊二烯并(7,8)菲并(2,3-c)吡唑-1-醇
- 中文名称：
- 1,2,3,3a,3b,4,5,5a,6,7,10,10a,10b,11,12,12a-十六氢-1,10a,12a-三甲基-环戊二烯并(7,8)菲并(2,3-c)吡唑-1-醇
- 中文别名：
-
- 英文名称：
- 2'H-Androst-2-eno[3,2-c]pyrazol-17-ol,17-methyl-, (5a,17b)-
- 英文别名：
- Cyclopenta[7,8]phenanthro-[2,3-c]pyrazol-1-ol, 1,2,3,3a,3b,4,5,5a,6,8,10,10a,10b,11,12,12a-hexadecahydro-1,10a,12a-trimethyl-;
1H-Androstano3,2-cpyrazol-17-ol, 17-methyl-, (5.alpha.,17.beta.)-
- CAS No.：
- 302-96-5
- 分 子 式：
-
C21H32N2O
- 分 子 量：
- 328.55
- 精确分子量：
- 328.25100
- PSA：
- 48.91000
- InChI：
- The Key: LKAJKIOFIWVMDJ-OLPJAUBDSA-N3
- 安全术语：
- Human systemic effects by ingestion: jaundice. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
- 分子结构式：
-
- SDS：
- 查看
1,2,3,3a,3b,4,5,5a,6,7,10,10a,10b,11,12,12a-十六氢-1,10a,12a-三甲基-环戊二烯并(7,8)菲并(2,3-c)吡唑-1-醇 物化性质
- 密度：
- 1.129g/cm3
- 熔点：
- 229.8-242.0ºC
- 沸点：
- 490.8ºC at 760mmHg
- 闪点：
- 250.7ºC
1,2,3,3a,3b,4,5,5a,6,7,10,10a,10b,11,12,12a-十六氢-1,10a,12a-三甲基-环戊二烯并(7,8)菲并(2,3-c)吡唑-1-醇 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BV8077000
- CHEMICAL NAME :
- 1'H-Androstano(3,2-c)pyrazol-17-ol, 17-methyl-,
(5-alpha,17-beta)-
- CAS REGISTRY NUMBER :
- 302-96-5
- LAST UPDATED :
- 199103
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C21-H32-N2-O
- MOLECULAR WEIGHT :
- 328.55
- WISWESSER LINE NOTATION :
- T G5 E6 B665 HNN HUTJ M1 Q1 RQ R1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 24 mg/kg/17W-I
- TOXIC EFFECTS :
- Liver - jaundice, other or unclassified
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
294,612,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 4285 mg/kg/30D-I
- TOXIC EFFECTS :
- Liver - jaundice, other or unclassified
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
294,612,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,375,1982
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 4800 ug/kg
- SEX/DURATION :
- female 13-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 4,2088,1970
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3 gm/kg
- SEX/DURATION :
- female 13-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - homeostasis
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 4,2088,1970
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 14 mg/kg
- SEX/DURATION :
- female 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Fertility - other measures of fertility
- REFERENCE :
- CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 5,489,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 36 mg/kg
- SEX/DURATION :
- female 12 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - menstrual cycle changes or disorders
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA,
1255 Howard St., San Francisco, CA 94103) V.6- 1958-
Volume(issue)/page/year: 14,285,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 1100 ug/kg
- SEX/DURATION :
- male 2 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - other effects on male
Endocrine - androgenic
- REFERENCE :
- THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
V.1- 1974- Volume(issue)/page/year: 28,109,1987
