丙吗卡因
- 中文名称：
- 丙吗卡因
- 中文别名：
- 丙吗卡因
- 英文名称：
- Morpholine,4-[3-(4-butoxyphenoxy)propyl]-
- 英文别名：
- pramocaine;
pramocainum;
Tronopthane;
Proxazocain;
Tronothane;
4-[3-(4-butoxyphenoxy)propyl]morpholine;
Pramocaine;
pramoxine
- CAS No.：
- 140-65-8
- 分 子 式：
-
C17H27NO3
- 分 子 量：
- 293.4012
- 精确分子量：
- 293.19900
- PSA：
- 30.93000
- InChI：
- The Key: DQKXQSGTHWVTAD-UHFFFAOYSA-N3
- 分子结构式：
-
- SDS：
- 查看
丙吗卡因 物化性质
- 密度：
- 1.031g/cm3
- 沸点：
- 427ºC at 760 mmHg
- 闪点：
- 123.5ºC
- 折射率：
- 1.505
- 蒸汽压：
- 1.7E-07mmHg at 25°C
丙吗卡因 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QD8575000
- CHEMICAL NAME :
- Morpholine, 4-(3-(p-butoxyphenoxy)propyl)-
- CAS REGISTRY NUMBER :
- 140-65-8
- BEILSTEIN REFERENCE NO. :
- 0239059
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C17-H27-N-O3
- MOLECULAR WEIGHT :
- 293.45
- WISWESSER LINE NOTATION :
- T6N DOTJ A3OR DO4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co.,
Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957-
Volume(issue)/page/year: 38,265,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co.,
Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957-
Volume(issue)/page/year: 38,265,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 79 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
V.9- 1974- Volume(issue)/page/year: 10,291,1975
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9141
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 153 (estimated)
No. of Female Employees: 150 (estimated)
丙吗卡因 海关数据
中国海关编码：2934999090
- 概述：
- 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途
- 摘要/Summary：
- 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
丙吗卡因 分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值（XlogP）:3.1
2.氢键供体数量:0
3.氢键受体数量:4
4.可旋转化学键数量:9
5.互变异构体数量:无
6.拓扑分子极性表面积:30.9
7.重原子数量:21
8.表面电荷:0
9.复杂度:248
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
