甲磺酸伊马替尼
- 中文名称：
- 甲磺酸伊马替尼
- 中文别名：
- 磺胺吡啶钠盐
- 英文名称：
- Benzenesulfonamide,4-amino-N-2-pyridinyl-, sodium salt (1:1)
- 英文别名：
- sodium,(4-aminophenyl)sulfonyl-pyridin-2-ylazanide;
Sodium sulfapymonohydrate;
Sulfanilsaeure-[2]pyridylamid,Natrium-Salz;
Soluble sulfapyridine;
EINECS 204-850-5;
Sodium sulphapyridine;
n1-2-pyridylsulfanilamide sodium salt;
Sulfapyridine sodium salt monohydrate;
Sulfapyridine,sodium salt;
sodium salt of sulfanilic acid 2-pyridylamide;
sulfanilic acid-[2]pyridylamide,sodium-salt;
Sulfapyridine sodium;
Sodium sulfapyridine;
Soludagenan;
Sulfanylsaeure-(2-pyridylamid)
- CAS No.：
- 127-57-1
- 分 子 式：
-
C11H11N3O2S.Na
- 分 子 量：
- 271.27100
- 精确分子量：
- 271.03900
- PSA：
- 81.43000
- InChI：
- The Key: DAINBAXHBFSNCQ-UHFFFAOYSA-N3
- 分子结构式：
-
- SDS：
- 查看
甲磺酸伊马替尼 物化性质
- 沸点：
- 473.5ºC at 760 mmHg
- 闪点：
- 240.2ºC
- 蒸汽压：
- 3.9E-09mmHg at 25°C
甲磺酸伊马替尼 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WD7175000
- CHEMICAL NAME :
- Sodium, (N(sup 1)-2-pyridylsulfanilamido)-
- CAS REGISTRY NUMBER :
- 127-57-1
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C11-H10-N3-O2-S.Na
- MOLECULAR WEIGHT :
- 271.29
- WISWESSER LINE NOTATION :
- T6NJ BMSWR DZ &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2994 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIDXA3 Journal of the Indiana State Medical Association. (Indiana State
Medical Assoc., 3935 N. Meridian, Indianapolis, IN 46208) V.1- 1908-
Volume(issue)/page/year: 33,503,1940
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 45,15,1940
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 648 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 33,80,1944
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 68,259,1940
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 910 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIDXA3 Journal of the Indiana State Medical Association. (Indiana State
Medical Assoc., 3935 N. Meridian, Indianapolis, IN 46208) V.1- 1908-
Volume(issue)/page/year: 33,503,1940
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 872 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 71,138,1941
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 696 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIDXA3 Journal of the Indiana State Medical Association. (Indiana State
Medical Assoc., 3935 N. Meridian, Indianapolis, IN 46208) V.1- 1908-
Volume(issue)/page/year: 33,503,1940
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1096 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIDXA3 Journal of the Indiana State Medical Association. (Indiana State
Medical Assoc., 3935 N. Meridian, Indianapolis, IN 46208) V.1- 1908-
Volume(issue)/page/year: 33,503,1940
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 43,328,1940
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIDXA3 Journal of the Indiana State Medical Association. (Indiana State
Medical Assoc., 3935 N. Meridian, Indianapolis, IN 46208) V.1- 1908-
Volume(issue)/page/year: 33,503,1940
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 693 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIDXA3 Journal of the Indiana State Medical Association. (Indiana State
Medical Assoc., 3935 N. Meridian, Indianapolis, IN 46208) V.1- 1908-
Volume(issue)/page/year: 33,503,1940
甲磺酸伊马替尼 海关数据
中国海关编码：2933990090
- 概述：
- 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- 摘要/Summary：
- 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
