1-[3-(对氟苯甲酰基)丙基]-4-甲基哌嗪氯化物
- 中文名称：
- 1-[3-(对氟苯甲酰基)丙基]-4-甲基哌嗪氯化物
- 中文别名：
- 1-[3-(对氟苯甲酰基)丙基]-4-甲基哌嗪氯化物;
盐酸美哌隆
- 英文名称：
- 1-Butanone,1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-, hydrochloride (1:1)
- 英文别名：
- 1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one,hydrochloride;
8-pCPT-2-O-Me-cAMP-AM;
Melperone hydrochloride;
Metylperon;
1-[3-(p-fluorobenzoyl)propyl]-4-methylpiperazinium chloride
- CAS No.：
- 1622-79-3
- 分 子 式：
-
C16H22FNO.ClH
- 分 子 量：
- 299.85
- 精确分子量：
- 299.14500
- PSA：
- 20.31000
- EINECS：
- 216-599-9
- 安全术语：
- Poison by ingestion, subcutaneous, and intravenous routes. Experimental teratogenic effects. A neuroleptic drug used to treat anxiety and confusion. When heated to decomposition it emits very toxic fumes of F−, NOx, and HCl.
- 分子结构式：
-
- SDS：
- 查看
1-[3-(对氟苯甲酰基)丙基]-4-甲基哌嗪氯化物 物化性质
- 熔点：
- 209-211ºC
- 沸点：
- 376.1ºC at 760mmHg
- 闪点：
- 181.3ºC
- 蒸汽压：
- 6.9E-06mmHg at 25°C
1-[3-(对氟苯甲酰基)丙基]-4-甲基哌嗪氯化物 安全信息
1-[3-(对氟苯甲酰基)丙基]-4-甲基哌嗪氯化物 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EU4025000
- CHEMICAL NAME :
- Butyrophenone, 4'-fluoro-4-(4-methylpiperidino)-,
hydrochloride
- CAS REGISTRY NUMBER :
- 1622-79-3
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C16-H22-F-N-O.Cl-H
- MOLECULAR WEIGHT :
- 299.85
- WISWESSER LINE NOTATION :
- T6NTJ A3VR DF& D1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 330 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
23,109,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 220 mg/kg
- TOXIC EFFECTS :
- Vascular - BP elevation not characterized in autonomic section
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
23,109,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - body temperature decrease
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
23,109,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 230 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
23,109,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 230 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,191,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
23,109,1965
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3640 mg/kg/13W-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
19,127,1971
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7280 mg/kg/26W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
- REFERENCE :
- FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy)
V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 29,586,1974
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 8120 mg/kg/13W-C
- TOXIC EFFECTS :
- Related to Chronic Data - death
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
19,127,1971
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 14560 mg/kg/26W-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Related to Chronic Data - death
- REFERENCE :
- FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy)
V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 29,586,1974
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 195 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- REFERENCE :
- FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy)
V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 29,586,1974
1-[3-(对氟苯甲酰基)丙基]-4-甲基哌嗪氯化物 海关数据
中国海关编码：2933399090
- 概述：
- 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- 摘要/Summary：
- 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
