二溴磷,300-76-5，生产厂家，价格-洛克化工网移动版

返回



基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

海关数据

结构与计算化学

表征图谱

二溴磷

中文名称：: 二溴磷

中文别名：: 二溴磷;
万丰灵;
O,O'-二甲基-1,2-二溴-2,2-二氯乙基磷酸盐;
1,2-二溴-2,2,-二氯乙基二甲基磷酸酯;
二溴敌敌畏;
1,2-二溴-2,2-二氯乙基二甲基磷酸酯

英文名称：: Phosphoric acid,1,2-dibromo-2,2-dichloroethyl dimethyl ester

英文别名：: naled;
Fosbrom;
Dibromfos;
phosphoric acid 1,2-dibromo-2,2-dichloro-ethyl ester dimethyl ester;
dibrom;
1,2-dibromo-2,2-dichloro-ethyl dimethyl phosphate;
rac-(1R)-1,2-dibromo-2,2-dichloroethyl dimethyl phosphate;
(1,2-Dibromo-2,2-dichloroethyl) dimethyl phosphate,Bromchlophos,Naled;
Orthodibromo;
Bromex;
Dibrom;
(1,2-dibromo-2,2-dichloroethyl) dimethyl phosphate;
(RS)-1,2-dibromo-2,2-dichloroethyl dimethyl phosphate;
BRP;
1,2-dibromo-2,2-dichloroethyl dimethyl phosphate;
Arthodibrom;
Bromchlophos;
Ortho-Dibrom;
fosforan;
bromchlophos

CAS No.：: 300-76-5

分子式：: C₄H₇Br₂Cl₂O₄P

分子量：: 380.80

精确分子量：: 377.78300

PSA：: 54.57000

MDL：: MFCD00053227

EINECS：: 206-098-3

BRN：: 2049930

InChI：: InChI=1/C4H7Br2Cl2O4P/c1-10-13(9,11-2)12-3(5)4(6,7)8/h3H,1-2H33

危险品标志：: XnN

风险术语：: R21/22;R36/38;R50;

安全术语：: S36/37;S61;

分子结构式：

SDS：: 查看

二溴磷毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TB9450000

CHEMICAL NAME :: Phosphoric acid, 1,2-dibromo-2,2-dichloroethyl dimethyl ester

CAS REGISTRY NUMBER :: 300-76-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 43

MOLECULAR FORMULA :: C4-H7-Br2-Cl2-O4-P

MOLECULAR WEIGHT :: 380.80

WISWESSER LINE NOTATION :: GXGEYEOPO&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human - man

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 92 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 222 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1500 mg/m3/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 52 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1350 mg/kg/9W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - body temperature decrease Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Bacillus subtilis

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 29,268,1981 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 3 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 3 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,73,1971 OSHA PEL (Gen Indu):8H TWA 3 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 3 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 3 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 3 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 3 mg/m3;Skin JAN 1993 OEL-AUSTRIA:TWA 3 mg/m3 JAN 1993 OEL-BELGIUM:TWA 3 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 3 mg/m3 JAN 1993 OEL-FINLAND:TWA 3 mg/m3;STEL 6 mg/m3 JAN 1993 OEL-FRANCE:TWA 3 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 3 mg/m3;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 3 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 3 mg/m3 JAN 1993 OEL-THAILAND:TWA 3 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 3 mg/m3;STEL 6 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO THE CHEMICAL-air:10H TWA 3 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 26420 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 16 (estimated)

毒理学数据：

1.急性毒性^[9]

LD50：430mg/kg（大鼠经口）；1100mg/kg（兔经皮）

2.刺激性^[10] 家兔经皮：500mg（24h），重度刺激。

3.亚急性与慢性毒性^[11] 连续给兔皮下注射乳剂1月，0.1LD50引起重度中毒，ChE活性显著下降，死亡率达60%。

4.致突变性^[12] 微生物致突变：鼠伤寒沙门菌50μg/皿。微生物致突变：枯草菌50μg/皿。

生态数据：

1.生态毒性^[13]

LC50：0.127mg/L（96h）（山鳟，静态）；0.132mg/L（96h）（虹鳟鱼）；3.3mg/L（96h）（黑头呆鱼，静态）；0.18mg/L（96h）（蓝鳃太阳鱼）

EC50：0.3ppb（48h）（水蚤，静态）；1.5ppb（48h）（水蚤，动态）

2.生物降解性 暂无资料

3.非生物降解性^[14] 空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期为2.5d（理论）。

二溴磷 MSDS

国标编号:	61874
ＣＡＳ:	300-76-5
中文名称:	二溴磷
英文名称:	Dibrom
别名:	二溴灵；二溴敌敌畏；O,O-二甲基-1,2-二溴-2,2-二氯代乙基磷酸酯；Bromex
分子式:	C₄H₇O₄PBr₂Cl2
分子量:	380.80
熔点:	26.5～27.5℃ 沸点：
密度:	1.96
蒸汽压:	110℃
溶解性:	不溶于水，易溶于芳烃，不溶于脂肪，能溶于丙酮、丙二
稳定性:	稳定
外观与性状:	室温下为白色结晶固体，高温下为无色粘稠油状液体，微有臭味
危险标记:	14(有毒品)
用途:	为残效期短的杀虫剂

2.对环境的影响:
一、健康危害
侵入途径：吸入、食入、经皮吸收。
健康危害：抑制胆碱酯酶，引起神经生理功能紊乱。中毒症状有头晕、无力、视物模糊、恶性循环心、呕吐、瞳孔缩小等。严重者出现肺水肿、昏迷等。
二、毒理学资料及环境行为
急性毒性：LD₅₀108mg/kg(大鼠经口)；300mg/kg(兔经皮)
致突变性：微生物致突变：鼠伤害沙门氏菌500nmol/皿；大肠杆菌20ul/皿。姊妹染色交换：人淋巴细胞 10nmol/L。
致癌性：IARC致癌性评论：动物阳性。
危险特性：遇明火、高热可燃。受热分解，放出有毒气体。
燃烧(分解)产物：氯化氢、溴化氢、氧化磷。

3.现场应急监测方法:　

4.实验室监测方法:
气相色谱法《固体废弃物试验分析评价手册》中国环境监测总站等译
气相色谱法(农作物)《农药残留量气相色谱法》国家商检局编

5.环境标准:

前苏联	车间空气中有害物质的最高容许浓度	0.5mg/m³
联合国规划署(1974)	保护水生生物淡水中农药的最大允许浓度	0.004μg/L
美国(1981年)	食物和饮料中最高残留限值	0.05～10.0mg/kg(特定动、植物粗制品)

6.应急处理处置方法:
一、泄漏应急处理
迅速撤离泄漏污染区，严格限制出入。切断火源，不要直接接触泄漏物。小量泄漏：用砂土或其它不燃材料吸附或吸收。大量泄漏：构筑围堤或挖坑收容；用泡沫覆盖，降低蒸气灾害。用泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。若是固体，用洁净的铲子收集于干燥、洁净、有盖的容器中。若大量泄漏，收集回收或运至废物处理场所处置。
二、防护措施
呼吸系统防护：生产操作或农业使用时，佩戴过滤式防毒面具(半面罩)。空气中浓度较高时，必须佩戴自给式呼吸器。
眼睛防护：戴化学安全防护眼镜。
身体防护：穿聚乙烯防毒服。
手防护：戴氯丁橡胶手套。
其它：皮肤防护也可采用塑料薄膜和涂皂面布相结合的方法。工作毕，淋浴更衣。注意个人清洁卫生。
三、急救措施
皮肤接触：立即脱去被污染的衣着，用肥皂水及流动清水彻底冲洗污染的皮肤、头发、指甲等。就医。
眼睛接触：提起眼睑，用流动清水或生理盐水冲洗。就医。
吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。
食入：饮足量温水，催吐，用清水或2%～5%碳酸氢钠溶液洗胃。就医。
灭火方法：消防人员须佩戴防毒面具、穿全身消防服。用干粉、砂土、泡沫与二氧化碳灭火器灭火。

二溴磷

二溴磷制备方法及用途

制备方法

合成制备方法

用途简介

用途

二溴磷物化性质

二溴磷安全信息

二溴磷毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

二溴磷 MSDS

二溴磷海关数据

中国海关编码：2919900090

二溴磷分子结构与计算化学数据

分子结构数据

计算化学数据

二溴磷表征图谱

推荐供应商

二溴磷

二溴磷 制备方法及用途

制备方法

合成制备方法

用途简介

用途

二溴磷 物化性质

二溴磷 安全信息

二溴磷 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

二溴磷 MSDS

二溴磷 海关数据

中国海关编码：2919900090

二溴磷 分子结构与计算化学数据

分子结构数据

计算化学数据

二溴磷 表征图谱

推荐供应商

二溴磷制备方法及用途

二溴磷物化性质

二溴磷安全信息

二溴磷毒理性

二溴磷海关数据

二溴磷分子结构与计算化学数据

二溴磷表征图谱