六氯苯,118-74-1，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

海关数据

结构与计算化学

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六氯苯

中文名称：: 六氯苯

中文别名：: 六氯苯;
六氯代苯;
全氯代苯;
灭黑穗药;
六氯苯13C6;
六氯苯(HCB);
气相色谱/质谱联用仪校准用;
过氯苯

英文名称：: Benzene,1,2,3,4,5,6-hexachloro-

英文别名：: Benzene, 1,2,3,4,5,6-hexachloro-;
hexachlorobenzene;
Hexachlorobenzene;
perchlorobenzene;
Hexachlorobenzene 13C6;
HCB;
Hexachlorobenzene solution

CAS No.：: 118-74-1

分子式：: C₆Cl₆

分子量：: 284.76

精确分子量：: 281.81312

PSA：: 0.00 A2

MDL：: MFCD00000540

EINECS：: 204-273-9

BRN：: 1912585

InChI：: InChI=1/C6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)93

危险品标志：: T:Toxic
N:Dangerous for the environment

风险术语：: R45; R48/25; R50/53;

安全术语：: S45; S53; S60;

分子结构式：

SDS：: 查看

六氯苯制备方法及用途

制备方法

1.三氯苯氯法将三氯苯加热至110℃,保温干燥1h,能氯气氯化,反应时放出热量,起始温度100-120℃,最终温度为260-270℃,氯化10-14h,当温度开始下降时即表示氯化反应已达终点,停止通氯,将熔融的物料放入盛水的结晶箱,搅拌下六氯苯结晶成粒。用冷水洗涤,即得六氯苯。 2.六六六无效体直接氯化法无效体经热风干燥至含水量在1%以下,加入熔融釜中,加热至150-170℃熔化,然后加入洗涤器和氯化塔。洗涤器温度保持在210-230℃,氯化塔通氯后,依照反应热慢慢升温,控制通氯速度,使反应温度每小时上升2-3℃。氯化塔的含氯尾气通入洗涤器吸收后送至副产盐酸系统。当氯化温度达260-270℃,并迅速放入盛水的结晶罐中骤冷结晶即得成品。

合成制备方法

1.三氯苯氯法将三氯苯加热至110℃，保温干燥1h，能氯气氯化，反应时放出热量，起始温度100-120℃，最终温度为260-270℃，氯化10-14h，当温度开始下降时即表示氯化反应已达终点，停止通氯，将熔融的物料放入盛水的结晶箱，搅拌下六氯苯结晶成粒。用冷水洗涤，即得六氯苯。

2.六六六无效体直接氯化法无效体经热风干燥至含水量在1%以下，加入熔融釜中，加热至150-170℃熔化，然后加入洗涤器和氯化塔。洗涤器温度保持在210-230℃，氯化塔通氯后，依照反应热慢慢升温，控制通氯速度，使反应温度每小时上升2-3℃。氯化塔的含氯尾气通入洗涤器吸收后送至副产盐酸系统。当氯化温度达260-270℃，并迅速放入盛水的结晶罐中骤冷结晶即得成品。

用途简介

1.用作拌种杀菌剂,可防治小麦腥黑穗病和杆黑穗病。用于生产花炮,作焰火色剂。 2.用作五氯酚及五氯酚钠的原料。 3.有机元素微量分析时用做氯的标准,也用于有机合成。 4.用于防治麦类黑穗病,种子和土壤消毒。

用途

1.用作拌种杀菌剂，可防治小麦腥黑穗病和杆黑穗病。用于生产花炮，作焰火色剂。

2.用作五氯酚及五氯酚钠的原料。

3.有机元素微量分析时用做氯的标准，也用于有机合成。

4.用于防治麦类黑穗病，种子和土壤消毒。^[27]

六氯苯毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA2975000

CHEMICAL NAME :: Benzene, hexachloro-

CAS REGISTRY NUMBER :: 118-74-1

BEILSTEIN REFERENCE NO. :: 1912585

LAST UPDATED :: 199712

DATA ITEMS CITED :: 68

MOLECULAR FORMULA :: C6-Cl6

MOLECULAR WEIGHT :: 284.76

WISWESSER LINE NOTATION :: GR BG CG DG EG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3600 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1600 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1800 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >6400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2022 mg/kg/55D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1596 mg/kg/28D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3326 mg/kg/15W-I

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg/6W-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1729 mg/kg/13W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Endocrine - adrenal cortex hyperplasia Blood - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg/5W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg/60D-C

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1512 mg/kg/18W-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 842 mg/kg/6W-C

TOXIC EFFECTS :: Immunological Including Allergic - decrease in humoral immune response

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 36400 mg/kg/1Y-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 3840 mg/kg/60D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 455 mg/kg/13W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in thyroid weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 4704 mg/kg/28W-C

TOXIC EFFECTS :: Endocrine - changes in thymus weight Endocrine - changes in thyroid weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 5 gm/kg/10D-I

TOXIC EFFECTS :: Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 2500 mg/kg/5D-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2738 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Blood - leukemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6972 mg/kg/83W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 1000 mg/kg/18W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - thyroid tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 3360 mg/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 3360 mg/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5475 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1050 mg/kg/30W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6300 mg/kg/90W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 556 mg/kg

SEX/DURATION :: female 96 day(s) pre-mating - 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 40 mg/kg

SEX/DURATION :: female 10-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6450 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 88 mg/kg

SEX/DURATION :: male 70 day(s) pre-mating female 70 day(s) pre-mating - 22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 812 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 212 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating - 17 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 7-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 mg/kg

SEX/DURATION :: female 6-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - biochemical and metabolic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 625 mg/kg

SEX/DURATION :: female 8-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 910 ug/kg

SEX/DURATION :: female 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 27562 ug/kg

SEX/DURATION :: female 66 day(s) pre-mating - 28 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 6 mg/L

REFERENCE :: BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 39,359,1986 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.002 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,155,1979 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,219,1987 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,219,1987 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 56,107,1975 TOXICOLOGY REVIEW JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 183,88,1963 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FRANCE;Carcinogen JAN 1993 OEL-RUSSIA:STEL 0.9 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1753 No. of Facilities: 10 (estimated) No. of Industries: 2 No. of Occupations: 12 No. of Employees: 1038 (estimated) No. of Female Employees: 26 (estimated)

毒理学数据：

1.急性毒性^[11]

LD50：3500mg/kg（大鼠经口）；4000mg/kg（小鼠经口）；2600mg/kg（兔经口）

2.刺激性 暂无资料

3.亚急性与慢性毒性^[12] 动物亚急性和慢性毒性反应有神经毒性症状，肝、肾重量增加，尿中粪卟啉排泄增加等。

4.致突变性^[13] DNA损伤：鼠伤寒沙门菌20μmol/L。微生物致突变：酿酒酵母菌100ppm。DNA加合物：大肠杆菌20μmol/L。哺乳动物体细胞突变：仓鼠肺6mg/L。

5.致畸性^[14] 大鼠孕后10~13d经口给予最低中毒剂量（TDLo）40mg/kg，致肌肉骨骼系统发育畸形。大鼠孕后1~22d经口给予最低中毒剂量（TDLo）6450mg/kg，致血液和淋巴系统（包括脾和骨髓）、免疫和网状内皮系统发育畸形。小鼠孕后7~16d经口给予最低中毒剂量（TDLo）1g/kg，颅面部（包括鼻、舌）、泌尿系统发育畸形。雌鼠交配前14d经口给予最低中毒剂量（TDLo）100mg/kg，致中枢神经系统发育畸形。

6.致癌性^[15] IARC致癌性评论：G2B，可疑人类致癌物。

7.其他^[16] 大鼠经口最低中毒剂量（TDLo）：40mg/kg（孕后10~13d用药），对胎鼠肌肉、骨骼系统有影响。小鼠经口最低中毒剂量（TDLo）：1g/kg，有胚胎毒性，对泌尿生殖系统有影响。

生态数据：

1.生态毒性^[17]

LC50：22mg/L（96h）（黑头呆鱼，静态）；12mg/L（96h）（蓝鳃太阳鱼，静态）

2.生物降解性^[18]

好氧生物降解（h）：23256~50136

厌氧生物降解（h）：93024~200544

3.非生物降解性^[19]

光解最大光吸收波长范围（nm）：291~301

空气中光氧化半衰期（h）：3753~37530

4.生物富集性^[20] BCF：11000~27000（鲤鱼，接触浓度0.5ppb，接触时间8周）；6000~30000（鲤鱼，接触浓度0.05ppb，接触时间8周）

六氯苯 MSDS

国标编号:	61876
ＣＡＳ:	118-74-1
中文名称:	六氯苯
英文名称:	Hexachlorobenzene；Hexachlorbenzd
别名:	灭黑穗药
分子式:	C₆Cl₆
分子量:	284.78
熔点:	226℃ 沸点：323～326
密度:	相对密度(水=1)2.44；
蒸汽压:	242℃
溶解性:	不溶于水，溶于乙醚、氯仿等多数有机溶剂
稳定性:	稳定
外观与性状:	纯品为无色细针状或小片状晶体，工业品为淡黄色或淡棕色晶体
危险标记:	14(有毒品)
用途:	用作防治麦类黑穗病，种子和土壤消毒

2.对环境的影响:
一、健康危害

侵入途径：吸入、食入。
健康危害：中毒时能影响肝脏、中枢神经系统和心血管系统。用本品拌种时引起眼刺激、烧灼感、口鼻发干、疲乏、头痛、恶心等。可致皮肤溃疡。接触者尿和粪中有大量紫质排出。
二、毒理学资料及环境行为

急性毒性：LD₅₀3500mg/kg(大鼠经口)；4000mg/kg(小鼠经口)
亚急性和慢性毒性：动物亚急性和慢性毒性反应有神经毒性症状，肝、肾重量增加，尿中粪卟啉排泄增加等。
致突变性：DNA损伤：鼠伤寒沙门氏菌20umol/L。微粒体致突变：制酒酵母菌100ppm。
生殖毒性：大鼠经口最低中毒剂量(TDL₀)：40mg/kg(孕后10～13天用药)，对胎鼠肌肉、骨骼系统有影响。小鼠经口最低中毒剂量(TDL₀)：1g/kg，有胚胎毒性，对泌尿生殖系统有影响。
致癌性：IARC致癌性评论：人为可疑性反应，动物为阳性反应。
危险特性：不易燃烧。受高热分解产生有毒腐蚀性烟气。
燃烧(分解)产物：一氧化碳、二氧化碳、氯化氢。

3.现场应急监测方法:

　

4.实验室监测方法:

气相色谱法《水和废水监测分析方法》(第三版)国家环保局编
气相色谱法《固体废弃物试验分析评价手册》中国环境监测总站等译

5.环境标准:

前苏联	车间空气中有害物质的最高容许浓度	0.9mg/m³
前苏联(1977)	居民区大气中有害物最大允许浓度	0.03mg/m³(最大值，昼夜均值)
中国(待颁布)	饮用水源中有害物质的最高容许浓度	0.05mg/L
中国(GHZB1-1999)	地表水环境质量标准(I、II、III类水域)	0.05mg/L

6.应急处理处置方法:

一、泄漏应急处理

隔离泄漏污染区，周围设警告标志，切断火源。应急处理人员戴好防毒面具，穿一般消防防护服。用洁净的铲子收集于干燥洁净有盖的容器中，用水泥、沥青或适当的热塑性材料固化处理再废弃。如大量泄漏，收集回收或无害处理后废弃。
废弃物处置方法：目前处置方法包括焚烧法、深井灌注法和填埋法。最有效的方法是焚烧法。
二、防护措施

呼吸系统防护：可能接触其粉尘时，应该佩戴防毒口罩。紧急事态抢救或撤离时，建议佩戴自给式呼吸器。
眼睛防护：必要时戴化学安全防护眼镜。
防护服：穿工作服。
手防护：戴防化学品手套。
其它：工作现场禁止吸烟、进食和饮水。工作后，彻底清洗。及时换洗工作服。注意个人清洁卫生。
三、急救措施

皮肤接触：脱去污染的衣着，用大量清水彻底冲洗。
眼睛接触：立即翻开上下眼睑，用流动清水或生理盐水冲洗。就医。
吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。就医。
食入：给饮足量温水，催吐。就医。

灭火方法：雾状水、泡沫、二氧化碳、干粉、砂土。

六氯苯

六氯苯制备方法及用途

制备方法

合成制备方法

用途简介

用途

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六氯苯毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

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MUTATION DATA

六氯苯 MSDS

3.现场应急监测方法:

4.实验室监测方法:

5.环境标准:

6.应急处理处置方法:

六氯苯海关数据

中国海关编码：2903920000

六氯苯分子结构与计算化学数据

分子结构数据

计算化学数据

六氯苯下游产品

六氯苯表征图谱

推荐供应商

六氯苯

六氯苯 制备方法及用途

制备方法

合成制备方法

用途简介

用途

六氯苯 物化性质

六氯苯 安全信息

六氯苯 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

六氯苯 MSDS

3.现场应急监测方法:

4.实验室监测方法:

5.环境标准:

6.应急处理处置方法:

六氯苯 海关数据

中国海关编码：2903920000

六氯苯 分子结构与计算化学数据

分子结构数据

计算化学数据

六氯苯 下游产品

六氯苯 表征图谱

推荐供应商

六氯苯制备方法及用途

六氯苯物化性质

六氯苯安全信息

六氯苯毒理性

六氯苯海关数据

六氯苯分子结构与计算化学数据

六氯苯下游产品

六氯苯表征图谱