2-乙氧基乙醇,110-80-5，生产厂家，价格-洛克化工网移动版

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2-乙氧基乙醇

中文名称：: 2-乙氧基乙醇

中文别名：: 乙二醇乙醚;
赛罗沙夫;
乙二醇单乙醚;
乙二醇一乙醚;
2-羟基乙醚;
乙基溶纤剂;
2-乙氧基乙醇

英文名称：: 2-Ethoxyethanol

英文别名：: 2-ethoxyethanol;
celosolv;
dowanol8;
Emkanol;
Ethylene Glycol Monoethyl Ether;
2EE;
ethylene glycol monoethyl ether;
2-ethoxy-ethanol;
Ethyl Cellosolve;
2-ethoxy-1-ethanol;
Ethyl Glycol;
OXITOL;
egmee;
dowanolee;
OXYTOL;
Ethyl glycol,Ethylene glycol monoethyl ether;
monoethylene glycol ethyl ether;
2-Ethoxyethanol;
EGEE;
2-hydroxyethyl ethyl ether;
2-ethoxyethyl alcohol

CAS No.：: 110-80-5

分子式：: C₄H₁₀O₂

分子量：: 90.12

精确分子量：: 90.06810

PSA：: 29.46000

MDL：: MFCD00002869

EINECS：: 203-804-1

BRN：: 1098271

InChI：: InChI=1/C4H10O.C2H6O2/c1-3-5-4-2;3-1-2-4/h3-4H2,1-2H3;3-4H,1-2H23

危险品标志：: T

风险术语：: R10; R20/21/22; R60

安全术语：: S45; S53

分子结构式：

SDS：: 查看

2-乙氧基乙醇制备方法及用途

制备方法

由环氧乙烷与乙醇反应而得。在25-30℃,将环氧乙烷缓加入无水乙醇中,待温度升至70℃,反应完后放置过夜。回收乙醇,用10%氢氧化钠溶液中和至pH=8,分馏得粗品。精馏,收集133.5-135.5℃馏分得成品。每吨产品消耗环氧乙烷863kg,无水乙醇1020kg。

合成制备方法

1.由环氧乙烷与乙醇反应而得。在25-30℃，将环氧乙烷缓加入无水乙醇中，待温度升至70℃，反应完后放置过夜。回收乙醇，用10%氢氧化钠溶液中和至pH=8，分馏得粗品。精馏，收集133.5-135.5℃馏分得成品。每吨产品消耗环氧乙烷863kg，无水乙醇1020kg。

精制方法：易含的杂质有水分、二甘醇一乙醚(乙基卡必醇)、乙二醇和微量的酸、醛等。精制时加入氯化钙或无水硫酸钠干燥，然后分馏。若有过氧化物存在，可用二氯化锡回流，或将其通过活性氧化铝柱除去。

用途简介

用作溶剂,以及皮革着色剂、乳化剂、稳定剂、涂料稀释剂、脱漆剂、有机中间体等。

用途

1.本品常用作硝化纤维素、醋酸纤维、合成树脂、油漆的溶剂；皮革工业用于着色剂、乳液稳定剂、油墨溶剂；维生素B12精制溶剂；涂料工业用于配制油漆稀释剂、脱漆剂及制造喷漆的原料；纺织工业用于制造纤维的染色剂；有机化工中用于制造醋酸酯、乳液稳定剂等。本品除上述应用外，还可用于木材着色用染料的溶剂，石油皂、石油磺酸的溶剂，有机合成工业用于非油漆着色剂和用于制备有机化合物的中间体，以及分析化学试剂等。多乙二醇单乙醚主要用作涂料、油墨、染料、树脂、硝化纤维素的高沸点溶剂，此外，该产品还广泛用于高级汽车刹车液的配方中，还可用于制备酯类衍生物中间体等。

2.通用溶剂和电子工业用溶剂。用于皮革着色剂、乳化液、稳定剂等。

3.一种性能优良的溶剂。用作硝酸纤维素、树脂、油漆、油溶性染料及搪瓷的溶剂。也用作农药分散剂、纤维润湿剂、医药萃取剂、织物及塑料去污剂、金属清洁剂等。

4.用作溶剂，以及皮革着色剂、乳化剂、稳定剂、涂料稀释剂、脱漆剂等。^[28]

2-乙氧基乙醇物化性质

外观与性状：: 透明无色,几乎无气味的液体
密度：: 0.93 g/mL at 25 °C(lit.)
熔点：: -100 °C
沸点：: 135 °C(lit.)
闪点：: 107.6 °F
水溶解性：: miscible
折射率：: n20/D 1.407(lit.)
蒸汽压：: 0.0227mmHg at 25°C
蒸汽密度：: 3.1 (vs air)
存储条件/存储方法：: 库房通风低温干燥,与氧化剂分开储运
稳定性相关：: 1.稳定性^[23] 稳定
2.禁配物^[24] 强氧化剂、酸类、碱类
3.避免接触的条件^[25] 空气、光照
4.聚合危害^[26] 不聚合
其它信息：: 1.性状：无色油状液体，有醚味。^[1]
2.熔点（℃）：-70^[2]
3.沸点（℃）：135.1^[3]
4.相对密度（水=1）：0.94（15℃）^[4]
5.相对蒸气密度（空气=1）：3.10^[5]
6.饱和蒸气压（kPa）：0.51（20℃）^[6]
7.临界压力（MPa）：4.24^[7]
8.辛醇/水分配系数：-0.32^[8]
9.闪点（℃）：43（CC）；49（OC）^[9]
10.引燃温度（℃）：235^[10]
11.爆炸上限（%）：15.6^[11]
12.爆炸下限（%）：1.7^[12]
13.溶解性：与水混溶，可混溶于乙醇、乙醚、丙酮等多数有机溶剂。^[13]
14.黏度（mPa·s,20ºC）：2.05
15.黏度（mPa·s,25ºC）：1.85
16.蒸发热（KJ/mol,b.p.）：40.56
17.蒸发热（KJ/mol,25ºC）：47.28
18.比热容（KJ/(kg·K),25ºC,定压）：2.32
19.电导率（S/m,20ºC）：9.3×10^-8
20.蒸气压（kPa,25ºC）：0.7
21.体膨胀系数（K^-1）：0.00097
22.溶度参数(J·cm^-3)^0.5：21.541
23.van der Waals面积（cm²·mol^-1）：8.230×10⁹
24.van der Waals体积（cm³·mol^-1）：56.100
25.液相标准热熔(J·mol^-1·K^-1) ：211.1

2-乙氧基乙醇安全信息

包装等级：: III
风险类别：: 3
海关代码：: 2909499000
WGK_Germany：: 1
德国有关水污染物质的分类清单
危险类别码：: R10;R20/21/22;R60;R61
安全说明：: S53-S45
RTECS号：: KK8050000
安全标志：: S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S53:避免暴露——使用前先阅读专门的说明。
危险标志：: T:Toxic

2-乙氧基乙醇毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KK8050000

CHEMICAL NAME :: Ethanol, 2-ethoxy-

CAS REGISTRY NUMBER :: 110-80-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 96

MOLECULAR FORMULA :: C4-H10-O2

MOLECULAR WEIGHT :: 90.14

WISWESSER LINE NOTATION :: Q2O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Human

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - guinea pig

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2125 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - withdrawal Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2000 ppm/7H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2451 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1820 ppm/7H

TOXIC EFFECTS :: Behavioral - analgesia Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1707 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in spleen

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3900 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5799 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3000 ppm/24H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3070 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 26452 mg/kg/6W-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 gm/kg/2W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18655 mg/kg/13W-C

TOXIC EFFECTS :: Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4000 ppm/4H/2W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1370 mg/m3/7H/5W-I

TOXIC EFFECTS :: Blood - changes in spleen

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 gm/kg/2W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 660 gm/kg/13W-C

TOXIC EFFECTS :: Endocrine - effect on menstrual cycle Endocrine - other changes Blood - changes in spleen

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 840 ppm/7H/12W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Blood - microcytosis with or without anemia Blood - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 400 ppm/6H/13W-I

TOXIC EFFECTS :: Blood - normocytic anemia Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 7820 mg/kg

SEX/DURATION :: female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 mg/kg

SEX/DURATION :: female 10-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1800 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4500 mg/kg

SEX/DURATION :: male 6 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 10 ppm/6H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 200 ppm/7H

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 600 ppm/7H

SEX/DURATION :: female 7-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 100 ppm/7H

SEX/DURATION :: female 14-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 50 gm/kg

SEX/DURATION :: female 7-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 50 gm/kg

SEX/DURATION :: female 7-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 50 gm/kg

SEX/DURATION :: female 7-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1955 mg/kg

SEX/DURATION :: female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 25 gm/kg

SEX/DURATION :: male 25 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 252 gm/kg

SEX/DURATION :: female 18 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5600 mg/kg

SEX/DURATION :: female 8-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 12600 mg/kg

SEX/DURATION :: female 8-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 400 ppm/6H

SEX/DURATION :: male 65 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 160 ppm/7H

SEX/DURATION :: female 1-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 160 ppm/7H

SEX/DURATION :: female 1-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 160 ppm/7H

SEX/DURATION :: female 1-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 617 ppm/7H

SEX/DURATION :: female 1-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** ACGIH TLV-TWA 18 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 100 ppm (370 mg/m3) (skin) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,18,1973 OSHA PEL (Gen Indu):8H TWA 200 ppm (740 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 200 ppm (740 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 200 ppm (740 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 200 ppm (740 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (18 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (18.5 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 50 ppm (185 mg/m3);STEL 100 ppm (370 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 20 ppm (75 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 70 mg/m3;STEL 140 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 5 ppm (18 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 200 ppm (740 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 200 mg/m3 JAN 1993 OEL-RUSSIA:TWA 5 ppm;STEL 5 mg/m3 JAN 1993 OEL-SWEDEN:TWA 5 ppm (19 mg/m3);STEL 10 ppm (40 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (19 mg/m3);STEL 10 ppm (38 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 200 ppm (740 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (37 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ETHYLENEGLYCOL MONOETHYL ETHER-air:10H TWA 0.5 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 31350 No. of Facilities: 43849 (estimated) No. of Industries: 253 No. of Occupations: 154 No. of Employees: 406097 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 31350 No. of Facilities: 16505 (estimated) No. of Industries: 153 No. of Occupations: 106 No. of Employees: 264436 (estimated) No. of Female Employees: 72493 (estimated)

毒理学数据：

1.急性毒性^[14]

LD50：2125mg/kg（大鼠经口）；3900mg/kg（大鼠经皮）；3300mg/kg（兔经皮）

LC50：2000ppm（大鼠吸入，7h）

2.刺激性^[15]

家兔经皮：500mg，轻度刺激（开放性刺激试验）。

家兔经眼：50mg，中度刺激。

3.亚急性与慢性毒性^[16] 大鼠暴露于1.49g/m³，每天7h，每周5d，5周，对血液细胞成分有轻微影响。兔经口，每天0.1ml/kg，第7d出现暂时性蛋白尿、血尿；1ml/kg，第8d因肾损害而死亡。

4.致突变性^[17] 精子形态学：大鼠经口23400mg/kg，5周（间歇）。姐妹染色单体交换：仓鼠卵巢3170mg/L。

5.致畸性^[18] 大鼠孕后10~12d经口给予最低中毒剂量（TDLo）600mg/kg，致肌肉骨骼系统、心血管系统发育畸形。大鼠孕后7~16d皮肤染毒最低中毒剂量（TDLo）50g/kg，致中枢神经系统、泌尿生殖系统发育畸形。

6.其他^[19] 大鼠经口最低中毒剂量（TDLo）：600mg/kg（孕10~12d），致胚胎毒性（如胚胎发育迟缓），致骨骼肌肉发育异常，心血管（循环）系统发育异常。小鼠经口最低中毒剂量（TDLo）：25g/kg（25d，雄性），影响睾丸、附睾和输精管。

生态数据：

1.生态毒性^[20]

LC50：＞10000mg/L（96h）（蓝鳃太阳鱼）；＞5000mg/L（24h）（水蚤）

2.生物降解性^[21]

好氧生物降解性（h）：168~672

厌氧生物降解性（h）：672~2688

3.非生物降解性^[22]

空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期为1d（理论）。

2-乙氧基乙醇 MSDS

第一部分：化学品名称

2-乙氧基乙醇海关数据

中国海关编码：2909499000

概述：: 2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%
申报要素：: 品名, 成分含量, 用途
摘要/Summary：: 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

2-乙氧基乙醇分子结构与计算化学数据

分子结构数据

1、摩尔折射率：23.86

2、摩尔体积（cm³/mol）：98.4

3、等张比容（90.2K）：227.6

4、表面张力（dyne/cm）：28.6

5、极化率（10^-24cm³）：9.45

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:1

3.氢键受体数量:2

4.可旋转化学键数量:3

5.互变异构体数量:无

6.拓扑分子极性表面积29.5

7.重原子数量:6

8.表面电荷:0

9.复杂度:21.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

2-乙氧基乙醇上游产品

环氧乙烷乙醇二氧化碳异丙醇

2-乙氧基乙醇下游产品

2-乙氧基月桂酸氰乙酸乙氧基乙酯 4-羟基-2H-1,2-苯并噻嗪-3-羧酸甲酯1,1-二氧化物 2-甲基-1,3-二噁茂烷

2-乙氧基乙醇表征图谱

2-乙氧基乙醇核磁图(¹HNMR)
2-乙氧基乙醇Raman光谱
2-乙氧基乙醇核磁图(¹³CNMR)
2-乙氧基乙醇质谱(MS)
2-乙氧基乙醇红外图谱(IR2)
2-乙氧基乙醇红外图谱(IR1)

2-乙氧基乙醇

2-乙氧基乙醇 制备方法及用途

制备方法

合成制备方法

用途简介

用途

2-乙氧基乙醇 物化性质

2-乙氧基乙醇 安全信息

2-乙氧基乙醇 毒理性