美坦新
- 中文名称：
- 美坦新
- 中文别名：
- 美坦新;
美登素
- 英文名称：
- Maytansine
- 英文别名：
- maytansine;
maitansine;
(3E,5E,7R,84S)-12c-(N-acetyl-N-methyl-L-alanyloxy)-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione;
Maytansine
- CAS No.：
- 35846-53-8
- 分 子 式：
-
C34H46ClN3O10
- 分 子 量：
- 678.27
- 精确分子量：
- 691.28700
- PSA：
- 156.47000
- EINECS：
- 252-754-7
- InChI：
- The Key: WKPWGQKGSOKKOO-SIBNOYASSA-N3
- 安全术语：
- A deadly poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. Human systemic effects by intravenous route: hallucinations, distorted perceptions, change in motor activity, and nausea or vomiting. An experimental teratogen. Mutation data reported. Used as an antineoplastic agent. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
- 分子结构式：
-
- SDS：
- 查看
美坦新 物化性质
- 密度：
- 1.32g/cm3
- 熔点：
- 183.5-184℃
- 沸点：
- 895.1ºC at 760mmHg
- 闪点：
- 495.1ºC
- 折射率：
- 1.59
美坦新 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OQ2290000
- CHEMICAL NAME :
- Maytansine
- CAS REGISTRY NUMBER :
- 35846-53-8
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C34-H46-Cl-N3-O10
- MOLECULAR WEIGHT :
- 692.28
- WISWESSER LINE NOTATION :
- T D3 K6-19-6 A K- EO IVN WNVO QU SUTJ C1 GOVY1&N1&V1
J1 LG MO1 Q1 UO1 VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 190 ug/kg/5D
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions
Behavioral - changes in motor activity (specific assay)
Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 480 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 245 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1530 ug/kg
- TOXIC EFFECTS :
- Blood - leukopenia
Blood - thrombocytopenia
Skin and Appendages - hair
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1305 ug/kg/7W-I
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - body temperature increase
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 700 ug/kg/5D-I
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity
Blood - pigmented or nucleated red blood cells
Blood - leukopenia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 200 ug/kg
- SEX/DURATION :
- female 7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 200 ug/kg
- SEX/DURATION :
- female 7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 200 ug/kg
- SEX/DURATION :
- female 7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 250 ug/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - cytological changes (including
somatic cell genetic material)
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - mouse Ascites tumor
- DOSE/DURATION :
- 100 ug/kg
- REFERENCE :
- JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
60,649,1978
美坦新 上游产品
(14S,16S,2R,3E,5E,12S,13E,15S)-84-chloro-12-hydroxy-14,85,2-trimethoxy-6,9,13,15-tetramethyl-9-aza-1(4,6)-oxazinana-8(1,3)-benzenacyclopentadecaphane-3,5,13-triene-12,10-dione
(5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-5,12-dimethoxy-2,6,8,16-tetramethyl-3-oxospiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-9-yl carbamate
推荐供应商
上海源叶生物科技有限公司
35846-53-8
- 联系人：Yuki
- 电 话：021-61845781
- 手 机：13585604150
- Cas号：35846-53-8
- 包装：5mg,10mg
- 纯度：98%
- 价格：1,600.0元 - 2,400.0元
湖北恩星生物科技有限公司
美坦新
- 联系人：邵经理
- 电 话：16621771607
- 手 机：16621771607
- Cas号：35846-53-8
- 包装：100kg,200kg,300kg,400kg,500kg
- 纯度：
- 价格：64.0元 - 100.0元
成都乐美天医药科技有限公司
美坦新
- 联系人：梁
- 电 话：028-85003950
- 手 机：17313084125
- Cas号：35846-53-8
- 包装：1mg
- 纯度：HPLC≥98%
- 价格：洽谈
