硫酸羟氯喹
- 中文名称:
- 硫酸羟氯喹
- 中文别名:
- 硫酸羟氯喹;
羟基氯喹;
2-[[4-[(7-氯喹啉-4-基)氨基]戊基](乙基)氨基]乙醇
- 英文名称:
- Ethanol,2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-
- 英文别名:
- hydroxychloroquine;
Polirreumin;
Oxychloroquine;
Oxichlorochinum;
Plaquenil;
2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;
Hydroxychlorochin;
Oxychlorochin;
Hidroxicloroquina;
Oxichloroquine;
Quensyl
- CAS No.:
- 118-42-3
- 分 子 式:
-
C18H26ClN3O
- 分 子 量:
- 335.87
- 精确分子量:
- 335.17600
- PSA:
- 48.39000
- MDL:
- MFCD00078203
- EINECS:
- 204-249-8
- InChI:
- The Key: XXSMGPRMXLTPCZ-UHFFFAOYSA-N3
- 分子结构式:
-
- SDS:
- 查看
硫酸羟氯喹 制备方法及用途
制备方法
抗疟药,用于红斑狼疮和风湿性关节炎的治疗
用途简介
硫酸羟氯喹 物化性质
- 密度:
- 1.176 g/cm3
- 沸点:
- 516.7ºC at 760 mmHg
- 闪点:
- 266.3ºC
- 蒸汽压:
- 1.68E-11mmHg at 25°C
硫酸羟氯喹 安全信息
- 海关代码:
- 3004390090
- 安全标志:
- S26:万一接触眼睛,立即使用大量清水冲洗并送医诊治。
硫酸羟氯喹 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KK3325000
- CHEMICAL NAME :
- Ethanol,
2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)-
- CAS REGISTRY NUMBER :
- 118-42-3
- BEILSTEIN REFERENCE NO. :
- 0253894
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C18-H26-Cl-N3-O
- MOLECULAR WEIGHT :
- 335.92
- WISWESSER LINE NOTATION :
- T66 BNJ EMY1&3N2&2Q IG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - increased intracranial pressure
Behavioral - convulsions or effect on seizure threshold
Cardiac - other changes
- REFERENCE :
- JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312,
Niles, IL 60648) V.1- 1977- Volume(issue)/page/year: 14,186,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 88 mg/kg/11D-I
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, allergic (after systemic exposure)
- REFERENCE :
- JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63141) 1979-
Volume(issue)/page/year: 12,857,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 112 mg/kg/2W-I
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, irritative (after systemic exposure)
- REFERENCE :
- JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont.,
Canada) V.1- 1974- Volume(issue)/page/year: 12,391,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 429 mg/kg/25D
- TOXIC EFFECTS :
- Blood - agranulocytosis
Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 1,1275,1965
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 154 mg/kg/18D-I
- TOXIC EFFECTS :
- Behavioral - toxic psychosis
- REFERENCE :
- JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63141) 1979-
Volume(issue)/page/year: 12,863,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1240 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 12,184,1969
硫酸羟氯喹 分子结构与计算化学数据
分子结构数据
1、 摩尔折射率:98.96
2、 摩尔体积(cm3/mol):285.3
3、 等张比容(90.2K):758.0
4、 表面张力(dyne/cm):49.8
5、 极化率(10-24cm3):39.23
计算化学数据
1.疏水参数计算参考值(XlogP):无
2.氢键供体数量:2
3.氢键受体数量:4
4.可旋转化学键数量:9
5.互变异构体数量:3
6.拓扑分子极性表面积48.4
7.重原子数量:23
8.表面电荷:0
9.复杂度:331
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:1
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
推荐供应商
湖北万得化工有限公司
羟氯喹
- 联系人:王念
- 电 话:027-59210159
- 手 机:15172311821
- Cas号:118-42-3
- 包装:1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶,200kg镀锌铁桶/塑料桶,1t吨袋
- 纯度:99%
- 价格:1.0元 - 1,000.0元